Cited by 137Personality Disorders and PsychopathologySuicide and Self-Harm StudiesBipolar Disorder and Treatment

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Predictors of suicide attempts in patients with borderline personality disorder over 16 years of prospective follow-up

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Wedig, M. M., Silverman, M. H., Frankenburg, F. R., Reich, D. Bradford, Fitzmaurice, G., Zanarini, M. C.·2012·Psychological Medicine

DOI 10.1017/s0033291712000517PMC PMC3600404

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Abstract

BACKGROUND: It is clinically important to understand the factors that increase the likelihood of the frequent and recurrent suicide attempts seen in those with borderline personality disorder (BPD). Although several studies have examined this subject in a cross-sectional manner, the aim of this study was to determine the most clinically relevant baseline and time-varying predictors of suicide attempts over 16 years of prospective follow-up among patients with BPD. METHOD: Two-hundred and ninety in-patients meeting Revised Diagnostic Interview for Borderlines (DIB-R) and DSM-III-R criteria for BPD were assessed during their index admission using a series of semistructured interviews and self-report measures. These subjects were then reassessed using the same instruments every 2 years. The generalized estimating equations (GEE) approach was used to model the odds of suicide attempts in longitudinal analyses, controlling for assessment period, yielding an odds ratio (OR) and 95% confidence interval (CI) for each predictor. RESULTS: Nineteen variables were found to be significant bivariate predictors of suicide attempts. Eight of these, seven of which were time-varying, remained significant in multivariate analyses: diagnosis of major depressive disorder (MDD), substance use disorder (SUD), post-traumatic stress disorder (PTSD), presence of self-harm, adult sexual assault, having a caretaker who has completed suicide, affective instability, and more severe dissociation. CONCLUSIONS: The results of this study suggest that prediction of suicide attempts among borderline patients is complex, involving co-occurring disorders, co-occurring symptoms of BPD (self-harm, affective reactivity and dissociation), adult adversity, and a family history of completed suicide.

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Authors: Wedig, M. M., Silverman, M. H., Frankenburg, F. R., Reich, D. B., Fitzmaurice, G., & Zanarini, M. C.
Affiliations: Harvard University (US)
McLean Hospital (US)
Boston University (US)
Corresponding author: Wedig, M. M.
ORCID: Reich, D. Bradford
Fitzmaurice, G.
Zanarini, M. C.
Venue: Psychological Medicine
Publisher: Cambridge University Press (CUP)
Published: 2012-03-22
Volume: 42
Issue: 11
Pages: 2395-2404
ISSN: 0033-2917 (ISSN-L)
1469-8978
DOI: 10.1017/s0033291712000517
PMC: PMC3600404
OpenAlex: W2051744096
Cited by: 137
References: 52
Citations by year: 2026: 8 · 2025: 5 · 2024: 10 · 2023: 13 · 2022: 8 · 2021: 18 · 2020: 9 · 2019: 10 · 2018: 6 · 2017: 6 · 2016: 13 · 2015: 9 · 2014: 13 · 2013: 7 · 2012: 1
FWCI: 10.79
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.cambridge.org/core/terms (unspecified)
Locations: Psychological Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: McLean Hospital
National Institute of Mental Health (MH-62169, R29MH047588, R01MH062169, MH-47588)
Topics: Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Keywords: borderline personality disorder, suicide attempts, major depressive disorder, substance use disorders, post-traumatic stress disorder, self-harm, adult sexual assault, family history of suicide, neuroticism, dissociation, comorbidities
MeSH terms: Adult, Mental Disorders, Borderline Personality Disorder, Female, Humans, Longitudinal Studies, Male, Risk Factors, Suicide, Attempted, Comorbidity, Young Adult

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Predictors of suicide attempts in patients with borderline personality disorder over 16 years of prospective follow-up

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