Relapse in anorexia nervosa: a survival analysis
Abstract
Background. Knowledge about factors that predict relapse in anorexia nervosa (AN) is needed for the development of effective relapse prevention treatments and may also advance understanding of the psychopathology of AN. The aim of the present study was to examine the rate, timing and prediction of relapse in AN following weight restoration in a specialized in-patient treatment programme. Method. Fifty-one consecutive first-admission AN patients who were weight-restored following in-patient treatment participated in the study. Follow-up assessments were conducted a median of 15 months post-discharge. Relapse of AN was defined as a body mass index <17·5 for 3 consecutive months. Data were analysed using Kaplan–Meier survival analysis and Cox regression. Results. The overall rate of relapse was 35% and the mean survival time was 18 months. The highest risk period was from 6 to 17 months after discharge. Several significant predictors of relapse were identified: a history of suicide attempt; previous specialized treatment for an eating disorder; severity of obsessive–compulsive symptoms at presentation; excessive exercise immediately after discharge; and residual concern about shape and weight at discharge. Conclusions. There continues to be a significant risk of relapse among AN patients who remain well for the first year post-discharge. Several variables were shown to be associated with an elevated risk of relapse. These findings have implications for the development of initial treatments and relapse prevention strategies for AN.
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The highest risk for relapse in clinical samples occurs within the first year after discharge.
“because the highest risk for relapse in clinical samples occurs within the first year after discharge (Carter et al., 2004, Herzog et al., 1999a).”
From Factors associated with recovery from anorexia nervosa (2013) · cites this paper as Carter et al., 2004
The highest risk for relapse from anorexia nervosa occurs within the first year after symptoms remit.
“We believe the likelihood of an earlier recovery event is low given evidence that the highest risk for relapse from AN occurs within the first year after symptoms remit (Carter et al., 2004, Herzog et al., 1999a).”
From Factors associated with recovery from anorexia nervosa (2013) · cites this paper as Carter et al., 2004
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BackgroundResultAttachment Insecurity, Personality, and Body Dissatisfaction in Eating Disorders
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Glasofer, D. R., Muratore, A. F., Attia, E., Wu, P., Wang, Y., Minkoff, H., Rufin, T., Walsh, B. T., & STEINGLASS, J. E. (2020) · Journal of Eating Disorders · doi:10.1186/s40337-020-00348-7 · Cited by 73 · see citing works
Measured physical activity in anorexia nervosa: Features and treatment outcome
Ghoch, M. E., Calugi, S., Pellegrini, M., Milanese, C., Busacchi, M., Battistini, N., Bernabè, J., & Grave, R. D. (2013) · International Journal of Eating Disorders · doi:10.1002/eat.22140 · Cited by 70 · see citing works
Exercise in the care of patients with anorexia nervosa: A systematic review of the literature
Moola, F. J., Gairdner, S. E., & Amara, C. E. (2013) · Mental Health and Physical Activity · doi:10.1016/j.mhpa.2013.04.002 · Cited by 69 · see citing works
Schlegl, S., Diedrich, A., Neumayr, C., Fumi, M., Naab, S., & Voderholzer, U. (2015) · European Eating Disorders Review · doi:10.1002/erv.2416 · Cited by 69 · see citing works
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McHugh, M. D. (2007) · International Journal of Eating Disorders · doi:10.1002/eat.20425 · Cited by 66 · see citing works
Understanding the reward system functioning in anorexia nervosa: Crucial role of physical activity
Giel, K. E., Kullmann, S., Preissl, H. T., Bischoff, S. C., Thiel, A., Schmidt, U. H., Zipfel, S., & Teufel, M. (2013) · Biological Psychology · doi:10.1016/j.biopsycho.2013.10.004 · Cited by 66 · see citing works
Overview of Treatment Modalities in Adolescent Anorexia Nervosa
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Drakes, D. H., Fawcett, E. J., Rose, J., Carter, J. C., & Fawcett, J. M. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.06.035 · Cited by 64 · see citing works
Self-citationPinto, A. M., Heinberg, L. J., Coughlin, J. W., Fava, J. L., & Guarda, Á. S. (2007) · Eating Behaviors · doi:10.1016/j.eatbeh.2007.07.001 · Cited by 64 · see citing works
The Anticipation and Perception of Affective Touch in Women with and Recovered from Anorexia Nervosa
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Predictors of excessive exercise in anorexia nervosa
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Self-citationCognitive behavioral therapy for anorexia nervosa: an update
Dalle Grave, R., El Ghoch, M., Sartirana, M., & Calugi, S. (2016) · Current Psychiatry Reports · doi:10.1007/s11920-015-0643-4 · Cited by 60 · see citing works
A risk profile of compulsive exercise in adolescents with an eating disorder: a systematic review
Fietz, M., Touyz, S. W., & Hay, P. (2014) · Advances in Eating Disorders · doi:10.1080/21662630.2014.894470 · Cited by 61 · see citing works
Berends, T., van Meijel, B., Nugteren, W., Deen, M. L., Danner, U. N., Hoek, H. W., & Elburg, A. A. V. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-1019-y · Cited by 61 · see citing works
Wildes, J. E., & Marcus, M. D. (2015) · Current Psychiatry Reports · doi:10.1007/s11920-015-0572-2 · Cited by 60 · see citing works
Gregertsen, E. C., Mandy, W., Kanakam, N., Armstrong, S., & Serpell, L. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.11.068 · Cited by 59 · see citing works
Vulnerable and Resilient Phenotypes in a Mouse Model of Anorexia Nervosa
Beeler, J. A., Mourra, D., Zanca, R. M., Kalmbach, A., Gellman, C., Klein, B., Ravenelle, R., Serrano, P. A., Moore, H. M., Rayport, S., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.06.030 · Cited by 59 · see citing works
Mindfulness Based Approaches to Obesity and Weight Loss Maintenance
Caldwell, K. L., Baime, M. J., & Wolever, R. Q. (2012) · Journal of Mental Health Counseling · doi:10.17744/mehc.34.3.t016616717774643 · Cited by 58 · see citing works
Mapping the evidence for the prevention and treatment of eating disorders in young people
Bailey, A. P., Parker, A. G., Colautti, L. A., Hart, L., Liu, P., & Hetrick, S. E. (2014) · Journal of Eating Disorders · doi:10.1186/2050-2974-2-5 · Cited by 59 · see citing works
Scharmer, C., Gorrell, S., Schaumberg, K., & Anderson, D. A. (2019) · Psychology of sport and exercise · doi:10.1016/j.psychsport.2019.101586 · Cited by 58 · see citing works
Aberrant network integrity of the inferior frontal cortex in women with anorexia nervosa
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Exercise interventions for women with anorexia nervosa: A review of the literature
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Higher-Calorie Refeeding in Anorexia Nervosa: 1-Year Outcomes From a Randomized Controlled Trial
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Body distortions in Anorexia Nervosa: Evidence for changed processing of multisensory bodily signals
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Beliefs about excessive exercise in eating disorders: The role of obsessions and compulsions
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Establishment of a chronic activity-based anorexia rat model
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Assessment of Physical Activity in Anorexia Nervosa and Treatment Outcome
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Does Percent Body Fat Predict Outcome in Anorexia Nervosa?
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Young, S., Rhodes, P., Touyz, S. W., & Hay, P. (2013) · Journal of Eating Disorders · doi:10.1186/2050-2974-1-16 · Cited by 53 · see citing works
Does Anorexia Nervosa Resemble an Addiction?
Barbarich-Marsteller, N. C., Foltin, R. W., & Walsh, B. T. (2011) · Current Drug Abuse Reviews · doi:10.2174/1874473711104030197 · Cited by 53 · see citing works
Young, S., Touyz, S. W., Meyer, C., Arcelus, J., Rhodes, P., Madden, S., Pike, K. M., Attia, E., Crosby, R. D., & Hay, P. (2018) · Journal of Eating Disorders · doi:10.1186/s40337-018-0188-0 · Cited by 53 · see citing works
- Authors
- CARTER, J. C., BLACKMORE, E., SUTANDAR-PINNOCK, K., & WOODSIDE, D. B.
- Affiliations
- University of Toronto (CA)
- ORCID
- WOODSIDE, D. B.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2004-04-21
- Volume
- 34
- Issue
- 4
- Pages
- 671-679
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W1995412283
- Cited by
- 389
- References
- 33
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 19 · 2023: 15 · 2022: 29 · 2021: 16 · 2020: 25 · 2019: 15 · 2018: 35 · 2017: 18 · 2016: 27 · 2015: 17 · 2014: 27 · 2013: 28 · 2012: 18
- FWCI
- 8.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- anorexia nervosa, relapse, recurrence prediction, weight restoration, in-patient treatment, relapse prevention, suicide attempts, obsessive-compulsive symptoms, excessive exercise, body image concern, eating disorder psychopathology
- MeSH terms
- Adaptation, Psychological, Adult, Anorexia Nervosa, Body Weight, Female, Follow-Up Studies, Humans, Patient Acceptance of Health Care, Recurrence, Risk Factors, Body Mass Index, Survival Analysis
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