Cited by 234Autism Spectrum Disorder ResearchAdvanced Neuroimaging Techniques and ApplicationsGenetics and Neurodevelopmental Disorders

Fronto-striatal circuitry and inhibitory control in autism: Findings from diffusion tensor imaging tractography

Langen, Marieke, Leemans, Alexander, Johnston, Patrick, Ecker, Christine, Daly, Eileen, Murphy, Clodagh M., dell’Acqua, Flavio, Durston, Sarah +1 more·2012·Cortex

Abstract

Introduction Repetitive behaviour and inhibitory control deficits are core features of autism; and it has been suggested that they result from differences in the anatomy of striatum; and/or the 'connectivity' of subcortical regions to frontal cortex. There are few studies, however, that have measured the micro-structural organisation of white matter tracts connecting striatum and frontal cortex.Aims To investigate differences in bulk volume of striatum and micro-structural organisation of fronto-striatal white matter in people with autism; and their association with repetitive behaviour and inhibitory control.Methods We compared the bulk volume of striatum (caudate nucleus, putamen and nucleus accumbens) and white matter organisation of fronto-striatal tracts using (respectively) structural magnetic resonance imaging (sMRI) and tract specific diffusion tensor imaging (DTI) measures in 21 adults with autism and 22 controls. We also assessed performance on a cognitive inhibition (go/nogo) task.Results Bulk volume of striatal structures did not differ between groups. However, adults with autism had a significantly smaller total brain white matter volume, lower fractional anisotropy of white matter tracts connecting putamen to frontal cortical areas, higher mean diffusivity of white matter tracts connecting accumbens to frontal cortex and worse performance on the go/nogo task. Also, performance on the go/nogo task was significantly related to anatomical variation when both groups were combined; but not within the autism group alone.Conclusions These data suggest that autism may be associated with differences in the anatomy of fronto-striatal white matter tracts.

Integrity signals

Registry

Crossref · 10.1016/j.cortex.2011.05.018

Cites

93 of 93 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Langen, M., Leemans, A., Johnston, P., Ecker, C., Daly, E., Murphy, C. M., dell’Acqua, F., Durston, S., & Murphy, D. G. M.
Affiliations
  • King's College London (GB)
  • University Medical Center Utrecht (NL)
Corresponding author
Langen, Marieke
Venue
Cortex
Publisher
Elsevier BV
Published
2012-02
Volume
48
Issue
2
Pages
183-193
ISSN
0010-9452 (ISSN-L)
OpenAlex
W2118251677
Cited by
234
References
93
Citations by year
2026: 9 · 2025: 10 · 2024: 9 · 2023: 8 · 2022: 8 · 2021: 20 · 2020: 14 · 2019: 11 · 2018: 7 · 2017: 16 · 2016: 18 · 2015: 21 · 2014: 22 · 2013: 32 · 2012: 20
FWCI
13.47
Type
journal article
Language
en
Open access
closed
Locations
  • Cortex (publishedVersion)
  • PubMed (publishedVersion)
  • ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
  • National Institute for Health and Care Research (RP-PG-0606-1045, NF-SI-0510-10268)
  • Universitair Medisch Centrum Utrecht
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
autism spectrum disorder, frontostriatal circuits, inhibitory control, repetitive behavior, white matter microstructure, striatum, caudate nucleus, putamen, nucleus accumbens, fractional anisotropy, mean diffusivity, go/no-go task, white matter volume
MeSH terms
Adult, Autistic Disorder, Basal Ganglia, Corpus Striatum, Frontal Lobe, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Nerve Fibers, Nerve Net, Neuropsychological Tests, Social Behavior, International Classification of Diseases, Young Adult, Diffusion Tensor Imaging

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review