Fronto-striatal circuitry and inhibitory control in autism: Findings from diffusion tensor imaging tractography
Abstract
Introduction Repetitive behaviour and inhibitory control deficits are core features of autism; and it has been suggested that they result from differences in the anatomy of striatum; and/or the 'connectivity' of subcortical regions to frontal cortex. There are few studies, however, that have measured the micro-structural organisation of white matter tracts connecting striatum and frontal cortex.Aims To investigate differences in bulk volume of striatum and micro-structural organisation of fronto-striatal white matter in people with autism; and their association with repetitive behaviour and inhibitory control.Methods We compared the bulk volume of striatum (caudate nucleus, putamen and nucleus accumbens) and white matter organisation of fronto-striatal tracts using (respectively) structural magnetic resonance imaging (sMRI) and tract specific diffusion tensor imaging (DTI) measures in 21 adults with autism and 22 controls. We also assessed performance on a cognitive inhibition (go/nogo) task.Results Bulk volume of striatal structures did not differ between groups. However, adults with autism had a significantly smaller total brain white matter volume, lower fractional anisotropy of white matter tracts connecting putamen to frontal cortical areas, higher mean diffusivity of white matter tracts connecting accumbens to frontal cortex and worse performance on the go/nogo task. Also, performance on the go/nogo task was significantly related to anatomical variation when both groups were combined; but not within the autism group alone.Conclusions These data suggest that autism may be associated with differences in the anatomy of fronto-striatal white matter tracts.
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Fractional anisotropy is reduced in ASD compared to TD in fronto-striatal tracts.
“fronto-striatal tracts (Langen et al., 2012)”
From Behavioral, Perceptual, and Neural Alterations in Sensory and Multisensory Function in Autism Spectrum Disorder (2015) · cites this paper as Langen et al., 2012
Several recent imaging studies on resting-state functional connectivity and DTI confirm disruptive neural activation dynamics in ASD within the vmPFC-VS-amygdala circuitry.
“In fact, several recent imaging studies on resting-state functional connectivity and DTI confirm disruptive neural activation dynamics in ASD within the vmPFC–VS–amygdala circuitry [78-81].”
From Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications (2012) · cites this paper as [81]
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- Authors
- Langen, M., Leemans, A., Johnston, P., Ecker, C., Daly, E., Murphy, C. M., dell’Acqua, F., Durston, S., & Murphy, D. G. M.
- Affiliations
- King's College London (GB)
- University Medical Center Utrecht (NL)
- Corresponding author
- Langen, Marieke
- ORCID
- Venue
- Cortex
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 48
- Issue
- 2
- Pages
- 183-193
- ISSN
- 0010-9452 (ISSN-L)
- OpenAlex
- W2118251677
- Cited by
- 234
- References
- 93
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 9 · 2023: 8 · 2022: 8 · 2021: 20 · 2020: 14 · 2019: 11 · 2018: 7 · 2017: 16 · 2016: 18 · 2015: 21 · 2014: 22 · 2013: 32 · 2012: 20
- FWCI
- 13.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cortex (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- National Institute for Health and Care Research (RP-PG-0606-1045, NF-SI-0510-10268)
- Universitair Medisch Centrum Utrecht
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, frontostriatal circuits, inhibitory control, repetitive behavior, white matter microstructure, striatum, caudate nucleus, putamen, nucleus accumbens, fractional anisotropy, mean diffusivity, go/no-go task, white matter volume
- MeSH terms
- Adult, Autistic Disorder, Basal Ganglia, Corpus Striatum, Frontal Lobe, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Nerve Fibers, Nerve Net, Neuropsychological Tests, Social Behavior, International Classification of Diseases, Young Adult, Diffusion Tensor Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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