The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Transcranial direct current stimulation in the treatment of major depression: a meta-analysis
Abstract
Background: So far, no comprehensive answer has emerged to the question of whether transcranial direct current stimulation (tDCS) can make a clinically useful contribution to the treatment of major depression. We aim to present a systematic review and meta-analysis of tDCS in the treatment of depression. Method: Medline and Embase were searched for open-label and randomized controlled trials of tDCS in depression using the expressions (‘transcranial direct current stimulation’ or ‘tDCS’) and (‘depression’ or ‘depressed’). Study data were extracted with a standardized data sheet. For randomized controlled trials, effect size (Hedges' g) was calculated and the relationships between study variables and effect size explored using meta-regression. Results: A total of 108 citations were screened and 10 studies included in the systematic review. Six randomized controlled trials were included in the meta-analysis, with a cumulative sample of 96 active and 80 sham tDCS courses. Active tDCS was found to be more effective than sham tDCS for the reduction of depression severity (Hedges' g=0.743, 95% confidence interval 0.21–1.27), although study results differed more than expected by chance (Q=15.52, df=6, p=0.017, I2=61.35). Meta-regression did not reveal any significant correlations. Conclusions: Our study was limited by the small number of studies included, which often had small sample size. Future studies should use larger, if possible representative, health service patient samples, and optimized protocols to evaluate the efficacy of tDCS in the treatment of depression further.
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Cites
Operating characteristics of a rank correlation test for publication bias
Begg, C. B., & Mazumdar, M. (1994) · Biometrics · doi:10.2307/2533446 · Cited by 16,955
Nitsche, M. A., & Paulus, W. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00633.x · Cited by 5,656
Fixed-and random-effects models in meta-analysis.
Hedges, L. V., & Vevea, J. L. (1998) · Psychological Methods · doi:10.1037/1082-989x.3.4.486 · Cited by 2,977
Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans
Nitsche, M. A., & Paulus, W. (2001) · Neurology · doi:10.1212/wnl.57.10.1899 · Cited by 2,617
Treatment of depression with transcranial direct current stimulation (tDCS): A Review
Nitsche, M. A., Boggio, P. S., Fregni, F., & Pascual-Leone, A. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.03.038 · Cited by 498
Transcranial direct current stimulation for depression: 3-week, randomised, sham-controlled trial
Loo, C. K., Alonzo, A., Martin, D., Mitchell, P. B., Galvez, V., & Sachdev, P. (2012) · British Journal of Psychiatry · doi:10.1192/bjp.bp.111.097634 · Cited by 455
Self-citationBoosting focally-induced brain plasticity by dopamine
Kuo, M.-F., Paulus, W., & Nitsche, M. A. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm098 · Cited by 269 · cited 1×
“…has been repeatedly noted that the effects of tDCS are influenced substantially by neuromodulators including dopamine and acetylcholine (Nitsche et al. 2004, 2009; Kuo et al. 2007, 2008), a crucial question is whether the efficacy of tDCS is influenced by the current medication status of patients.”
BackgroundTranscranial direct current stimulation (tDCS) in unipolar vs. bipolar depressive disorder
Brunoni, A. R., Ferrucci, R., Bortolomasi, M., Vergari, M., Tadini, L., Boggio, P. S., Giacopuzzi, M., Barbieri, S., & Priori, A. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.09.010 · Cited by 226
Cited by
Cleare, A., Pariante, C., Young, A., Anderson, I., Christmas, D., Cowen, P., Dickens, C., Ferrier, I., Geddes, J., Gilbody, S., et al. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115581093 · Cited by 759
Horvath, J. C., Forte, J. D., & Carter, O. (2015) · Brain Stimulation · doi:10.1016/j.brs.2015.01.400 · Cited by 609
Brunoni, A. R., Moffa, A. H., Fregni, F., Palm, U., Padberg, F., Blumberger, D. M., Daskalakis, Z. J., Bennabi, D., Haffen, E., Alonzo, A., et al. (2016) · British Journal of Psychiatry · doi:10.1192/bjp.bp.115.164715 · Cited by 414
Self-citationMutz, J., Vipulananthan, V., Carter, B., Hurlemann, R., Fu, C. H. Y., & Young, A. H. (2019) · BMJ · doi:10.1136/bmj.l1079 · Cited by 427
Health, T. L. G. (2020) · The Lancet Global Health · doi:10.1016/s2214-109x(20)30432-0 · Cited by 417
“In their meta-analysis of six randomized controlled trials of tDCS use in depression, Kalu and colleagues found a significant reduction in the severity of depressive symptoms with active tDCS compared with sham tDCS.(16) However, they noted that many of the studies had small sample sizes, and they encouraged readers t…”
Shiozawa, P., Fregni, F., Benseñor, I. M., Lotufo, P. A., Berlim, M. T., Daskalakis, J. Z., Cordeiro, Q., & Brunoni, A. R. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000418 · Cited by 282
Stagg, C. J., Lin, R. L., Mezue, M., Segerdahl, A., Kong, Y., Xie, J., & Tracey, I. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3887-12.2013 · Cited by 279
Concurrent cognitive control training augments the antidepressant efficacy of tDCS: A pilot study
Segrave, R. A., Arnold, S., Hoy, K., & Fitzgerald, P. B. (2014) · Brain Stimulation · doi:10.1016/j.brs.2013.12.008 · Cited by 244
Meron, D., Hedger, N., Garner, M., & Baldwin, D. S. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.07.012 · Cited by 220
Brain-Derived Neurotrophic Factor and Major Depressive Disorder: Evidence from Meta-Analyses
Kishi, T., Yoshimura, R., Ikuta, T., & Iwata, N. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00308 · Cited by 213
Imaging human brain networks to improve the clinical efficacy of non-invasive brain stimulation
Sale, M. V., Mattingley, J. B., Zalesky, A., & Cocchi, L. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.09.010 · Cited by 145
Transcranial direct current stimulation in psychiatric disorders
Tortella, G. (2015) · World Journal of Psychiatry · doi:10.5498/wjp.v5.i1.88 · Cited by 154
Salehinejad, M. A., Wischnewski, M., Nejati, V., Vicario, C. M., & Nitsche, M. A. (2019) · PLOS ONE · doi:10.1371/journal.pone.0215095 · Cited by 126
Oliveira, J. F., Zanão, T. A., Valiengo, L., Lotufo, P. A., Benseñor, I. M., Fregni, F., & Brunoni, A. R. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.01.023 · Cited by 138
Ironside, M., O’Shea, J., Cowen, P. J., & Harmer, C. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.012 · Cited by 125
Millan, M. J., Goodwin, G. M., Meyer-Lindenberg, A., & Ove Ögren, S. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.01.016 · Cited by 132
Hits and misses: leveraging tDCS to advance cognitive research
Berryhill, M. E. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.00800 · Cited by 128
Improving interference control in ADHD patients with transcranial direct current stimulation (tDCS)
Breitling, C., Zaehle, T., Dannhauer, M., Bonath, B., Tegelbeckers, J., Flechtner, H.-H., & Krauel, K. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00072 · Cited by 98
Brunoni, A. R., Zanao, T. A., Vanderhasselt, M.-A., Valiengo, L., de Oliveira, J. F., Boggio, P. S., Lotufo, P. A., Benseñor, I. M., & Fregni, F. (2014) · Neuromodulation: Technology at the Neural Interface · doi:10.1111/ner.12080 · Cited by 85
Cook (2014) · doi:10.1016/j.nec.2013.10.002 · Cited by 69
Meyer, B., Mann, C., Götz, M., Gerlicher, A., Saase, V., Yuen, K. S. L., Aedo-Jury, F., Gonzalez-Escamilla, G., Stroh, A., & Kalisch, R. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.3128-18.2019 · Cited by 43
They are laughing at me: Cerebral mediation of cognitive biases in social anxiety
Kreifelts, B., Brück, C., Ritter, J., Ethofer, T., Domin, M., Lotze, M., Jacob, H., Schlipf, S., & Wildgruber, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099815 · Cited by 31
“Moreover, a recent meta-analysis indicated a positive effect of left DLPFC tDCS on symptom reduction in depression [56].”
BackgroundTranscranial direct current stimulation: considerations for research in adolescent depression
Lee, J. C., Lewis, C. P., Daskalakis, Z. J., & Croarkin, P. E. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00091 · Cited by 22
Ramasubramanian, V., Mathumathi, S., Rajendhiran, G., Bijulakshmi, P., & Kannan, M. (2022) · Industrial Psychiatry Journal · doi:10.4103/ipj.ipj_217_20 · Cited by 10
Metadata
- Authors
- Kalu, U. G., Sexton, C. E., Loo, C. K., & Ebmeier, K. P.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2012-01-12
- Volume
- 42
- Issue
- 9
- Pages
- 1791-1800
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2023484210
- Cited by
- 299
- References
- 8
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- closed
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