Positron emission tomography imaging in depression: a neural systems perspective
Abstract
PET measures of regional glucose metabolism, although chemically nonspecific, are sensitive indices of brain function in the untreated state and following disparate treatments. The continued development of imaging and multivariate statistical strategies is expected to provide an important perspective toward the full characterization of the depression phenotype at the neural systems level. An additional goal is the development of routine, brain-based clinical algorithms that optimize diagnosis and treatment of individual depressed patients.
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The subgenual (or subcallosal) cingulate cortex has been implicated in depression, and electrical stimulation in that region may relieve depression, although it has not been possible to confirm this in a double-blind study.
“The subgenual (or subcallosal) cingulate cortex has been implicated in depression, and electrical stimulation in that region may relieve depression (Mayberg, 2003; Hamani et al., 2009, 2011; Lozano et al., 2012; Laxton et al., 2013; Lujan et al., 2013) [although it has not been possible to confirm this in a double-blind study (Holtzheimer et al., 2017)].”
From The orbitofrontal cortex: reward, emotion and depression (2020) · cites this paper as Mayberg, 2003
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- Authors
- Mayberg, H. S.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Mayberg, Helen S.
- ORCID
- Mayberg, Helen S.
- Venue
- Neuroimaging Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 13
- Issue
- 4
- Pages
- 805-815
- ISSN
- 1052-5149 (ISSN-L)
- OpenAlex
- W1967087306
- Cited by
- 255
- References
- 86
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 9 · 2020: 6 · 2019: 5 · 2018: 11 · 2017: 11 · 2016: 9 · 2015: 16 · 2014: 11 · 2013: 11 · 2012: 17
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroimaging Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- depression, positron emission tomography, regional glucose metabolism, brain function, neural systems, depression subtypes, treatment response, multivariate analysis
- MeSH terms
- Antidepressive Agents, Brain, Depression, Humans, Predictive Value of Tests, Syndrome, Time Factors, Tomography, Emission-Computed, Biomarkers, Cognitive Behavioral Therapy
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