Cited by 364Fatty Acid Research and HealthInflammatory mediators and NSAID effectsEdible Oils Quality and Analysis

The DOI matches its Crossref record; 131 of the 135 references it cites were found in a registry or an index.

n -3 Fatty acids, inflammation and immunity: new mechanisms to explain old actions

Open access

Calder, Philip C.·2013·Proceedings of the Nutrition Society

Open this paper in CoChat — free account Open PDF

Abstract

Numerous effects of n -3 fatty acids EPA and DHA on functional responses of cells involved in inflammation and immunity have been described. Fatty acid-induced modifications in membrane order and in the availability of substrates for eicosanoid synthesis are long-standing mechanisms that are considered important in explaining the effects observed. More recently, effects on signal transduction pathways and on gene expression profiles have been identified. Over the last 10 years or so, significant advances in understanding the mechanisms of action of n -3 fatty acids have been made. These include the identification of new actions of lipid mediators that were already described and of novel interactions among those mediators and the description of an entirely new family of lipid mediators, resolvins and protectins that have anti-inflammatory actions and are critical to the resolution of inflammation. It is also recognised that EPA and DHA can inhibit activation of the prototypical inflammatory transcription factor NF-κB. Recent studies suggest three alternative mechanisms by which n -3 fatty acids might have this effect. Within T-cells, as well as other cells of relevance to immune and inflammatory responses, EPA and DHA act to disrupt very early events involving formation of the structures termed lipid rafts which bring together various proteins to form an effective signalling platform. In summary, recent research has identified a number of new mechanisms of action that help to explain previously identified effects of n -3 fatty acids on inflammation and immunity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1017/s0029665113001031

Cites

131 of 131 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Lipid rafts and signal transduction
Simons, K., & Toomre, D. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35036052 · Cited by 5,371
Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
Serhan, C. N., Chiang, N., & Van Dyke, T. E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2294 · Cited by 2,932
n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases
Calder, P. C. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1505s · Cited by 2,525
Self-citation
GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects
Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., & Olefsky, J. M. (2010) · Cell · doi:10.1016/j.cell.2010.07.041 · Cited by 2,428
Integrating cell-signalling pathways with NF-κB and IKK function
Perkins, N. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2083 · Cited by 2,350
The Effect of Dietary Supplementation with n—3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells
Endres, S., Ghorbani, R., Kelley, V. E., Georgilis, K., Lonnemann, G., van der Meer, J. W. M., Cannon, J. G., Rogers, T. S., Klempner, M. S., Weber, P. C., et al. (1989) · New England Journal of Medicine · doi:10.1056/nejm198902023200501 · Cited by 1,911
Resolvins
Serhan, C. N., Hong, S., Gronert, K., Colgan, S. P., Devchand, P. R., Mirick, G., & Moussignac, R.-L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020760 · Cited by 1,650
Omega‐3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?
Calder, P. C. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04374.x · Cited by 1,429
Self-citation
Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function
Lee, T. H., Hoover, R. L., Williams, J. D., Sperling, R. I., Ravalese, J., Spur, B. W., Robinson, D. R., Corey, E. J., Lewis, R. A., & Austen, K. F. (1985) · New England Journal of Medicine · doi:10.1056/nejm198505093121903 · Cited by 1,333
Saturated Fatty Acids, but Not Unsaturated Fatty Acids, Induce the Expression of Cyclooxygenase-2 Mediated through Toll-like Receptor 4
Lee, J. Y., Sohn, K. H., Rhee, S. H., & Hwang, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011695200 · Cited by 1,299

Show all 135 references

Research works printed but not linked: 1

Goldyne, 1981, Immunoregulatory properties of prostaglandins and related lipids, Crit Rev Immunol, 2, 189

Sorted by citations

Items 101–200 of 363

Omega-3 fatty acid supplementation may prevent loss of gray matter thickness in the left parieto-occipital cortex in first episode schizophrenia: A secondary outcome analysis of the OFFER randomized controlled study
Pawełczyk, T., Piątkowska-Janko, E., Bogorodzki, P., Gębski, P., Grancow-Grabka, M., Trafalska, E., Żurner, N., & Pawełczyk, A. M. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.10.013 · Cited by 40
A combination of omega-3 and plant sterols regulate glucose and lipid metabolism in individuals with impaired glucose regulation: A randomized and controlled clinical trial
Wang, J.-F., Zhang, H.-M., Li, Y.-Y., Xia, S., Wei, Y., Yang, L., Wang, D., Ye, J.-J., Li, H.-X., Yuan, J., et al. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-1048-x · Cited by 38
Nutrients and Bioactive Compounds in Seafood: Quantitative Literature Research Analysis
Durazzo, A., Lena, G. D., Gabrielli, P., Santini, A., Lombardi‐Boccia, G., & Lucarini, M. (2022) · Fishes · doi:10.3390/fishes7030132 · Cited by 42
Impact of DHA intake in a mouse model of synucleinopathy
Coulombe, K., Kerdiles, O., Tremblay, C., Émond, V., Lebel, M., Boulianne, A.-S., Plourde, M., Cicchetti, F., & Calon, F. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.12.002 · Cited by 38
Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content
Abou-Saleh, H., Ouhtit, A., Halade, G. V., & Rahman, M. M. (2019) · Nutrients · doi:10.3390/nu11112701 · Cited by 38
Maternal Nutritional Status and Development of Atopic Dermatitis in Their Offspring
Kang, C., Chiang, B., & Wang, L. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08780-y · Cited by 38
Fatty Acids, Lipid Emulsions and the Immune and Inflammatory Systems
Miles, E. A., & Calder, P. C. (2014) · World review of nutrition and dietetics · doi:10.1159/000365426 · Cited by 40
Self-citation
Endogenous Generation and Signaling Actions of Omega-3 Fatty Acid Electrophilic Derivatives
Cipollina, C. (2015) · BioMed Research International · doi:10.1155/2015/501792 · Cited by 39
Jussara (Euterpe edulisMart.) Supplementation during Pregnancy and Lactation Modulates the Gene and Protein Expression of Inflammation Biomarkers Induced bytrans-Fatty Acids in the Colon of Offspring
Morais, C. A., Oyama, L. M., de Oliveira, J. L., Garcia, M. C., de Rosso, V. V., Amigo, L. S. M., do Nascimento, C. M. O., & Pisani, L. P. (2014) · Mediators of Inflammation · doi:10.1155/2014/987927 · Cited by 37
Maternal Overnutrition Programs Central Inflammation and Addiction-Like Behavior in Offspring
Montalvo-Martínez, L., Maldonado‐Ruiz, R., Cárdenas‐Tueme, M., Reséndez‐Pérez, D., & Camacho‐Morales, A. (2018) · BioMed Research International · doi:10.1155/2018/8061389 · Cited by 42
Is Oral Omega-3 Effective in Reducing Mucocutaneous Side Effects of Isotretinoin in Patients with Acne Vulgaris?
Mirnezami, M., & Rahimi, H. (2018) · Dermatology Research and Practice · doi:10.1155/2018/6974045 · Cited by 36
Omega-6 Polyunsaturated Fatty Acids Enhance Tumor Aggressiveness in Experimental Lung Cancer Model: Important Role of Oxylipins
Montecillo-Aguado, M. R., Tirado-Rodríguez, B., Antonio-Andrés, G., Morales-Martínez, M., Tong, Z., Yang, J., Hammock, B. D., Hernández‐Pando, R., & Huerta‐Yépez, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116179 · Cited by 36
Maternal Malnutrition in the Etiopathogenesis of Psychiatric Diseases: Role of Polyunsaturated Fatty Acids
Morgese, M. G., & Trabace, L. (2016) · Brain Sciences · doi:10.3390/brainsci6030024 · Cited by 40
Oxidative stress reduction related to the efficacy of n-3 polyunsaturated fatty acids in first episode schizophrenia: Secondary outcome analysis of the OFFER randomized trial
Pawełczyk, T., Grancow-Grabka, M., Trafalska, E., Szemraj, J., & Pawełczyk, A. M. (2017) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2017.05.004 · Cited by 35
Central Modulation of Neuroinflammation by Neuropeptides and Energy-Sensing Hormones during Obesity
Maldonado‐Ruiz, R., Fuentes‐Mera, L., & Camacho‐Morales, A. (2017) · BioMed Research International · doi:10.1155/2017/7949582 · Cited by 37
Effects of DHA-rich fish oil supplementation on the lipid profile, markers of muscle damage, and neutrophil function in wheelchair basketball athletes before and after acute exercise
Marques, C. G., Santos, V. C., Levada‐Pires, A. C., Jacintho, T. M., Gorjão, R., Pithon‐Curi, T. C., & Cury‐Boaventura, M. F. (2015) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2014-0140 · Cited by 34
Environmental (Lifestyle) Risk Factors for LADA
Carlsson, S. (2019) · Current Diabetes Reviews · doi:10.2174/1573399814666180716150253 · Cited by 34
The association between n‐3 polyunsaturated fatty acid intakes and asthma in US children and adolescents: A cross‐sectional study from NHANES
Zhang, X., Han, Y., Tian, Q., Du, L., Chen, L., Zhang, Y., Guo, X., & Li, X. (2023) · Pediatric Allergy and Immunology · doi:10.1111/pai.14024 · Cited by 34
n–3 Long-chain PUFAs reduce respiratory morbidity caused by iron supplementation in iron-deficient South African schoolchildren: a randomized, double-blind, placebo-controlled intervention
Malan, L., Baumgartner, J., Calder, P. C., Zimmermann, M. B., & Smuts, C. M. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.081208 · Cited by 34
Self-citation
Marine fish oil is more potent than plant-based n-3 polyunsaturated fatty acids in the prevention of mammary tumors
Liu, J., Abdelmagid, S. A., Pinelli, C. J., Monk, J. M., Liddle, D. M., Hillyer, L. M., Hucik, B., Silva, A., Subedi, S. D., Wood, G. A., et al. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.12.011 · Cited by 33
Effects of Different Lipophilized Ferulate Esters in Fish Oil-Enriched Milk: Partitioning, Interaction, Protein, and Lipid Oxidation
Qiu, X., Jacobsen, C., Villeneuve, P., Durand, E., & Sørensen, A. M. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b02994 · Cited by 33
Evaluation of the impact of camelina oil-containing diets on the expression of genes involved in the innate anti-viral immune response in Atlantic cod (Gadus morhua)
Booman, M., Xu, Q., & Rise, M. L. (2014) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2014.05.017 · Cited by 32
Role of omega-3 polyunsaturated fatty acids in preventing gastrointestinal cancers: current status and future perspectives
Lee, H.-J., Han, Y., An, J. M., Kang, E. A., Park, Y. J., Cha, J.-Y., & Hahm, K. B. (2018) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2018.1524299 · Cited by 33
Omega-3 Fatty Acid Supplementation, Pro-Resolving Mediators, and Clinical Outcomes in Maternal-Infant Pairs
Nordgren, T. M., Anderson‐Berry, A., Ormer, M. V., Zoucha, S., Elliott, E., Johnson, R., McGinn, E. A., Cave, C., Rilett, K., Weishaar, K., et al. (2019) · Nutrients · doi:10.3390/nu11010098 · Cited by 32
Effect of different concentrations of omega-3 fatty acids on stimulated THP-1 macrophages
Allam‐Ndoul, B., Guénard, F., Barbier, O., & Vohl, M. (2017) · Genes & Nutrition · doi:10.1186/s12263-017-0554-6 · Cited by 32
Genomic, Transcriptomic, and Epigenomic Features Differentiate Genes That Are Relevant for Muscular Polyunsaturated Fatty Acids in the Common Carp
Zhang, H., Xu, P., Jiang, Y., Zhao, Z., Feng, J., Tai, R., Dong, C., & Xu, J. H. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00217 · Cited by 32
Omega-3 fatty acids and inflammation: A perspective on the challenges of evaluating efficacy in clinical research
Skulas‐Ray, A. C. (2015) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2015.02.001 · Cited by 31
Prenatal Omega-3 and Omega-6 Polyunsaturated Fatty Acids and Childhood Atopic Dermatitis
Gardner, K. G., Gebretsadik, T. S., Hartman, T. J., Rosa, M. J., Tylavsky, F. A., Adgent, M. A., Moore, P. E., Koçak, M., Bush, N. R., Davis, R. L., et al. (2019) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2019.09.031 · Cited by 32
Fish-oil supplementation decreases Indoleamine-2,3-Dioxygenase expression and increases hippocampal serotonin levels in the LPS depression model
Carabelli, B., Delattre, A. M., Waltrick, A. P. F., Araújo, G., Suchecki, D., Machado, R. B., de Souza, L. E. R., Zanata, S. M., Zanoveli, J. M., & Ferraz, A. C. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112675 · Cited by 34
N -Docosahexaenoyl Dopamine, an Endocannabinoid-like Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, Attenuates Lipopolysaccharide-Induced Activation of Microglia and Macrophages via COX-2
Wang, Y., Plastina, P., Vincken, J., Jansen, R., Balvers, M. G. J., ten Klooster, J. P., Gruppen, H., Witkamp, R. F., & Meijerink, J. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00298 · Cited by 31
Oxidative Stability and Shelf Life of Fish Oil
Mozūraitytė, R., Kristinová, V., Standal, I. B., Carvajal, A. K., & Aursand, M. (2016) · Elsevier eBooks · doi:10.1016/b978-1-63067-056-6.00005-7 · Cited by 30
The impact of an omega-3 fatty acid rich lipid emulsion on fatty acid profiles in critically ill septic patients
Hall, T. C., Bilku, D. K., Neal, C. P., Cooke, J., Fisk, H. L., Calder, P. C., & Dennison, A. R. (2016) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2016.07.001 · Cited by 31
Self-citation
Effects of Dietary n-6:n-3 PUFA Ratios on Lipid Levels and Fatty Acid Profile of Cherry Valley Ducks at 15–42 Days of Age
Li, M., Zhai, S., Xie, Q., Tian, L., Li, X., Zhang, J., Ye, H., Zhu, Y., Yang, L., & Wang, W. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b02918 · Cited by 30
Microbiome Therapeutics: A Path Toward Sustainable Healthcare
Kumar, T., & Chauhan, N. S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00010-3 · Cited by 29
Relationship of Omega-3 fatty acids DHA and EPA with the inflammatory biomarker hs-CRP in children with sickle cell anemia
Setty, Y. B. N., Betal, S. G., Miller, R. E., Brown, D. S., Meier, M., Cahill, M., Lerner, N. B., Apollonsky, N., & Stuart, M. J. (2019) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2019.05.004 · Cited by 30
Maternal pre-pregnancy weight status modifies the influence of PUFAs and inflammatory biomarkers in breastmilk on infant growth
Nuss, H., Altazan, A. D., Zabaleta, J., SOTHERN, M. S., & Redman, L. M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217085 · Cited by 29
Cardiac mitochondrial function, nitric oxide sensitivity and lipid composition following hypoxia acclimation in sablefish
Gerber, L., Clow, K. A., Katan, T., Emam, M., Leeuwis, R. H. J., Parrish, C. C., & Gamperl, A. K. (2019) · Journal of Experimental Biology · doi:10.1242/jeb.208074 · Cited by 29
Impact of Varying Dosages of Fish Oil on Recovery and Soreness Following Eccentric Exercise
VanDusseldorp, T. A., Escobar, K. A., Johnson, K. E., Stratton, M. T., Moriarty, T. A., Kerksick, C. M., Mangine, G. T., Holmes, A. J., Lee, M., Endito, M. R., et al. (2020) · Nutrients · doi:10.3390/nu12082246 · Cited by 31
Proximate composition and lipid profile of red mullet (Mullus barbatus) from two sites of the Tyrrhenian and Adriatic seas (Italy): a seasonal differentiation
Lena, G. D., Nevigato, T., Rampacci, M., Casini, I., Caproni, R., & Orban, E. (2015) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2015.10.003 · Cited by 29
Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases
Al‐Taan, O., Stephenson, J. A., Spencer, L., Pollard, C. A., West, A. L., Calder, P. C., Metcalfe, M. S., & Dennison, A. R. (2013) · Lipids in Health and Disease · doi:10.1186/1476-511x-12-64 · Cited by 28
Self-citation
The immune-related fatty acids are responsive to CO2 driven seawater acidification in a crustacean brine shrimp Artemia sinica
Gao, Y., Zheng, S., Zheng, C., Shi, Y.-C., Xie, X., Wang, K.-J., & Liu, H.-P. (2017) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2017.12.022 · Cited by 28
Hnf4α is involved in the regulation of vertebrate LC-PUFA biosynthesis: insights into the regulatory role of Hnf4α on expression of liver fatty acyl desaturases in the marine teleost Siganus canaliculatus
Wang, S., Chen, J., Jiang, D., Zhang, Q., You, C., Tocher, D. R., Monroig, Ó., Dong, Y., & Li, Y. (2018) · Fish Physiology and Biochemistry · doi:10.1007/s10695-018-0470-8 · Cited by 28
Resolution of inflammation: Intervention strategies and future applications
Panezai, J., & Dyke, T. E. V. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.116089 · Cited by 30
Liver Transcriptome Profiling Reveals That Dietary DHA and EPA Levels Influence Suites of Genes Involved in Metabolism, Redox Homeostasis, and Immune Function in Atlantic Salmon (Salmo salar)
Xue, X., Hall, J. R., Caballero‐Solares, A., Eslamloo, K., Taylor, R. G., Parrish, C. C., & Rise, M. L. (2020) · Marine Biotechnology · doi:10.1007/s10126-020-09950-x · Cited by 28
The role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by SARS-CoV-2 infection: A perspective for COVID-19 therapy
Hasankhani, A., Bahrami, A., Tavakoli‐Far, B., Iranshahi, S., Ghaemi, F., Akbarizadeh, M. R., Amin, A. H., Kiasari, B. A., & Shabestari, A. M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1127358 · Cited by 28
Docosahexaenoic acid promotes micron scale liquid-ordered domains. A comparison study of docosahexaenoic versus oleic acid containing phosphatidylcholine in raft-like mixtures
Georgieva, R., Chachaty, C., Hazarosova, R., Tessier, C., Nuss, P., Momchilova, A., & Staneva, G. (2015) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2015.02.027 · Cited by 26
Fish consumption and the risk of cardiovascular disease and mortality in patients with type 2 diabetes: a dose-response meta-analysis of prospective cohort studies
Jayedi, A., Soltani, S., Abdolshahi, A., & Shab‐Bidar, S. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1764486 · Cited by 27
Early life infection and proinflammatory, atherogenic metabolomic and lipidomic profiles in infancy: a population-based cohort study
Mansell, T., Saffery, R., Burugupalli, S., Ponsonby, A., Tang, M. L. K., O’Hely, M., Bekkering, S., Smith, A., Rowland, R., Ranganathan, S., et al. (2022) · eLife · doi:10.7554/elife.75170 · Cited by 26
Microalgae as Raw Materials for Aquafeeds: Growth Kinetics and Improvement Strategies of Polyunsaturated Fatty Acids Production
Soto-Sánchez, O., Hidalgo, P., González, A., Oliveira, P. E., Hernández, A. J., & Dantagnan, P. (2023) · Aquaculture Nutrition · doi:10.1155/2023/5110281 · Cited by 34
Alpha-linolenic acid modulates systemic and adipose tissue-specific insulin sensitivity, inflammation, and the endocannabinoid system in dairy cows
Kra, G., Daddam, J. R., Moallem, U., Kamer, H., Mualem, B., Levin, Y., Kočvarová, R., Nemirovski, A., Contreras, A. G., Tam, J., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-32433-7 · Cited by 26
Fatty fish consumption and risk of latent autoimmune diabetes in adults
Löfvenborg, J. E., Andersson, T., Carlsson, P. ‐., Dorkhan, M., Groop, L., Martinell, M., Tuomilehto, J., Wolk, A., & Carlsson, S. (2014) · Nutrition and Diabetes · doi:10.1038/nutd.2014.36 · Cited by 26
A Higher Dietary Ratio of Long-Chain Omega-3 to Total Omega-6 Fatty Acids for Prevention of COX-2-Dependent Adenocarcinomas
DiNicolantonio, J. J., McCarty, M. F., Chatterjee, S., Lavie, C. J., & O’Keefe, J. H. (2014) · Nutrition and Cancer · doi:10.1080/01635581.2014.956262 · Cited by 26
Impact of health and lifestyle food supplements on periodontal tissues and health
Spahr, A., & Divnic‐Resnik, T. (2022) · Periodontology 2000 · doi:10.1111/prd.12455 · Cited by 28
Polyunsaturated Fatty Acid Metabolism in the Brain and Brain Cells
Joffre, C. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.88232 · Cited by 30
The differential effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on seizure frequency in patients with drug-resistant epilepsy — A randomized, double-blind, placebo-controlled trial
Ibrahim, F. A. S., Ghebremeskel, K., Abdel‐Rahman, M. E., Ahmed, A. A. M., Mohmed, I. M., Osman, G., Elseed, M. A., Hamed, A. A., Rabinowicz, A. L., Salih, M. A. M., et al. (2018) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2018.08.016 · Cited by 25
Effects of a sea buckthorn oil spray emulsion on dry eye
Larmo, P. S., Järvinen, R., Laihia, J. K., Löyttyniemi, E., Maavirta, L., Yang, B., Kallio, H. P. T., & Sandberg-Lall, M. (2018) · Contact Lens and Anterior Eye · doi:10.1016/j.clae.2018.11.011 · Cited by 24
Recent developments, challenges, and prospects of dietary omega-3 PUFA-fortified foods: Focusing on their effects on cardiovascular diseases
Wang, Y., Wu, G., Wang, Y., Rehman, A., Yu, L., Zhang, H., Jin, Q., Suleria, H. A. R., & Wang, X. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.142498 · Cited by 25
Identification of very long-chain (>C24) fatty acid methyl esters using gas chromatography coupled to quadrupole/time-of-flight mass spectrometry with atmospheric pressure chemical ionization source
Garlito, B., Portolés, T., Niessen, W. M. A., Navarro, J. C., Hontoria, F., Monroig, Ó., Varó, I., & Serrano, R. (2018) · Analytica Chimica Acta · doi:10.1016/j.aca.2018.11.001 · Cited by 25
High Endogenously Synthesized N-3 Polyunsaturated Fatty Acids in Fat-1 Mice Attenuate High-Fat Diet-Induced Insulin Resistance by Inhibiting NLRP3 Inflammasome Activation via Akt/GSK-3β/TXNIP Pathway
Zhu, P., Zhang, J., Yi, C., Yang, Y., Wang, F., Gu, K.-P., Yang, H., Wang, Y., & Zou, Z. (2022) · Molecules · doi:10.3390/molecules27196384 · Cited by 25
Linoleic acid and stearic acid elicit opposite effects on AgRP expression and secretion via TLR4-dependent signaling pathways in immortalized hypothalamic N38 cells
Wang, S., Xiang, N., Yang, L., Zhu, C., Zhu, X., Wang, L., Gao, P., Xi, Q., Zhang, Y., Shu, G., et al. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.02.031 · Cited by 22
Changes of visceral properties and digestive enzymes in the herbivorous marine teleost Siganus canaliculatus fed on different diets
Xie, D., Xu, S., Wu, Q., Chen, F., Wang, S., You, C., & Li, Y. (2018) · Acta Oceanologica Sinica · doi:10.1007/s13131-018-1165-9 · Cited by 22
An overview of nutritional strategies for recovery process in sports-related muscle injuries
Quintero, K. J., Resende, A. D. S., Leite, G. S. F., & Lancha, A. H. (2018) · Nutrire · doi:10.1186/s41110-018-0084-z · Cited by 23
Uncovering mechanisms of brain inflammation in Alzheimer's disease with APOE4 : Application of single cell‐type lipidomics
Asante, I., Louie, S. G., & Yassine, H. N. (2022) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14907 · Cited by 23
The effect of dietary fat on fatty acid composition, gene expression and vitamin status in pre-ruminant calves
Tsai, C., Rezamand, P., Loucks, W. I., Scholte, C. M., & Doumit, M. E. (2017) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2017.05.004 · Cited by 22
Inhibitory activity of flaxseed oil against CdCl2 induced liver and kidney damage: Histopathology, genotoxicity, and gene expression study
Diab, K. A. E., Ibrahim, N. E., Fahmy, M. A., Hassan, E. M., & Omara, E. A. A. (2020) · Toxicology Reports · doi:10.1016/j.toxrep.2020.08.023 · Cited by 22
Use of industrial hemp byproducts in ruminants: a review of the nutritional profile, animal response, constraints, and global regulatory environment
Irawan, A., Buffington, H., Ateş, S., & Bionaz, M. (2025) · Journal of Cannabis Research · doi:10.1186/s42238-025-00279-7 · Cited by 22
Effects of dietary n-3 fatty acids on Toll-like receptor activation in primary leucocytes from Atlantic salmon (Salmo salar)
Arnemo, M., Kavaliauskis, A., Andresen, A. M. S., Bou, M., Berge, G. M., Ruyter, B., & Gjøen, T. (2017) · Fish Physiology and Biochemistry · doi:10.1007/s10695-017-0353-4 · Cited by 20
A Combination of Mediterranean and Low-FODMAP Diets for Managing IBS Symptoms? Ask Your Gut!
Kasti, A. N., Petsis, K., Lambrinou, S., Katsas, K., Nikolaki, M. D., Papanikolaou, I. S., Hatziagelaki, E. E., & Τriantafyllou, Κ. (2022) · Microorganisms · doi:10.3390/microorganisms10040751 · Cited by 24
The effectiveness of omega‐3 fatty acids on health outcomes in women with breast cancer: A systematic review
Osouli‐Tabrizi, S., Mehdizadeh, A., Naghdi, M., Sanaat, Z., Vahed, N., & Farshbaf‐Khalili, A. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3409 · Cited by 19
Effects of dietary n-3 LC-PUFA levels on the growth, immunity, and lipid metabolism of freshwater carnivorous teleost largemouth bass (Micropterus salmoides) juveniles
An, W., Xu, J., Chen, F., Ma, Y., Su, Z. W., Guang, J., Su, N., Zhang, G., Xu, C., Li, Y., et al. (2023) · Aquaculture Reports · doi:10.1016/j.aqrep.2023.101704 · Cited by 20
The Healing Cascade: Facilitating and Optimizing the System.
Rand, E., & Gellhorn, A. (2016) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2016.07.001 · Cited by 19
Effect of dietary supplementation with filamentous microalga Tribonema ultriculosum on growth performance, fillet quality and immunity of rainbow trout Oncorhynchus mykiss
Chen, W., Luo, L., Han, D., Long, F., Chi, Q., & Hu, Q. (2021) · Aquaculture Nutrition · doi:10.1111/anu.13264 · Cited by 17
N-3 polyunsaturated fatty acids and clozapine abrogates poly I: C-induced immune alterations in primary hippocampal neurons
Ribeiro, B. M. M., Filho, A. J. M. C., Costa, D. V. D. S., Menezes, A. T., da Fonseca, A. C. C., Gama, C. S., Moura‐Neto, V., de Lucena, D. F., Vale, M. L., & Macêdo, D. S. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.11.022 · Cited by 19
Influence of aquaculture waste on fatty acid profiles and gonad maturation of wild fish aggregations at fish farms
González‐Silvera, D., Izquierdo-Gómez, D., Sánchez‐Jerez, P., Elbal, M. T., López-Jiménez, J. A., & Martínez-López, F. J. (2020) · Marine Environmental Research · doi:10.1016/j.marenvres.2020.104902 · Cited by 18
Children’s erythrocyte fatty acids are associated with the risk of islet autoimmunity
Niinistö, S., Erlund, I., Lee, H., Uusitalo, U. M., Salminen, I., Aronsson, C. A., Parikh, H. M., Liu, X., Hummel, S., Toppari, J., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-82200-9 · Cited by 18
EPA and DHA Fatty Acids Induce a Remodeling of Tumor Vasculature and Potentiate Docetaxel Activity
Goupille, C., Vibet, S., Frank, P. G., & Mahéo, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144965 · Cited by 17
Maternal intake of fatty acids and their food sources during lactation and the risk of preclinical and clinical type 1 diabetes in the offspring
Niinistö, S., Takkinen, H.-M., Uusitalo, L., Rautanen, J., Vainio, N., Ahonen, S., Nevalainen, J., Kenward, M. G., Lumia, M., Simell, O., et al. (2015) · Acta Diabetologica · doi:10.1007/s00592-014-0673-0 · Cited by 16
Omega-3 Index as a Sport Biomarker: Implications for Cardiovascular Health, Injury Prevention, and Athletic Performance
Medoro, A., Buonsenso, A., Centorbi, M., Calcagno, G., Scapagnini, G., Fiorilli, G., & Davinelli, S. (2024) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk9020091 · Cited by 22
Evidence on n-3 Fatty Acids and Oleic Acid Role in Retinal Inflammation and Microvascular Integrity: Insight from a Hyperlipidemic Rat Model
Bettadahalli, S., Acharya, P., & Talahalli, R. R. (2020) · Inflammation · doi:10.1007/s10753-019-01172-1 · Cited by 15
Lifestyle or Environmental Influences and Their Interaction With Genetic Susceptibility on the Risk of LADA
Carlsson, S. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.917850 · Cited by 16
Evidence for a role of proteins, lipids, and phytochemicals in the prevention of polycystic kidney disease progression and severity
Maditz, K. H., Gigliotti, J. C., & Tou, J. C. L. (2013) · Nutrition Reviews · doi:10.1111/nure.12085 · Cited by 15
Natural product derived immune-regulatory agents
Talmadge, J. E. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.02.025 · Cited by 15
n‐3 PUFA Induce Microvascular Protective Changes During Ischemia/Reperfusion
de Souza, M. D. G. C., Conde, C. M. S., Laflôr, C. M., Sicuro, F. L., & Bouskela, E. (2014) · Lipids · doi:10.1007/s11745-014-3961-0 · Cited by 15
Worms and welfare: Behavioural and physiological changes associated with gastrointestinal nematode parasitism in lambs
Hempstead, M. N., Waghorn, T. S., Gibson, M. J., Sauermann, C. W., Ross, A. B., Cave, V. M., Sutherland, M. A., Marquetoux, N., Hannaford, R., Corner-Thomas, R. A., et al. (2023) · Veterinary Parasitology · doi:10.1016/j.vetpar.2023.110056 · Cited by 14
Effect of Three-spot Seahorse Petroleum Ether Extract on Lipopolysaccharide Induced Macrophage RAW264.7 Inflammatory Cytokine Nitric Oxide and Composition Analysis
Chen, L., Shen, X., Chen, G., Cao, X., & Yang, J. (2015) · Journal of Oleo Science · doi:10.5650/jos.ess15092 · Cited by 14
Mannoside Glycolipid Conjugates Display Anti-inflammatory Activity by Inhibition of Toll-like Receptor-4 Mediated Cell Activation
Flacher, V., Neuberg, P., Point, F., Daubeuf, F., Muller, Q., Sigwalt, D., Fauny, J., Rémy, J.-S., Frossard, N., Wagner, A., et al. (2015) · ACS Chemical Biology · doi:10.1021/acschembio.5b00552 · Cited by 14
Diet and Respiratory Infections: Specific or Generalized Associations?
Vu, T. T., Horn, L. V., Achenbach, C. J., Rydland, K., & Cornelis, M. C. (2022) · Nutrients · doi:10.3390/nu14061195 · Cited by 16
The Omega-3 Fatty Acid Docosahexaenoic Acid Modulates Inflammatory Mediator Release in Human Alveolar Cells Exposed to Bronchoalveolar Lavage Fluid of ARDS Patients
Cotogni, P., Trombetta, A., Muzio, G., Maggiora, M., & Canuto, R. A. (2015) · BioMed Research International · doi:10.1155/2015/642520 · Cited by 14
Omega-3 and Prostate Cancer: Examining the Pertinent Evidence
McCarty, M. F., DiNicolantonio, J. J., Lavie, C. J., & O’Keefe, J. H. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.10.029 · Cited by 14
Recent developments in lipid metabolism in ruminants – the role of fat in maintaining animal health and performance
Hiller, B. (2014) · Animal Production Science · doi:10.1071/an14555 · Cited by 16
Effect of fish-oil supplementation on breastmilk long-chain polyunsaturated fatty acid concentration: a randomized controlled trial in rural Ethiopia
Argaw, A., Bouckaert, K. P., Wondafrash, M., Kolsteren, P. W., Lachat, C. K., Meulenaer, B. D., Hanley‐Cook, G., & Huybregts, L. (2020) · European Journal of Clinical Nutrition · doi:10.1038/s41430-020-00798-x · Cited by 14
Effects of dietary supplementation with filamentous microalgae (Oedocladium sp. or Tribonema ultriculosum) on growth performance, fillet fatty acid composition, skin pigmentation, and immune response of yellow catfish Pelteobagrus fulvidraco
Chen, W., Wang, Y., Han, D., Han, D. H., Zhu, X., Xie, S., Long, F., Jia, J., & Hu, Q. (2021) · Journal of the World Aquaculture Society · doi:10.1111/jwas.12839 · Cited by 13
Tomato-Free wonder sauce: A functional product with health-boosting properties
El-Haggar, E. F., Mahmoud, K. F., ramadan, M. M., & Zahran, H. A. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105758 · Cited by 13
Influence of tropical reservoirs eutrophication on the polyunsaturated fatty acid profile in Astyanax altiparanae (Pisces: Characidae)
Marques, V. H., Moreira, R. G., & Gomes, A. D. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.137182 · Cited by 13
It Is Time for an Oil Change: Polyunsaturated Fatty Acids and Human Health.
Powell, N., Chaudhary, S., & Zaidi, A. (2021) · PubMed Central · Cited by 13
Polyunsaturated Fatty Acids on Cardiovascular Health: Revealing Potentials of Functional Food
Drenjančević, I., Kralik, G., Kralik, Z., Mihalj, M., Stupin, A., Novak, S., & Grčević, M. (2017) · InTech eBooks · doi:10.5772/67033 · Cited by 13
Actions of Cannabis sativa L. fixed oil and nano-emulsion on venom-induced inflammation of Bothrops moojeni snake in rats
Carvalho, H. D. O., Gonçalves, D. E. S., Picanço, K. R. T., dos Santos, A. V. T. D. L. T., Lúcia, M., Hu, X., Fernandes, C. P., Ferreira, I. M., & Carvalho, J. C. T. (2020) · Inflammopharmacology · doi:10.1007/s10787-020-00754-y · Cited by 13
The effect of omega-3 polyunsaturated fatty acid intake on blood levels of omega-3s in people with chronic atherosclerotic disease: a systematic review
Nayda, N. C., Thomas, J. M., Delaney, C. L., & Miller, M. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuad020 · Cited by 13
Fatty acids and their metabolites (resolvins) are altered in women with gestational diabetes mellitus (GDM)
Joshi, N. P., Jadhav, A. T., Godhamgaonkar, A. A., Sundrani, D. P., Randhir, K., Pisal, H., Wagh, G. N., Krishnaveni, G. V., Gupte, S., & Joshi, S. (2024) · Food & Function · doi:10.1039/d3fo05348b · Cited by 13
Determination of red blood cell fatty acid profiles: Rapid and high-confident analysis by chemical ionization-gas chromatography-tandem mass spectrometry
Schober, Y., Wahl, H. G., Renz, H., & Nockher, W. A. (2016) · Journal of Chromatography B · doi:10.1016/j.jchromb.2016.11.019 · Cited by 12

Authors: Calder, P. C.
Affiliations: University of Southampton (GB)
Corresponding author: Calder, Philip C.
ORCID: Calder, Philip C.
Venue: Proceedings of the Nutrition Society
Publisher: Cambridge University Press (CUP)
Published: 2013-05-14
Volume: 72
Issue: 3
Pages: 326-336
ISSN: 0029-6651 (ISSN-L)
1475-2719
DOI: 10.1017/s0029665113001031
OpenAlex: W2167822367
Cited by: 364
References: 135
Citations by year: 2026: 14 · 2025: 14 · 2024: 17 · 2023: 32 · 2022: 21 · 2021: 22 · 2020: 45 · 2019: 27 · 2018: 32 · 2017: 37 · 2016: 30 · 2015: 38 · 2014: 28 · 2013: 7
FWCI: 3.86
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified)
Locations: Proceedings of The Nutrition Society (publishedVersion)
PubMed (publishedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
Funders: Mead Johnson Nutrition
Danone
Amarin Corporation
Vifor Pharma
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
Keywords: omega-3 fatty acids, eicosapentaenoic acid, docosahexaenoic acid, inflammation, immunity, membrane order, eicosanoid biosynthesis, signal transduction, gene expression, resolvins, protectins, lipid mediators, inflammation resolution, NF-κB, lipid rafts, T cells
MeSH terms: Animals, Humans, Immune System, Inflammation, Signal Transduction, Fatty Acids, Omega-3, NF-kappa B, Membrane Microdomains

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

n -3 Fatty acids, inflammation and immunity: new mechanisms to explain old actions

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks