Cited by 116Stress Responses and CortisolChild Abuse and TraumaChild and Adolescent Psychosocial and Emotional Development

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Exposure to early adversity: Points of cross-species translation that can lead to improved understanding of depression

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Andersen, Susan L.·2015·Development and Psychopathology

DOI 10.1017/s0954579415000103PMC PMC5237807

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Abstract

The relationship between developmental exposure to adversity and affective disorders is reviewed. Adversity discussed herein includes physical and sexual abuse, neglect, or loss of a caregiver in humans. While these stressors can occur at any point during development, the unique temporal relationship to specific depressive symptoms was the focus of discussion. Further influences of stress exposure during sensitive periods can vary by gender and duration of abuse as well. Data from animal studies are presented to provide greater translational and causal understanding of how sensitive periods, different types of psychosocial stressors, and sex interact to produce depressive-like behaviors. Findings from maternal separation, isolation rearing, chronic variable stress, and peer–peer rearing paradigms clarify interpretation about how various depressive behaviors are influenced by age of exposure. Depressive behaviors are broken down into the following categories: mood and affect, anhedonia, energy, working memory, sleep–wake, appetite changes, suicide, and general malaise. Cross-species evidence from humans, nonhuman primates, rats, and mice within each of these categories is discussed. In conclusion, sensitive periods for affective-related behaviors (anxiety, mood, and controllability) occur earlier in life, while other aspects of depression are associated with adversity later during adolescence.

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Authors: Andersen, S. L.
Affiliations: Harvard University (US)
Corresponding author: Andersen, Susan L.
ORCID: Andersen, Susan L.
Venue: Development and Psychopathology
Publisher: Cambridge University Press (CUP)
Published: 2015-05
Volume: 27
Issue: 2
Pages: 477-491
ISSN: 0954-5794 (ISSN-L)
1469-2198
DOI: 10.1017/s0954579415000103
PMC: PMC5237807
OpenAlex: W2271686560
Cited by: 116
References: 217
Citations by year: 2026: 2 · 2025: 10 · 2024: 6 · 2023: 10 · 2022: 10 · 2021: 14 · 2020: 17 · 2019: 10 · 2018: 7 · 2017: 17 · 2016: 12
FWCI: 0.97
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified, 5 d)
Locations: Development and Psychopathology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01MH091114)
National Institute on Drug Abuse (R01 DA-026485-04, R01DA026485, R01DA015403, R01 DA-015403-10)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords: childhood adversity, developmental stress, depression, sensitive period, cross-species translation, psychosocial stressors, maternal separation, isolation rearing, chronic variable stress, peer rearing, sex differences, anhedonia, appetite changes, suicide, working memory, mood disorders, abuse and neglect, caregiver loss
MeSH terms: Animals, Anxiety, Depression, Depressive Disorder, Disease Models, Animal, Female, Humans, Male, Maternal Deprivation, Mice, Rats

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Exposure to early adversity: Points of cross-species translation that can lead to improved understanding of depression

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