Impaired inhibitory control is associated with higher-order repetitive behaviors in autism spectrum disorders
Open accessAbstract
Background: Impairments in executive cognitive control, including a reduced ability to inhibit prepotent responses, have been reported in autism spectrum disorders (ASD). These deficits may underlie patterns of repetitive behaviors associated with the disorder. Method: Eighteen individuals with ASD and 15 age- and IQ-matched healthy individuals performed an antisaccade task and a visually guided saccade control task, each with gap and overlap conditions. Measures of repetitive behaviors were obtained using the Autism Diagnostic Inventory – Revised (ADI-R) and examined in relation to neurocognitive task performance. Results: Individuals with an ASD showed increased rates of prosaccade errors (failures to inhibit prepotent responses) on the antisaccade task regardless of task condition (gap/overlap). Prosaccade error rates were associated with the level of higher-order (e.g. compulsions, preoccupations) but not sensorimotor repetitive behaviors in ASD. Conclusions: Neurocognitive disturbances in voluntary behavioral control suggest that alterations in frontostriatal systems contribute to higher-order repetitive behaviors in ASD.
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Some studies report typical attention disengagement in ASD.
“While evidence for impaired disengagement of attention in ASD exists across the lifespan, it should be noted that some studies report typical attention disengagement in ASD (Kawakubo, Maekawa, Itoh, Hashimoto, & Iwanami, 2004; Leekam, Lopez, & Moore, 2000; Mosconi et al., 2009).”
From Atypical attentional networks and the emergence of autism (2013) · cites this paper as Mosconi et al., 2009
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- Authors
- Mosconi, M. W., Kay, M., D'Cruz, A.-M., Seidenfeld, A., Guter, S., Stanford, L. D., & Sweeney, J. A.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Sweeney, J. A.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2009-01-21
- Volume
- 39
- Issue
- 9
- Pages
- 1559-1566
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- PMC
- PMC3145414
- OpenAlex
- W2135532814
- Cited by
- 222
- References
- 44
- Citations by year
- 2026: 7 · 2025: 2 · 2024: 12 · 2023: 13 · 2022: 13 · 2021: 19 · 2020: 20 · 2019: 20 · 2018: 20 · 2017: 19 · 2016: 12 · 2015: 14 · 2014: 13 · 2013: 16 · 2012: 11
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Autism Speaks (AS4853)
- National Institutes of Health
- University of Illinois at Chicago
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50HD055751, P01HD035469, HD35469, HD055751, U19HD035469)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, inhibitory control, executive function, repetitive behavior, compulsive behavior, preoccupation, antisaccade task, saccade control, prepotent response inhibition, frontostriatal circuits
- MeSH terms
- Adolescent, Adult, Attention, Autistic Disorder, Child, Compulsive Behavior, Corpus Striatum, Female, Humans, Inhibition, Psychological, Male, Middle Aged, Nerve Net, Orientation, Pattern Recognition, Visual, Personality Assessment, Psychomotor Performance, Reaction Time, Saccades, Stereotyped Behavior, Prefrontal Cortex, Asperger Syndrome, Young Adult
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