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Cited by 137Eating Disorders and BehaviorsBipolar Disorder and TreatmentMental Health Research Topics

A controlled family history study of bulimia

Hudson, James I., Pope, Harrison G., Jonas, Jeffrey M., Yurgelun-Todd, Deborah, Frankenburg, Frances R.·1987·Psychological Medicine
DOI 10.1017/s0033291700000684
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Abstract

Using the family history method, we assessed the morbid risk for psychiatric disorders in the first-degree relatives of 69 probands with bulimia, 24 probands with major depression, and 28 nonpsychiatric control probands. The morbid risk for major affective disorder among the first-degree relatives of the bulimic probands was 32%, significantly greater than that found in the nonpsychiatric control probands. The rate of familial major affective disorder was significantly greater in bulimic probands who had a history of major affective disorder themselves than in bulimic probands without such a history - but the latter group, in turn, displayed significantly higher rates than the nonpsychiatric control probands. Eating disorders were slightly, but not significantly, more prevalent in the families of bulimic probands than nonpsychiatric control probands. We present two alternative hypotheses which might explain these findings.

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  • Family studies have shown significantly increased prevalence of eating disorders in relatives of probands with anorexia nervosa compared to relatives of control probands.

    “Family studies have shown significantly increased prevalence of eating disorders in relatives of probands with AN, compared to relatives of control probands (Gershon et al. 1983; Strober et al. 1985; Hudson et al. 1987; Lilenfeld et al. 1998), thereby providing evidence for the familiality of eating disorders.”

    From Evidence for a Susceptibility Gene for Anorexia Nervosa on Chromosome 1 (2002) · cites this paper as Hudson et al. 1987

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Authors
Hudson, J. I., Pope, H. G., Jonas, J. M., Yurgelun-Todd, D., & Frankenburg, F. R.
Affiliations
Harvard University (US)
Corresponding author
Hudson, James I.
ORCID
Venue
Psychological Medicine
Publisher
Cambridge University Press (CUP)
Published
1987-11
Volume
17
Issue
4
Pages
883-890
ISSN
  • 0033-2917 (ISSN-L)
  • 1469-8978
DOI
10.1017/s0033291700000684
OpenAlex
W2071287240
Cited by
137
References
40
Citations by year
2025: 1 · 2024: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 2
FWCI
7.08
Type
journal article
Language
en
Open access
closed
Licence
www.cambridge.org/core/terms (unspecified, 7921 d)
Locations
  • Psychological Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (MH-36224)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
Keywords
bulimia nervosa, family history (medicine), first-degree relatives, major affective disorders, major depressive disorder, eating disorders, familial risk, genetic susceptibility, probands
MeSH terms
Adolescent, Adult, Anorexia Nervosa, Bulimia, Depressive Disorder, Female, Humans, Manuals as Topic, Middle Aged, Risk Factors, Substance-Related Disorders

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