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Habitual dietary fibre intake influences gut microbiota response to an inulin-type fructan prebiotic: a randomised, double-blind, placebo-controlled, cross-over, human intervention study
Open accessAbstract
Dysbiotic gut microbiota have been implicated in human disease. Diet-based therapeutic strategies have been used to manipulate the gut microbiota towards a more favourable profile. However, it has been demonstrated that large inter-individual variability exists in gut microbiota response to a dietary intervention. The primary objective of this study was to investigate whether habitually low dietary fibre (LDF) v. high dietary fibre (HDF) intakes influence gut microbiota response to an inulin-type fructan prebiotic. In this randomised, double-blind, placebo-controlled, cross-over study, thirty-four healthy participants were classified as LDF or HDF consumers. Gut microbiota composition (16S rRNA bacterial gene sequencing) and SCFA concentrations were assessed following 3 weeks of daily prebiotic supplementation (Orafti® Synergy 1; 16 g/d) or placebo (Glucidex® 29 Premium; 16 g/d), as well as after 3 weeks of the alternative intervention, following a 3-week washout period. In the LDF group, the prebiotic intervention led to an increase in Bifidobacterium (P=0·001). In the HDF group, the prebiotic intervention led to an increase in Bifidobacterium (P<0·001) and Faecalibacterium (P=0·010) and decreases in Coprococcus (P=0·010), Dorea (P=0·043) and Ruminococcus (Lachnospiraceae family) (P=0·032). This study demonstrates that those with HDF intakes have a greater gut microbiota response and are therefore more likely to benefit from an inulin-type fructan prebiotic than those with LDF intakes. Future studies aiming to modulate the gut microbiota and improve host health, using an inulin-type fructan prebiotic, should take habitual dietary fibre intake into account.
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“In a prebiotic supplementation study, participants with high fiber intake at baseline showed a greater microbial response in response to an inulin-type fructan prebiotic than those with low habitual fiber intake (513).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [513]
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Metadata
- Authors
- Healey, G., Murphy, R., Butts, C., Brough, L., Whelan, K., & Coad, J.
- Affiliations
- Plant & Food Research (NZ)
- University of Auckland (NZ)
- Massey University (NZ)
- King's College London (GB)
- Corresponding author
- Healey, Genelle
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2018-01-08
- Volume
- 119
- Issue
- 2
- Pages
- 176-189
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2782720493
- Cited by
- 267
- References
- 48
- Citations by year
- 2026: 30 · 2025: 43 · 2024: 38 · 2023: 37 · 2022: 48 · 2021: 22 · 2020: 21 · 2019: 21 · 2018: 6
- FWCI
- 14.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- dietary fiber intake, gut microbiota, inulin-type fructans, prebiotic supplementation, short-chain fatty acids, Bifidobacterium, Faecalibacterium, interindividual variability, dysbiosis, healthy adults
- MeSH terms
- Gastrointestinal Microbiome, Adult, Aged, Bacteria, Bifidobacterium, Dietary Fiber, Double-Blind Method, Fatty Acids, Volatile, Feces, Female, Humans, Inulin, Male, Middle Aged, New Zealand, Placebos, RNA, Ribosomal, 16S, Cross-Over Studies, Prebiotics
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