Childhood maltreatment is associated with increased body mass index and increased C-reactive protein levels in first-episode psychosis patients
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Background: The high incidence of the metabolic syndrome in patients with psychosis is mainly attributed to antipsychotic treatment. However, it is also possible that psychological stress plays a role, inducing a chronic inflammatory process that may predispose to the development of metabolic abnormalities. We investigated the association between childhood maltreatment and inflammatory and metabolic biomarkers in subjects with first-episode psychosis and healthy controls. Method: Body mass index (BMI), weight and waist circumference were measured in 95 first-episode psychosis patients and 97 healthy controls. Inflammatory and metabolic markers were measured in a subsample of 28 patients and 45 controls. In all the subjects we collected information on childhood maltreatment and recent stressors. Results: Patients with childhood maltreatment had higher BMI [25.0 (s.e.=0.6) kg/m 2] and C-reactive protein (CRP) levels [1.1 (s.e.=0.6) mg/dl] when compared with healthy controls [23.4 (s.e.=0.4) kg/m 2,p=0.030 and 0.2 (s.e.=0.1) mg/dl,p=0.009, respectively]. In contrast, patients without childhood maltreatment were not significantly different from healthy controls for either BMI [24.7 (s.e.=0.6) kg/m 2,p=0.07] or CRP levels [0.5 (s.e.=0.2) mg/dl,p=0.25]. After controlling for the effect of BMI, the difference in CRP levels across the three groups remained significant (F2,58=3.6,p=0.035), suggesting that the increase in inflammation was not driven by an increase in adipose tissue. Conclusions: Childhood maltreatment is associated with higher BMI, and increased CRP levels, in patients with a first-episode psychosis. Further studies need to confirm the mechanisms underlying the putative causal relationship between childhood maltreatment and higher BMI, and whether this is indeed mediated by increased inflammation.
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Most findings, but not all, suggest a robust correlation between ELS/CT and adult CRP levels.
“Most findings, but not all, suggest a robust correlation between ELS/CT and adult CRP levels (165, 166, 170, 199–202).”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [201]
The Results (Inflammatory markers: effect of group and childhood trauma) report higher adult hsCRP in first-episode psychosis patients with severe childhood sexual abuse than in patients without it. For childhood trauma more generally, the three-group comparison showed only a trend. The paper supports an association in this patient group, but not the broader claim that most findings show a robust correlation across populations. (LLM, conf=0.85)
Experimental — accuracy not yet measuredAn activated inflammatory system is relevant for patients with psychotic disorders, such as schizophrenia, by affecting physical health, brain structure, clinical outcome and the action of antipsychotics.
“an activated inflammatory system is also relevant for patients with psychotic disorders, such as schizophrenia, by affecting physical health, brain structure, clinical outcome and the action of antipsychotics”
From Why are depressed patients inflamed? A reflection on 20 years of research on depression, glucocorticoid resistance and inflammation (2017) · cites this paper as Hepgul et al., 2012
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- Authors
- Hepgul, N., Pariante, C. M., Dipasquale, S., DiForti, M., Taylor, H., Marques, T. R., Morgan, C., Dazzan, P., Murray, R. M., & Mondelli, V.
- Affiliations
- King's College London (GB)
- Corresponding author
- Mondelli, V.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2012-01-20
- Volume
- 42
- Issue
- 9
- Pages
- 1893-1901
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- PMC
- PMC4081598
- OpenAlex
- W2168638813
- Semantic Scholar
- 194871c8c144797db553c36f6948a40d07d4c771
- Cited by
- 112
- References
- 44
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 12 · 2022: 5 · 2021: 10 · 2020: 12 · 2019: 8 · 2018: 11 · 2017: 10 · 2016: 7 · 2015: 15 · 2014: 4 · 2013: 6 · 2012: 4
- FWCI
- 10.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Wellcome Trust (WT087417, 087417)
- National Institute for Health and Care Research (CL-2008-17-005)
- Academy of Medical Sciences (AMS-SGCL5-Mondelli)
- Medical Research Council (MR/J002739/1)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- child abuse, first-episode psychosis, body mass index, C-reactive protein, inflammation, metabolic syndrome, psychological stress, adiposity, waist circumference, antipsychotic-induced metabolic effects
- MeSH terms
- Adipose Tissue, Adolescent, Adult, C-Reactive Protein, Female, Humans, Inflammation, Male, Psychotic Disorders, Antipsychotic Agents, Body Mass Index, Case-Control Studies, Metabolic Syndrome, Adult Survivors of Child Abuse, Waist Circumference
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