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Cited by 66Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

Acoustic startle reflex in schizophrenia patients and their first‐degree relatives: Evidence of normal emotional modulation

Curtis, Clayton E., Lebow, Boyd, Lake, David S., Katsanis, Joanna, Iacono, William G.·1999·Psychophysiology
DOI 10.1017/s0048577299980757
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Abstract

We investigated emotional disturbances in 36 schizophrenia patients, 48 of their first‐degree relatives, and 56 controls to determine if abnormal affective startle modulation could be associated with genetic risk for schizophrenia. Both patients and relatives had a pattern of startle modulation indistinguishable from controls, with potentiated startle amplitude while viewing negative valence slides and attenuation while viewing positive slides. Patients with flat affect did not differ from those without in startle modulation or slide ratings. The patients and their relatives had lower pleasantness ratings of positive slides and the patients had higher pleasantness ratings of the negative slides than controls. The startle paradigm may not be useful for identifying individuals with a genetic liability for schizophrenia. The results suggest that low‐level defensive and appetitive behaviors are unaffected in schizophrenia.

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  • Psychophysiological studies of patients with schizophrenia indicate comparable or more exaggerated facial responsivity to positive and negative stimuli, assessed via facial electromyography, skin conductance, and affective modulation of the startle eyeblink response.

    “psychophysiological studies of patients with schizophrenia indicate comparable or more exaggerated facial responsivity to positive and negative stimuli, assessed via facial electromyography [397,398], skin conductance [399,400], and affective modulation of the startle eyeblink response [401,402].”

    From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [401]

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Authors
Curtis, C. E., Lebow, B., Lake, D. S., Katsanis, J., & Iacono, W. G.
Affiliations
  • University of Minnesota (US)
  • University of Arizona (US)
Corresponding author
Iacono, William G.
ORCID
Venue
Psychophysiology
Publisher
Wiley
Published
1999-07
Volume
36
Issue
4
Pages
469-475
ISSN
  • 0048-5772 (ISSN-L)
  • 1469-8986
DOI
10.1017/s0048577299980757
OpenAlex
W2082771231
Cited by
66
References
31
Citations by year
2025: 1 · 2022: 2 · 2019: 1 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 4 · 2013: 1 · 2012: 4
FWCI
1.43
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1357 d)
Locations
  • Psychophysiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01mh049738-04)
  • National Institute of Mental Health (MH 17069, T32MH017069, MH 49738)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
acoustic startle response, schizophrenia, first-degree relatives, emotional valence, flat affect, genetic risk, startle potentiation, defensive behavior
MeSH terms
Adult, Affective Symptoms, Analysis of Variance, Female, Humans, Male, Middle Aged, Nuclear Family, Schizophrenia, Reflex, Startle, Chi-Square Distribution, Case-Control Studies, Genetic Predisposition to Disease

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