The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Zinc and the immune system
Open accessAbstract
Zn is an essential trace element for all organisms. In human subjects body growth and development is strictly dependent on Zn. The nervous, reproductive and immune systems are particularly influenced by Zn deficiency, as well as by increased levels of Zn. The relationship between Zn and the immune system is complex, since there are four different types of influence associated with Zn. (1) The dietary intake and the resorption of Zn depends on the composition of the diet and also on age and disease status. (2) Zn is a cofactor in more than 300 enzymes influencing various organ functions having a secondary effect on the immune system. (3) Direct effects of Zn on the production, maturation and function of leucocytes. (4) Zn influences the function of immunostimulants used in the experimental systems. Here we summarize all four types of influence on the immune function. Nutritional aspects of Zn, the physiology of Zn, the influence of Zn on enzymes and cellular functions, direct effects of Zn on leucocytes at the cellular and molecular level, Zn-altered function of immunostimulants and the therapeutic use of Zn will be discussed in detail.
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Cites
Dimerization of cell surface receptors in signal transduction
Heldin, C.-H. (1995) · Cell · doi:10.1016/0092-8674(95)90404-2 · Cited by 1,634
Zinc and immune function: the biological basis of altered resistance to infection
Shankar, A. H., & Prasad, A. S. (1998) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.2.447s · Cited by 1,606
Admission criteria for immunogerontological studies in man: The senieur protocol
Ligthart, G. J., Corberand, J. X., Fournier, C., Galanaud, P., Hijmans, W., Kennes, B., Müller-Hermelink, H. K., & Steinmann, G. G. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90152-0 · Cited by 754 · cited 1×
“1982; Lighart et al .”
Crystal Structure of a Five-Finger GLI-DNA Complex: New Perspectives on Zinc Fingers
Pavletich, N. P., & Pabo, C. O. (1993) · Science · doi:10.1126/science.8378770 · Cited by 669
Sazawal, S., Black, R. E., Jalla, S., Mazumdar, S., Sinha, A., & Bhan, M. K. (1998) · Pediatrics · doi:10.1542/peds.102.1.1 · Cited by 543
CoREST: A functional corepressor required for regulation of neural-specific gene expression
Andrés, M. E., Burger, C., Peral-Rubio, M. J., Battaglioli, E., Anderson, M. E., Grimes, J., Dallman, J., Ballas, N., & Mandel, G. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9873 · Cited by 494
Butcher, S. K., Chahal, H., Nayak, L., Sinclair, A., Henriquez, N. V., Sapey, E., O'Mahony, D., & Lord, J. M. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.70.6.881 · Cited by 436
Serum thymulin in human zinc deficiency
Prasad, A. S., Meftah, S., Abdallah, J., Kaplan, J., Brewer, G. J., Bach, J. F., & Dardenne, M. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113717 · Cited by 335
Changes in apoptosis of human polymorphonuclear granulocytes with aging
Fülöp Jr, T., Fouquet, C., Allaire, P., Perrin, N., Lacombe, G., Stankova, J., Rola-Pleszczynski, M., Gagné, D., Wagner, J. R., Khalil, A., et al. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(96)01881-7 · Cited by 141
Zinc supplementation reconstitutes the production of interferon-α by leukocytes from elderly persons
CAKMAN, I., KIRCHNER, H., & RINK, L. (1997) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1997.17.469 · Cited by 121
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Cited by
The Essential Toxin: Impact of Zinc on Human Health
Plum, L. M., Rink, L., & Haase, H. (2010) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph7041342 · Cited by 1,577
Self-citationZinc and its role in immunity and inflammation
Bonaventura, P., Benedetti, G., Albarède, F., & Miossec, P. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.11.008 · Cited by 798
Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling
Jarosz, M., Olbert, M., Wyszogrodzka, G., Młyniec, K., & Librowski, T. (2017) · Inflammopharmacology · doi:10.1007/s10787-017-0309-4 · Cited by 733
From space to Earth: Advances in human physiology from 20 years of bed rest studies (1986–2006)
Pavy-Le Traon, A., Heer, M., Narici, M. V., Rittweger, J., & Vernikos, J. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0474-z · Cited by 658
Nutritional deficiencies after bariatric surgery
Bal, B. S., Finelli, F. C., Shope, T. R., & Koch, T. R. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.48 · Cited by 418
Metadata
- Authors
- Rink, L.
- Venue
- Proceedings of the Nutrition Society
- Publisher
- Cambridge University Press (CUP)
- Published
- 2000-11
- Volume
- 59
- Issue
- 4
- Pages
- 541-552
- ISSN
- 0029-6651 (ISSN-L)
- 1475-2719
- OpenAlex
- W2110630395
- Cited by
- 581
- References
- 11
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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