The DOI matches its Crossref record; 140 of the 140 references it cites were found in a registry or an index.
SNRIs: The Pharmacology, Clinical Efficacy, and Tolerability in Comparison with Other Classes of Antidepressants
Abstract
The class of serotonin and norepinephrine reuptake inhibitors (SNRIs) now comprises three medications: venlafaxine, milnacipran, and duloxetine. These drugs block the reuptake of both serotonin (5-HT) and norepinephrine with differing selectivity. Whereas milnacipran blocks 5-HT and norepinephrine reuptake with equal affinity, duloxetine has a 10-fold selectivity for 5-HT and venlafaxine a 30-fold selectivity for 5-HT. All three SNRIs are efficacious in treating a variety of anxiety disorders. There is no evidence for major differences between SNRIs and SSRIs in their efficacy in treating anxiety disorders. In contrast to SSRIs, which are generally ineffective in treating chronic pain, all three SNRIs seem to be helpful in relieving chronic pain associated with and independent of depression. Tolerability of an SNRI at therapeutic doses varies within the class. Although no direct comparative data are available, venlafaxine seems to be the least well-tolerated, combining serotonergic adverse effects (nausea, sexual dysfunction, withdrawal problems) with a dose-dependent cardiovascular phenomenon, principally hypertension. Duloxetine and milnacipran appear better tolerated and essentially devoid of cardiovascular toxicity.
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Cites
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Cited by
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Self-citationSide effects of antidepressants during long-term use in a naturalistic setting
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Metadata
- Authors
- Stahl, S. M., Grady, M. M., Moret, C., & Briley, M.
- Venue
- CNS Spectrums
- Publisher
- Cambridge University Press (CUP)
- Published
- 2005-09
- Volume
- 10
- Issue
- 9
- Pages
- 732-747
- ISSN
- 1092-8529 (ISSN-L)
- 2165-6509
- OpenAlex
- W1867335213
- Cited by
- 458
- References
- 140
- FWCI
- 14.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Stahl, S. M., Grady, M. M., Moret, C., & Briley, M. (2005). SNRIs: The Pharmacology, Clinical Efficacy, and Tolerability in Comparison with Other Classes of Antidepressants. CNS Spectrums. https://doi.org/10.1017/s1092852900019726
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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