The DOI matches its Crossref record; 220 of the 220 references it cites were found in a registry or an index.
Exposure to early adversity: Points of cross-species translation that can lead to improved understanding of depression
Open accessAbstract
The relationship between developmental exposure to adversity and affective disorders is reviewed. Adversity discussed herein includes physical and sexual abuse, neglect, or loss of a caregiver in humans. While these stressors can occur at any point during development, the unique temporal relationship to specific depressive symptoms was the focus of discussion. Further influences of stress exposure during sensitive periods can vary by gender and duration of abuse as well. Data from animal studies are presented to provide greater translational and causal understanding of how sensitive periods, different types of psychosocial stressors, and sex interact to produce depressive-like behaviors. Findings from maternal separation, isolation rearing, chronic variable stress, and peer–peer rearing paradigms clarify interpretation about how various depressive behaviors are influenced by age of exposure. Depressive behaviors are broken down into the following categories: mood and affect, anhedonia, energy, working memory, sleep–wake, appetite changes, suicide, and general malaise. Cross-species evidence from humans, nonhuman primates, rats, and mice within each of these categories is discussed. In conclusion, sensitive periods for affective-related behaviors (anxiety, mood, and controllability) occur earlier in life, while other aspects of depression are associated with adversity later during adolescence.
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“Our findings support the proposition from multiple domains of analysis that exposure to stress early in life had a dose-dependent effect on increasing the risk of later psychopathology, particularly in the domain of internalizing behaviours (Andersen 2015).”
From The effects of paternal depression on child and adolescent outcomes: A systematic review (2016) · cites this paper as Andersen 2015
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Dai, Z., Luo, Y., Tan, J., Hu, L., & Dai, Q. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2026.1733077
Metadata
- Authors
- Andersen, S. L.
- Affiliations
- Harvard University (US)
- Corresponding author
- Andersen, Susan L.
- ORCID
- Andersen, Susan L.
- Venue
- Development and Psychopathology
- Publisher
- Cambridge University Press (CUP)
- Published
- 2015-05
- Volume
- 27
- Issue
- 2
- Pages
- 477-491
- ISSN
- 0954-5794 (ISSN-L)
- 1469-2198
- PMC
- PMC5237807
- OpenAlex
- W2271686560
- Cited by
- 116
- References
- 217
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 6 · 2023: 10 · 2022: 10 · 2021: 14 · 2020: 17 · 2019: 10 · 2018: 7 · 2017: 17 · 2016: 12
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Development and Psychopathology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH091114)
- National Institute on Drug Abuse (R01 DA-026485-04, R01DA026485, R01DA015403, R01 DA-015403-10)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- childhood adversity, developmental stress, depression, sensitive period, cross-species translation, psychosocial stressors, maternal separation, isolation rearing, chronic variable stress, peer rearing, sex differences, anhedonia, appetite changes, suicide, working memory, mood disorders, abuse and neglect, caregiver loss
- MeSH terms
- Animals, Anxiety, Depression, Depressive Disorder, Disease Models, Animal, Female, Humans, Male, Maternal Deprivation, Mice, Rats
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