Short-latency somatosensory evoked potentials in infantile autism: evidence of hyperactivity in the right primary somatosensory area
Open accessAbstract
Children with infantile autism sometimes show hyperesthesia or hypoesthesia to touch, pain, and/or temperature. To clarify the pathophysiology, we examined short-latency somatosensory evoked potentials (S-SEPs), elicited by median nerve stimulation, in 24 children with infantile autism (17 males, seven females; age range 2y 2mo-9y; mean age 4y 2mo [SD 1y 7mo]). We also evaluated relationships between S-SEP findings and clinical manifestations. Of the 24 children, 10 showed abnormal S-SEPs as follows: prolonged peak latency of N20 (n=2), extended interpeak latency of P13/14-N20 (n=7), appearance of a giant SEP (n=1), and a more than twofold right hemispheric peak-to-peak amplitude predominance of N20-P25 (n=5). In addition, a peak-to-peak amplitude of N20-P25 elicited by left median nerve stimuli was significantly higher than that obtained with right median nerve stimuli, which indicated right hemispheric hyperactivity relative to the left (p=0.008). Infantile autism is frequently associated with somatosensory abnormalities and right hemispheric hyperactivity relative to the left, especially in the primary somatosensory area. This is believed to contribute to the pathophysiology of infantile autism, especially the idiopathic form.
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In ASD, there is a greater disturbance in somatosensory response when stimulating the left vs. right median nerve.
“they observed a greater disturbance in the response when stimulating the left vs. right median nerve”
From Behavioral, Perceptual, and Neural Alterations in Sensory and Multisensory Function in Autism Spectrum Disorder (2015) · cites this paper as Miyazaki et al., 2007
Some children with ASD show abnormal somatosensory evoked potentials using median nerve stimulation.
“Using median nerve stimulation, Miyazaki and colleagues found that some children with ASD showed abnormal somatosensory evoked potentials (Miyazaki et al., 2007).”
From Behavioral, Perceptual, and Neural Alterations in Sensory and Multisensory Function in Autism Spectrum Disorder (2015) · cites this paper as Miyazaki et al., 2007
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- Authors
- Miyazaki, M., Fujii, E., Saijo, T., Mori, K., Hashimoto, T., Kagami, S., & Kuroda, Y.
- Affiliations
- Tokushima University (JP)
- Naruto University of Education (JP)
- Corresponding author
- Miyazaki, Masahito
- ORCID
- Kuroda, Yasuhiro
- Venue
- Developmental Medicine & Child Neurology
- Publisher
- Wiley
- Published
- 2006-12-21
- Volume
- 49
- Issue
- 1
- Pages
- 13-17
- ISSN
- 0012-1622 (ISSN-L)
- 1469-8749
- OpenAlex
- W2020382276
- Cited by
- 50
- References
- 18
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 8 · 2014: 3 · 2013: 4 · 2012: 1
- FWCI
- 0.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Developmental Medicine & Child Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Keywords
- infantile autism, short-latency somatosensory evoked potentials, primary somatosensory cortex, median nerve stimulation, interpeak latency prolongation, giant somatosensory evoked potentials, somatosensory abnormalities, idiopathic autism, pathophysiology
- MeSH terms
- Autistic Disorder, Child, Child, Preschool, Electroencephalography, Evoked Potentials, Somatosensory, Female, Humans, Hyperkinesis, Functional Laterality, Magnetic Resonance Imaging, Male, Severity of Illness Index, Somatosensory Cortex
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