The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Habitual dietary fibre intake influences gut microbiota response to an inulin-type fructan prebiotic: a randomised, double-blind, placebo-controlled, cross-over, human intervention study
Open accessAbstract
Dysbiotic gut microbiota have been implicated in human disease. Diet-based therapeutic strategies have been used to manipulate the gut microbiota towards a more favourable profile. However, it has been demonstrated that large inter-individual variability exists in gut microbiota response to a dietary intervention. The primary objective of this study was to investigate whether habitually low dietary fibre (LDF) v. high dietary fibre (HDF) intakes influence gut microbiota response to an inulin-type fructan prebiotic. In this randomised, double-blind, placebo-controlled, cross-over study, thirty-four healthy participants were classified as LDF or HDF consumers. Gut microbiota composition (16S rRNA bacterial gene sequencing) and SCFA concentrations were assessed following 3 weeks of daily prebiotic supplementation (Orafti® Synergy 1; 16 g/d) or placebo (Glucidex® 29 Premium; 16 g/d), as well as after 3 weeks of the alternative intervention, following a 3-week washout period. In the LDF group, the prebiotic intervention led to an increase in Bifidobacterium (P=0·001). In the HDF group, the prebiotic intervention led to an increase in Bifidobacterium (P<0·001) and Faecalibacterium (P=0·010) and decreases in Coprococcus (P=0·010), Dorea (P=0·043) and Ruminococcus (Lachnospiraceae family) (P=0·032). This study demonstrates that those with HDF intakes have a greater gut microbiota response and are therefore more likely to benefit from an inulin-type fructan prebiotic than those with LDF intakes. Future studies aiming to modulate the gut microbiota and improve host health, using an inulin-type fructan prebiotic, should take habitual dietary fibre intake into account.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In a prebiotic supplementation study, participants with high fiber intake at baseline showed a greater microbial response in response to an inulin-type fructan prebiotic than those with low habitual fiber intake (513).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [513]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887
Search and clustering orders of magnitude faster than BLAST
Edgar, R. C. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq461 · Cited by 21,098
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 20,145
Greengenes, a Chimera-Checked 16S rRNA Gene Database and Workbench Compatible with ARB
DeSantis, T. Z., Hugenholtz, P., Larsen, N., Rojas, M., Brodie, E. L., Keller, K., Huber, T., Dalevi, D., Hu, P., & Andersen, G. L. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.03006-05 · Cited by 10,891
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513
Gibson, G. R., Hutkins, R., Sanders, M. E., Prescott, S. L., Reimer, R. A., Salminen, S. J., Scott, K., Stanton, C., Swanson, K. S., Cani, P. D., et al. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.75 · Cited by 5,634
Dethlefsen, L., Huse, S., Sogin, M. L., & Relman, D. A. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060280 · Cited by 2,361
Flint, A., Raben, A., Blundell, J., & Astrup, A. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801083 · Cited by 2,238
Research works printed but not linked: 3
- 2011, A Focus on Nutrition: Key Findings of the 2008/09 New Zealand Adult Nutrition Survey
- 2006, Nutrient Reference Values for Australia and New Zealand- Executive Summary
- 2015, Eating and Activity Guidelines for New Zealand Adults
Cited by
Sorted by citations
Items 201–268 of 268
Mozzarella cheese as a vehicle for dietary fiber: Technological challenges and consumer acceptance
Antonino, C., Natrella, G., Angelis, D. D., Caliandro, P., & Faccia, M. (2026) · International Dairy Journal · doi:10.1016/j.idairyj.2026.106605 · Cited by 3
Thriene, K., Stanislas, V., Amend, L., Strowig, T., & Michels, K. B. (2022) · Foods · doi:10.3390/foods11223673 · Cited by 3
Mingat, S., Ehara, T., Nakamura, H., & Miyaji, K. (2024) · Nutrients · doi:10.3390/nu16193347 · Cited by 3
Peng, L. V., Cooper, J., Costa, P. D. M., & Chong, P.-W. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.790045 · Cited by 4
Precise Nutrition and Functional Foods
Ivanović, N., Hippe, B., Lilja, S., & Haslberger, A. G. (2022) · Springer eBooks · doi:10.1007/978-3-031-10153-3_10 · Cited by 4
Koehler, F. C., Späth, M. R., Meyer, A. M., & Müller, R. (2024) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000001159 · Cited by 4
Therapeutic Role of Inulin in Disease Management
Guglani, A., Shukla, S., & Tripathi, R. S. (2025) · Springer eBooks · doi:10.1007/978-981-97-9056-2_14 · Cited by 4
Effects of the use of prebiotics in the treatment of obesity
Santos, G. G. C., Filho, J. C. C. N., & Nunes, M. P. O. (2022) · Advances in Obesity Weight Management & Control · doi:10.15406/aowmc.2022.12.00361 · Cited by 3
Rodriguez, C. I., Keshavarzian, A., Hamaker, B. R., Liu, F., Lunken, G., Rasmussen, H. E., Zhou, H., Tap, J., Swanson, K. S., Ukhanova, M., et al. (2023) · Scientific Data · doi:10.1038/s41597-023-02254-4 · Cited by 3
Birkeland, E., Bamigbetan, W., Molven, K. D., Thorsby, P., Gulseth, H., Aas, A.-M., & Dahl, C. (2025) · Archives of Osteoporosis · doi:10.1007/s11657-025-01556-x · Cited by 2
Sadegh, H. R., & Choi, J. P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178622 · Cited by 2
From Fork to Feelings: How Foods Shape Mental Health via the Microbiota–Gut–Brain Axis
Ferri, A., Paes, L. T., Schneider, E., Clarke, G. A., & Cryan, J. F. (2026) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-053124-110137 · Cited by 3
The Gut Microbiota–Mast Cell Axis in Intestinal Homeostasis and Food Allergy Pathogenesis
Carnevale, A., Marangio, C., Putro, E., Molfetta, R., & Paolini, R. (2026) · Biomolecules · doi:10.3390/biom16020254 · Cited by 2
Competition and compromise between exogenous probiotics and native microbiota
Han, Z., Sun, Z., Zhao, Q., Du, L., Zhen, D., Liu, X., Jiang, S., Liu, Y., & Zhang, J. (2026) · Cell Systems · doi:10.1016/j.cels.2025.101516 · Cited by 2
Dellschaft, N. S., Alhasani, A. T., Reid, J. E. S. J., Hoad, C. L., Gates, E., Whymark, M., Yakubov, G. E., Marciani, L., Warren, F. J., Modasia, A. A., et al. (2026) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.70964 · Cited by 2
Carboni, A. D., Salinas, M. V., & Puppo, M. C. (2022) · Springer eBooks · doi:10.1007/978-3-030-81404-5_32-1 · Cited by 2
Carboni, A. D., Salinas, M. V., & Puppo, M. C. (2023) · Springer eBooks · doi:10.1007/978-3-031-28109-9_32 · Cited by 2
Armah, A. A., Jackson, C., Kolba, N., Gracey, P. R., Shukla, V., Padilla‐Zakour, O. I., Warkentin, T. D., & Tako, E. (2024) · Nutrients · doi:10.3390/nu16121856 · Cited by 2
Dietary Fiber: Composition and Health Effects by Microbiota
Watanabe, S. (2024) · Food science and nutrition · doi:10.5772/intechopen.115113 · Cited by 2
Chen, Y., Guo, Q., Sun, Y., Ni, Y., Ma, T., Xie, T., Li, C., Li, H., & Xing, Z. (2024) · LWT · doi:10.1016/j.lwt.2024.116978 · Cited by 2
Pitti, J. Á., de Blas, A., & Lurbe, E. (2020) · Nutrients · doi:10.3390/nu12113508 · Cited by 4
Li, R., Okoro, P. C., Zillikens, M., Vasan, R. S., Sahni, S., Rivadeneira, F., Kiel, D. P., & Medina‐Gómez, C. (2026) · Bone · doi:10.1016/j.bone.2026.118051 · Cited by 1
Wang, X., Guo, S., Xiong, L., Wu, X., Bao, P., Kang, Y., Cao, M., Ding, Z., Hu, L., Liang, C., et al. (2025) · Foods · doi:10.3390/foods14183173 · Cited by 1
Human Gut Microbiome in Relation to Food, Nutrition, Health and Disease
Menkovska, M., & Raza, S. (2025) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2025.1612036 · Cited by 1
Predicting Fiber Specificity on Gut Microbiome Modulation
Raghunath, R., Alvarez, M. A., Bhattarai, S., Pujari, A., Castillo, C. S., Arıoğlu-Tuncil, S., Wang, Y., Tunçil, Y. E., & Lindemann, S. R. (2026) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-053124-092050 · Cited by 1
Wang, W., Tao, Y., & Zhu, M. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1769785 · Cited by 1
The Role of Different Dietary Fibers in Modulating Human Gut Microbiota
Das, S., Fletcher, C., & Wu, Y. (2026) · Nutraceuticals · doi:10.3390/nutraceuticals6010018 · Cited by 5
Matcha Tea Quality and Functional Effects on Gut Microbiome: A Comprehensive Systematic Review
Gerasopoulos, A., Gerasopoulos, G., Giota, E., & Lazari, D. M. (2026) · Food Reviews International · doi:10.1080/87559129.2026.2653654 · Cited by 1
Osawa, R., Inoue, J., Fukuda, I., Shirai, Y., & Kodama, Y. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1907988 · Cited by 1
Healthy gut microbiome in the prevention of colorectal cancer
Rumman, M., Nagasaka, M., Al-Share, B. A., Azmi, A. S., & Uddin, M. H. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822238-6.00005-4 · Cited by 1
A comparison of the effects of sheep's milk and cow's milk on recovery from eccentric exercise
Ravenwood, B., Coad, J., & Barnes, M. J. (2024) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2023.1335434 · Cited by 4
Self-citationVigl, S. (2024) · Heilpflanzen · doi:10.1055/a-2351-0878 · Cited by 1
Formisano, A., Iacomino, G., Russo, M. D., Russo, P., Siani, A., & Lauria, F. (2025) · The microbiomes of humans, animals, plants, and the environment · doi:10.1007/978-3-031-93902-0_4 · Cited by 1
Inulin Type Fructan: A Versatile Functional Material for Food and Healthcare
Hussain, M. A., Haseeb, M. T., Muhammad, G., & Tahir, M. N. (2019) · Polymers and polymeric composites · doi:10.1007/978-3-319-92066-5_20-1 · Cited by 1
Impact of Precision Nutrition on Microbiota and Obesity
Merra, G., Gualtieri, P., LORENZO, A. D., Capacci, A., Frank, G., Dri, M., Renzo, L. D., & Marchetti, M. (2023) · Current Nutrition & Food Science · doi:10.2174/1573401319666230724112531 · Cited by 1
Li, X., Wang, L., Ma, S., Lin, S., Wang, C., & Hai-ya, W. (2021) · Research Square · doi:10.21203/rs.3.rs-142746/v1 · Cited by 1
Designer fibre meals sway human gut microbes
Leshem, A., & Elinav, E. (2021) · Nature · doi:10.1038/d41586-021-01601-y
The role of diet and physical activity in influencing the microbiota/microbiome
Murphy, E. A., & Velázquez, K. T. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-822130-3.00017-x
Microbiota in relation to cancer
Anisman, H., & Kusnecov, A. W. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91904-3.00007-0
Healey, G. R., Golding, L., Schick, A., Majdoubi, A., Lavoie, P. M., & Vallance, B. A. (2022) · medRxiv · doi:10.1101/2022.08.24.22279143
Self-citationForty‐fifth ASPEN Presidential Address: Medical nutrition therapy, is it time to get personal?
Cresci, G. (2023) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.2471
Chi, M. (2023) · International Conference on Modern Medicine and Global Health (ICMMGH) · doi:10.1117/12.2692594
Penarete-Acosta, D., Mittal, M., Chakraborty, S., Han, A., & Jayaraman, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.23.619945
Murdock, D. K. (2024) · Insights in Biology and Medicine · doi:10.29328/journal.ibm.1001028
Inulin and Gastrointestinal Disorders
Kadiri, S. K., Tiwari, P. K., Khobragade, D. S., & Sathavalli, D. (2025) · Springer eBooks · doi:10.1007/978-981-97-9056-2_11
Wang, X., Shu, Z., Wang, L., & Xu, X. (2025) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2025.04.003
Antunes, M., Jongen, L., Mateen, A., Sobral, J., van Uden, S., Vargas, N. S., & Pacheco, D. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.29.656766
Mollova, D., Baev, V., & Iliev, I. N. (2025) · Microorganisms · doi:10.3390/microorganisms13102352
Diet and nutritional management of gastrointestinal disorders
Singh, A., Srivastava, S., Singh, D., Mittal, N., & Nathani, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-36372-6.00004-5
Armet, A. M., Li, F., Deehan, E. C., Nikolaeva, D. D., Delannoy-Bruno, O., Siegwald, L., Berger, B. W., Minehira, K., Rodionov, D. A., Arzamasov, A. A., et al. (2025) · medRxiv · doi:10.1101/2025.11.20.25340625 · Cited by 2
Kırmızıbekmez, A. M., Önder, A., Ozdemir, M. Y., Gurerk, G., Aydın, S., Eryiğit, Ö. Y., Güloğlu, M. O., & Kara, İ. (2025) · Scientific Reports · doi:10.1038/s41598-025-29256-z · Cited by 1
Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials
Koehler, F. C., Rojas‐Morales, P., & Müller, R. (2026) · Experimental Physiology · doi:10.1113/ep092817 · Cited by 1
Bressuire, C., Thirion, F., Chiaravano, L., Ngom, S. I., Marion, R., Gilles, M., Quinquis, B., Mathieu, E., Berland, M., Blottière, H. M., et al. (2026) · Gut Microbes Reports · doi:10.1080/29933935.2026.2674335
Perreau, C., Tomassi, D., Capronnier, O., Carton, T., Thabuis, C., & Guérin‐Deremaux, L. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1810842
Myco-foods and the gut microbiome: impacts of mycelial extracts, biomass, and mold-fermented foods
Keigler, J. I., Bell, J. M. L. N. D. M., & Marco, M. L. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2677948
Antonino, C., Faccia, M., Natrella, G., Caliandro, P., Sakkas, L., & Moatsou, G. A. (2026) · Applied Food Research · doi:10.1016/j.afres.2026.102228
Creedon, A. C., Bernard, H. M., Amati, F., Segata, N., Wallace, S. M., Arrè, A., Smith, H. A., Platts, A., Bulsiewicz, W. J., Bermingham, K. M., et al. (2026) · British Journal Of Nutrition · doi:10.1017/s0007114526107703 · Cited by 5
Xia, L., Xiong, X., Asem, A., Li, Z., & Ma, W. (2026) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2026.103158
Fujii, T., Takahashi, H., Ohno, E., Hirooka, Y., & Tochio, T. (2026) · Foods · doi:10.3390/foods15152631
Fats and Oils at the Nexus of Sustainability, Technology and Global Health
Martínez-Ávila, M., Valenzuela-Amaro, H. M., Cordero‐Clavijo, L. M., & López-Martínez, L. A. (2026) · Journal of the American Oil Chemists Society · doi:10.1002/aocs.70134
Zhang, Y., Liu, Z., Wang, X., Qin, Z., Ren, X., Zhang, T. X., He, C., Gu, J., & Jin, J. (2026) · Food & Function · doi:10.1039/d6fo03036j
Yoshida, K., Matsubara, T., Morita, S., Sakata, Y., Sonoki, H., & Miyaji, K. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1909212
Why probiotics fail: gut niche tension as the missing variable?
Печникова, Н. А., Zoikidou, O., Робертовна, Д. А., Choli‐Papadopoulou, T., Aggeli, A., & Yaremenko, A. V. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2728333
Venugopal, G., Jacob, A. A., Varghese, J. E., & Mattethra, G. C. (2026) · Comprehensive physiology · doi:10.1002/cph4.70278
Leonforte, F., Santanatoglia, A., Nicosia, V., Caprioli, G., Sagratini, G., & Mistretta, A. (2026) · Beverages · doi:10.3390/beverages12100124
Poole, A. C. (2025) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.15054013
Gorini, F., Tonacci, A., Gabriele, M., & Borghini, A. (2026) · Nutrients · doi:10.3390/nu18213535
Metadata
- Authors
- Healey, G., Murphy, R., Butts, C., Brough, L., Whelan, K., & Coad, J.
- Affiliations
- Plant & Food Research (NZ)
- University of Auckland (NZ)
- Massey University (NZ)
- King's College London (GB)
- Corresponding author
- Healey, Genelle
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2018-01-08
- Volume
- 119
- Issue
- 2
- Pages
- 176-189
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2782720493
- Cited by
- 267
- References
- 48
- Citations by year
- 2026: 30 · 2025: 43 · 2024: 38 · 2023: 37 · 2022: 48 · 2021: 22 · 2020: 21 · 2019: 21 · 2018: 6
- FWCI
- 14.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- dietary fiber intake, gut microbiota, inulin-type fructans, prebiotic supplementation, short-chain fatty acids, Bifidobacterium, Faecalibacterium, interindividual variability, dysbiosis, healthy adults
- MeSH terms
- Gastrointestinal Microbiome, Adult, Aged, Bacteria, Bifidobacterium, Dietary Fiber, Double-Blind Method, Fatty Acids, Volatile, Feces, Female, Humans, Inulin, Male, Middle Aged, New Zealand, Placebos, RNA, Ribosomal, 16S, Cross-Over Studies, Prebiotics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
