DWI predicts future progression to Alzheimer disease in amnestic mild cognitive impairment
Open accessAbstract
The authors assessed whether measures of hippocampal water diffusivity at baseline can predict future progression to Alzheimer disease (AD) in amnestic mild cognitive impairment (aMCI). Higher baseline hippocampal diffusivity was associated with a greater risk of progression to AD in aMCI (p = 0.002). Magnetic resonance diffusion-weighted imaging may help identify patients with aMCI who will progress to AD as well as or better than structural MRI measures of hippocampal atrophy.
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In some studies, hippocampal diffusivity demonstrated higher diagnostic and prognostic accuracy than hippocampal volume.
“In some studies, hippocampal diffusivity even demonstrated a higher diagnostic and prognostic accuracy than hippocampal volume (Fellgiebel et al., 2006, Kantarci et al., 2005, Müller et al., 2007).”
From Mean diffusivity in cortical gray matter in Alzheimer's disease: The importance of partial volume correction (2018) · cites this paper as Kantarci et al., 2005
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“The microstructure changes of patients with mild cognitive impairment have also been identified in the hippocampus using dMRI (Kantarci et al., 2005; Veale et al., 2021).”
Method
- Authors
- Kantarci, K., Petersen, R. C., Boeve, B. F., Knopman, D. S., Weigand, S. D., O’Brien, P. C., Shiung, M. M., Smith, G. E., Ivnik, R. J., Tangalos, E. G., & Jack, C. R.
- Affiliations
- Mayo Clinic (US)
- Venue
- Neurology
- Published
- 2005-03-08
- Volume
- 64
- Issue
- 5
- Pages
- 902-904
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC2771335
- OpenAlex
- W2024786968
- Cited by
- 251
- References
- 1
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 11 · 2023: 11 · 2022: 8 · 2021: 8 · 2020: 8 · 2019: 5 · 2018: 8 · 2017: 11 · 2016: 9 · 2015: 17 · 2014: 11 · 2013: 14 · 2012: 18
- FWCI
- 10.47
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG-06786, AG 16574, U01AG006786, R01AG011378, AG-11378, R37AG011378, P50AG016574)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- diffusion-weighted imaging, amnestic mild cognitive impairment, risk prediction, hippocampal atrophy, diffusion MRI
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Amnesia, Body Water, Cognition Disorders, Diffusion, Female, Hippocampus, Humans, Male, Neuropsychological Tests, Predictive Value of Tests, Prognosis, Biomarkers, Multivariate Analysis, Disease Progression, Diffusion Magnetic Resonance Imaging, Early Diagnosis
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