Ultrastructural hippocampal and white matter alterations in mild cognitive impairment: a diffusion tensor imaging study
Abstract
Mild cognitive impairment (MCI) is considered to be a transitional stage between normal aging and dementia. In Alzheimer's disease (AD), white matter structural pathology is due to Wallerian degeneration and central angiopathy. However, in MCI patients, the presence and extent of white matter alterations as a possible correlate of impaired memory function and as predictor of subsequent progression to AD is not clarified yet. Diffusion tensor imaging (DTI) reveals the ultrastructural integrity of cerebral white matter tracts. Therefore, it could detect pathological processes that modify tissue integrity in patients with MCI. In our prospective study, conventional and diffusion tensor MR scans were obtained from 14 patients with MCI, 19 patients with AD, and 10 healthy controls. Mean diffusivity (MD) and fractional anisotropy (FA) were measured in temporal, frontal, parietal and occipital white matter regions as well as in the corpus callosum (genu and splenium) and the hippocampus. MCI patients showed higher MD values in the left centrum semiovale (p = 0.013; right: p = 0.026), in the left temporal (p = 0.006), the right temporal (p = 0.014) and the left hippocampal (p = 0.002) region as compared to the control group. FA values of MCI patients and controls did not differ significantly in any region. Compared to controls, AD patients had increased MD values in the left centrum semiovale (p = 0.012), the left parietal (p = 0.001), the right parietal (p = 0.028), the left tempora…
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Previous studies reported increases of hippocampal mean diffusivity and whole brain gray matter mean diffusivity in subjects with mild cognitive impairment compared to healthy controls.
“Previous studies on GM MD in AD reported increases of hippocampal MD and whole brain GM MD in subjects with mild cognitive impairment (MCI) as compared to healthy controls (Cherubini et al., 2010, Eustache et al., 2016, Fellgiebel et al., 2004, Müller et al., 2005, Scola et al., 2010)”
From Mean diffusivity in cortical gray matter in Alzheimer's disease: The importance of partial volume correction (2018) · cites this paper as Fellgiebel et al., 2004
The MD measurements in grey matter regions are in good agreement with previous studies that have detected elevated values in the brains of AD patients and in mouse models exhibiting amyloid pathology at late stages of progression.
“The MD measurements in grey matter regions are in good agreement with previous studies that have detected elevated values in the brains of AD patients (Fellgiebel et al., 2004, Kantarci et al., 2001, Rose et al., 2008) and in mouse models exhibiting amyloid pathology at late stages of progression (Sun et al., 2005).”
From In vivo imaging of tau pathology using multi-parametric quantitative MRI (2015) · cites this paper as Fellgiebel et al., 2004
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- Authors
- Fellgiebel, A., Wille, P., Müller, M. J., Winterer, G., Scheurich, A., Vucurevic, G., Schmidt, L. G., & Stoeter, P.
- Affiliations
- Johannes Gutenberg University Mainz (DE)
- Venue
- Dementia and Geriatric Cognitive Disorders
- Publisher
- S. Karger AG
- Published
- 2004
- Volume
- 18
- Issue
- 1
- Pages
- 101-108
- ISSN
- 1420-8008 (ISSN-L)
- 1421-9824
- OpenAlex
- W1994206031
- Cited by
- 298
- References
- 7
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 4 · 2020: 5 · 2019: 10 · 2018: 14 · 2017: 11 · 2016: 8 · 2015: 15 · 2014: 8 · 2013: 28 · 2012: 25
- FWCI
- 11.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dementia and Geriatric Cognitive Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- mild cognitive impairment, Alzheimer's disease, white matter changes, hippocampus, mean diffusivity, fractional anisotropy, diffusion tensor imaging, centrum semiovale, corpus callosum, Wallerian degeneration, dementia progression, white matter microstructure, memory impairment, brain ultrastructure, temporal lobe
- MeSH terms
- Aged, Alzheimer Disease, Brain, Cognition Disorders, Female, Hippocampus, Humans, Hypercholesterolemia, Hypertension, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Psychiatric Status Rating Scales, Risk Factors, Anisotropy
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