Obesity and Type 2 Diabetes Risk in Midadult Life: The Role of Childhood Adversity
Abstract
OBJECTIVE. Child abuse has been associated with poorer physical health in adulthood, but less is known about childhood adversity more broadly, including neglect and family problems, or the pathways from adversity to adult disease. We have examined how different stressful emotional or neglectful childhood adversities are related to adiposity and glucose control in midadulthood, taking into account childhood factors, and whether the relationships are mediated by adult health behaviors and socioeconomic position. METHODS. This was a prospective longitudinal study of 9310 members of the 1958 British birth cohort who participated in a biomedical interview at 45 years of age. Primary outcomes consisted of continuous measures of BMI, waist circumference, and glycosylated hemoglobin at 45 years and categorical indicators: total obesity (BMI ≥ 30), central obesity (waist circumference: ≥102 cm for men and ≥88 cm for women), and glycosylated hemoglobin level of ≥6. RESULTS. The risk of obesity increased by 20% to 50% for several adversities (physical abuse, verbal abuse, witnessed abuse, humiliation, neglect, strict upbringing, physical punishment, conflict or tension, low parental aspirations or interest in education, hardly takes outings with parents, and father hardly reads to child). Adversities with the strongest associations with adiposity (eg, physical abuse) tended to be associated with glycosylated hemoglobin levels of ≥6, but in most cases associations were explained by adjustment for adulthood mediators such as adiposity. Effects of other adversities reflecting less severe emotional neglect and family environment were largely explained by childhood socioeconomic factors. CONCLUSIONS. Some childhood adversities increase the risk of obesity in adulthood and thereby increase the risk for type 2 diabetes. Research is needed to understand the interrelatedness of adversities, the social context of their occurrence, and trajectories from adversity to adult disease.
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Epidemiological and clinical studies link ELA to obesity, dyslipidemia, and type 2 diabetes.
“Interest in metabolic embedding of ELA stems from epidemiological [1, 69] and clinical [70] studies linking ELA to obesity, dyslipidemia, and type 2 diabetes, raising questions about possible causal pathways.”
From Biological embedding of childhood adversity: from physiological mechanisms to clinical implications (2017) · cites this paper as [69]
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- Authors
- Thomas, C., Hyppönen, E., & Power, C.
- Affiliations
- University College London (GB)
- Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, United Kingdom
- Corresponding author
- Thomas, Claudia
- Venue
- Pediatrics
- Publisher
- American Academy of Pediatrics (AAP)
- Published
- 2008-05-01
- Volume
- 121
- Issue
- 5
- Pages
- e1240-e1249
- ISSN
- 0031-4005 (ISSN-L)
- 1098-4275
- OpenAlex
- W2106821860
- Cited by
- 330
- References
- 59
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 9 · 2023: 12 · 2022: 15 · 2021: 19 · 2020: 18 · 2019: 29 · 2018: 14 · 2017: 32 · 2016: 19 · 2015: 28 · 2014: 17 · 2013: 26 · 2012: 22
- FWCI
- 22.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- PEDIATRICS (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institute for Health and Care Research (PHCS/C4/4/016)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- childhood adversity, childhood abuse, child neglect, type 2 diabetes risk, obesity, adiposity, abdominal obesity, HbA1c, glycemic control, physical abuse, verbal abuse, humiliation, parenting, family environment, socioeconomic position, 1958 British birth cohort
- MeSH terms
- Adolescent, Child, Child Abuse, Diabetes Mellitus, Type 2, Family Relations, Female, Glycated Hemoglobin, Humans, Male, Middle Aged, Obesity, Cohort Studies, Body Mass Index, Child of Impaired Parents, Parenting, Adult Survivors of Child Abuse
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