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Cited by 328Child Abuse and TraumaChild and Adolescent Psychosocial and Emotional DevelopmentPsychopathy, Forensic Psychiatry, Sexual Offending

The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.

Nature × nurture: Genetic vulnerabilities interact with physical maltreatment to promote conduct problems

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JAFFEE, SARA R., CASPI, AVSHALOM, MOFFITT, TERRIE E., DODGE, KENNETH A., RUTTER, MICHAEL, TAYLOR, ALAN, TULLY, LUCY A.·2005·Development and Psychopathology
DOI 10.1017/s0954579405050042PMC PMC2768347
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Abstract

Maltreatment places children at risk for psychiatric morbidity, especially conduct problems. However, not all maltreated children develop conduct problems. We tested whether the effect of physical maltreatment on risk for conduct problems was strongest among those who were at high genetic risk for these problems using data from the E-risk Study, a representative cohort of 1,116 5-year-old British twin pairs and their families. Children's conduct problems were ascertained via parent and teacher interviews. Physical maltreatment was ascertained via parent report. Children's genetic risk for conduct problems was estimated as a function of their co-twin's conduct disorder status and the pair's zygosity. The effect of maltreatment on risk for conduct problems was strongest among those at high genetic risk. The experience of maltreatment was associated with an increase of 2% in the probability of a conduct disorder diagnosis among children at low genetic risk for conduct disorder but an increase of 24% among children at high genetic risk. Prediction of behavioral pathology can attain greater accuracy if both pathogenic environments and genetic risk are ascertained. Certain genotypes may promote resistance to trauma. Physically maltreated children whose first-degree relatives engage in antisocial behavior warrant priority for therapeutic intervention. We are grateful to the Study mothers and fathers, the twins, and the twins' teachers for their participation. Our thanks to Robert Plomin for his contributions; to Thomas Achenbach for generous permission to adapt the CBCL; to Tom Price for comments on earlier drafts of this manuscript; to Hallmark Cards for their support; and to members of the E-Risk team for their dedication, hard work, and insights. The E-Risk Study is funded by Medical Research Council Grant G9806489. Terrie Moffitt is a Royal Society–Wolfson Research Merit Award holder.

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  1. Widom, C. S. , & Maxfield, M. G. (2001).An update on the “cycle of violence”(NCJ 184894).Washington, DC:National Institute of Justice. · DOI
  2. American Psychiatric Association .(1994).Diagnostic and statistical manual of mental disorders(4th ed.).Washington, DC:Author.
  3. Jaffee, S. R. (in press).Family violence and parent psychopathology: Implications forchildren's socioemotional development and resilience. In S. Goldstein & R. Brooks (Eds.),Handbook of resilience in children.New York:Kluwer.
  4. Potter, L. B. , & Mercy, J. A. (1997).Public health perspective on interpersonal violence among youths inthe United States.In D. M. Stoff , J. Breiling , & J. D. Maser (Eds.),Handbook of antisocial behavior (pp.3–11).New York:Wiley.

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Metadata

Authors
JAFFEE, S. R., CASPI, A., MOFFITT, T. E., DODGE, K. A., RUTTER, M., TAYLOR, A., & TULLY, L. A.
Affiliations
  • King's College London (GB)
  • University of Wisconsin–Madison (US)
  • Duke University (US)
ORCID
Venue
Development and Psychopathology
Publisher
Cambridge University Press (CUP)
Published
2005-03
Volume
17
Issue
1
Pages
67-84
ISSN
  • 0954-5794 (ISSN-L)
  • 1469-2198
DOI
10.1017/s0954579405050042
PMC
PMC2768347
OpenAlex
W2110622864
Cited by
328
References
77
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 5 · 2020: 6 · 2019: 10 · 2018: 11 · 2017: 13 · 2016: 25 · 2015: 18 · 2014: 22 · 2013: 17 · 2012: 17
FWCI
30.86
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified, 37 d)
Locations
  • Development and Psychopathology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
  • Economic and Social Research Council (L330 25 3002)
  • National Institute on Drug Abuse (K05DA015226)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Keywords
physical abuse, child abuse, conduct problems, conduct disorder, genetic risk, gene-environment interaction, twin pairs, zygosity, antisocial behavior, early childhood
MeSH terms
Adolescent, Antisocial Personality Disorder, Child, Child Abuse, Child Behavior Disorders, Child Development, Diseases in Twins, Female, Genotype, Humans, Life Change Events, Longitudinal Studies, Male, Risk Factors, Social Environment, Comorbidity, Conduct Disorder, Genetic Predisposition to Disease

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