Effects of antipsychotics, antidepressants and mood stabilizers on risk for physical diseases in people with schizophrenia, depression and bipolar disorder
Open accessAbstract
People with severe mental illness have a considerably shorter lifespan than the general population. This excess mortality is mainly due to physical illness. Next to mental illness-related factors, unhealthy lifestyle, and disparities in health care access and utilization, psychotropic medications can contribute to the risk of physical morbidity and mortality. We systematically reviewed the effects of antipsychotics, antidepressants and mood stabilizers on physical health outcomes in people with schizophrenia, depression and bipolar disorder. Updating and expanding our prior systematic review published in this journal, we searched MEDLINE (November 2009 - November 2014), combining the MeSH terms of major physical disease categories (and/or relevant diseases within these categories) with schizophrenia, major depressive disorder and bipolar disorder, and the three major psychotropic classes which received regulatory approval for these disorders, i.e., antipsychotics, antidepressants and mood stabilizers. We gave precedence to results from (systematic) reviews and meta-analyses wherever possible. Antipsychotics, and to a more restricted degree antidepressants and mood stabilizers, are associated with an increased risk for several physical diseases, including obesity, dyslipidemia, diabetes mellitus, thyroid disorders, hyponatremia; cardiovascular, respiratory tract, gastrointestinal, haematological, musculoskeletal and renal diseases, as well as movement and seizure disorders. Higher dosages, polypharmacy, and treatment of vulnerable (e.g., old or young) individuals are associated with greater absolute (elderly) and relative (youth) risk for most of these physical diseases. To what degree medication-specific and patient-specific risk factors interact, and how adverse outcomes can be minimized, allowing patients to derive maximum benefits from these medications, requires adequate clinical attention and further research.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Long-term antipsychotic use can have serious consequences including tardive dyskinesia, weight gain, metabolic syndrome, diabetes and cardiovascular complications.
“However, long-term antipsychotic use can have serious consequences including tardive dyskinesia, weight gain, metabolic syndrome, diabetes and cardiovascular complications.3”
From Stopping and switching antipsychotic drugs (2019) · cites this paper as [3]
Several factors contribute to the early and frequent development of cardiovascular disease in this population, including genetic vulnerability, metabolic adverse effects of antipsychotics, insufficient treatment of somatic comorbidity, and unhealthy lifestyle.
“Several factors contribute to the early and frequent development of cardiovascular disease in this population, including genetic vulnerability 5 , metabolic adverse effects of antipsychotics 6,7 , insufficient treatment of somatic comorbidity 8 , and unhealthy lifestyle 9 .”
Psychotropic medication use, including antidepressants, lithium and antipsychotic medications, is associated with higher T2DM prevalence.
“Our data confirm prior evidence that psychotropic medication use, including that of antidepressants, lithium and antipsychotic medications 26 , is associated with higher T2DM prevalence.”
From Diabetes mellitus in people with schizophrenia, bipolar disorder and major depressive disorder: a systematic review and large scale meta‐analysis (2016) · cites this paper as [26]
Other diagnostic-independent factors likely influence T2DM frequency, including hyperglycaemia following psychotropic medication use and long-term exposure to unhealthy lifestyle behaviors, as well as potential genetic factors linking psychiatric and medical risk.
“Thus, other diagnosticindependent factors likely influence T2DM frequency, including hyperglycaemia following psychotropic medication use 26 and long-term exposure to unhealthy lifestyle behaviors 27,28 , as well as potential genetic factors linking psychiatric and medical risk 29 .”
From Diabetes mellitus in people with schizophrenia, bipolar disorder and major depressive disorder: a systematic review and large scale meta‐analysis (2016) · cites this paper as [26]
Osteoporosis and increased risk of bone fractures have been linked to antipsychotic treatment.
“more recently, osteoporosis and increased risk of bone fractures have also been linked to antipsychotic treatment (3).”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Part of this paper’s reference list could not be split into single entries.
Overweight, Obesity, and Depression: A Systematic Review and Meta-analysis of Longitudinal Studies
Luppino, F. S., de Wit, L. M., Bouvy, P. F., Stijnen, T., Cuijpers, P., Penninx, B. W. J. H., & Zitman, F. G. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.2 · Cited by 4,322 · see citing works
Leucht, S., Cipriani, A., Spineli, L., Mavridis, D., Örey, D., Richter, F., Samara, M., Barbui, C., Engel, R. R., Geddes, J. R., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60733-3 · Cited by 2,561 · see citing works
DE HERT, M., CORRELL, C. U., BOBES, J., CETKOVICH‐BAKMAS, M., COHEN, D., ASAI, I., DETRAUX, J., GAUTAM, S., MÖLLER, H., NDETEI, D. M., et al. (2011) · World Psychiatry · doi:10.1002/j.2051-5545.2011.tb00014.x · Cited by 2,488 · see citing works
Self-citationBreast cancer statistics, 2013
Desantis, C. E., Ma, J., Bryan, L. N., & Jemal, A. (2013) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21203 · Cited by 2,142 · see citing works
Risks of all-cause and suicide mortality in mental disorders: a meta-review
Chesney, E., Goodwin, G. M., & Fazel, S. (2014) · World Psychiatry · doi:10.1002/wps.20128 · Cited by 2,115 · see citing works
Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis
Leucht, S., Corves, C., Arbter, D., Engel, R. R., Li, C., & Davis, J. M. (2009) · The Lancet · doi:10.1016/s0140-6736(08)61764-x · Cited by 1,930 · see citing works
Ma, J., & Jemal, A. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5647-6_1 · Cited by 1,918 · see citing works
Tiihonen, J., Lönnqvist, J., Wahlbeck, K., Klaukka, T., Niskanen, L., Tanskanen, A., & Haukka, J. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60742-x · Cited by 1,354 · see citing works
Meta-analysis of the Impact of 9 Medication Classes on Falls in Elderly Persons
Woolcott, J. C. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.357 · Cited by 1,326 · cited 1× · see citing works
“Most studies and reviews (157,203,217-223) found signif-”
Mcevoy, J., Meyer, J., Goff, D., Nasrallah, H., Davis, S., Sullivan, L., Meltzer, H., Hsiao, J. K., Stroup, T., & Lieberman, J. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2005.07.014 · Cited by 1,220 · see citing works
Atypical antipsychotic drugs and the risk of sudden cardiac death
Ray, W. A., Chung, C. P., Murray, K. T., Hall, K., & Stein, C. M. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0806994 · Cited by 1,194 · see citing works
Metabolic and cardiovascular adverse effects associated with antipsychotic drugs.
De Hert, M., Detraux, J., van Winkel, R., Yu, W., & Correll, C. U. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.156 · Cited by 1,145 · see citing works
Mitchell, A. J., Vancampfort, D., Sweers, K., van Winkel, R., Yu, W., & Binder, M. D. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr148 · Cited by 1,087 · see citing works
Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis
Cipriani, A., Hawton, K., Stockton, S., & Geddes, J. R. (2013) · BMJ · doi:10.1136/bmj.f3646 · Cited by 920 · cited 1× · see citing works
“Furthermore, clozapine (4), antidepressants (282), and lithium (283), as well as antiepileptics (284), are associ-”
BackgroundLithium toxicity profile: a systematic review and meta-analysis
McKnight, R. F., Adida, M., Budge, K., Stockton, S., Goodwin, G. M., & Geddes, J. R. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61516-x · Cited by 881 · see citing works
Correll, C. U., Leucht, S., & Kane, J. M. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.3.414 · Cited by 709 · see citing works
Self-citationRummel‐Kluge, C., Komossa, K., Schwarz, S., Hunger, H., Schmid, F., Lobos, C. A., Kissling, W., Davis, J. M., & Leucht, S. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.07.012 · Cited by 679 · see citing works
Comorbidities and Mortality in Bipolar Disorder: A Swedish National Cohort Study
Crump, C., Sundquist, K., Winkleby, M. A., & Sundquist, J. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.1394 · Cited by 677 · see citing works
Physical illness and schizophrenia: a review of the literature
Leucht, S., Burkard, T., Henderson, J., Maj, M., & Sartorius, N. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2007.01095.x · Cited by 633 · see citing works
Association of Diabetes Mellitus With Use of Atypical Neuroleptics in the Treatment of Schizophrenia
Sernyak, M. J., LESLIE, D. L., Alarcón, R. D., LOSONCZY, M. F., & Rosenheck, R. A. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.4.561 · Cited by 623 · see citing works
Antidepressants and Body Weight: A Comprehensive Review and Meta-Analysis
Serretti, A., & Mandelli, L. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.09r05346blu · Cited by 621 · cited 1× · see citing works
“monozygotic twin and sibling studies, suggests that genetic factors play an important role in medication-induced weight gain (43-45), with estimates as high as 60-80% for antipsychotic-related weight gain (46).”
BackgroundTwenty-five year mortality of a community cohort with schizophrenia
Brown, S., Kim, M., Mitchell, C., & Inskip, H. (2010) · British Journal of Psychiatry · doi:10.1192/bjp.bp.109.067512 · Cited by 601 · see citing works
Lithium toxicity profi le: a systematic review and meta-analysis
McKnight, R. F., Budge, K., Ba, S., Goodwin, G. M., Geddes, J. R., & Adida, M. (2012) · Cited by 544 · see citing works
Life expectancy and cardiovascular mortality in persons with schizophrenia
Laursen, T. M., Munk-Olsen, T., & Vestergaard, M. (2012) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32835035ca · Cited by 518 · see citing works
Life expectancy among persons with schizophrenia or bipolar affective disorder
Laursen, T. M. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.06.008 · Cited by 508 · see citing works
Almost All Antipsychotics Result in Weight Gain: A Meta-Analysis
Bak, M., Fransen, A., Janssen, J., van Os, J., & Drukker, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094112 · Cited by 490 · see citing works
Stahl, S. M., Grady, M. M., Moret, C., & Briley, M. (2005) · CNS Spectrums · doi:10.1017/s1092852900019726 · Cited by 462 · see citing works
Vancampfort, D., Vansteelandt, K., Correll, C. U., Mitchell, A. J., Herdt, A. D., Sienaert, P. A., Probst, M., & Binder, M. D. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12050620 · Cited by 441 · see citing works
Self-citationHasan, A., Falkai, P., Wobrock, T., Lieberman, J. A., Glenthoj, B. Y., Gattaz, W. F., Thibaut, F., Möller, H., & WFSBP Task force on Treatment Guidelines for Schizophrenia (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2012.739708 · Cited by 418 · see citing works
Metabolic side effects of antipsychotic drug treatment – pharmacological mechanisms
Reynolds, G. P., & Kirk, S. L. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.10.010 · Cited by 400 · see citing works
Tardive dyskinesia and new antipsychotics
Correll, C. U., & Schenk, E. M. (2008) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e3282f53132 · Cited by 367 · see citing works
Self-citationHert, M. A. F. D., Dobbelaere, M., Sheridan, E. M., Cohen, D., & Correll, C. U. (2011) · European Psychiatry · doi:10.1016/j.eurpsy.2010.09.011 · Cited by 365 · see citing works
Self-citationPeuskens, J., Pani, L., Detraux, J., & De Hert, M. (2014) · CNS Drugs · doi:10.1007/s40263-014-0157-3 · Cited by 350 · see citing works
Self-citationRingen, P. A., Engh, J. A., Birkenaes, A. B., Dieset, I., & Andreassen, O. A. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00137 · Cited by 347 · see citing works
Medication-Related Falls in the Elderly
Huang, A. R., Mallet, L., Rochefort, C. M., Eguale, T., Buckeridge, D. L., & Tamblyn, R. M. (2012) · Drugs & Aging · doi:10.2165/11599460-000000000-00000 · Cited by 345 · see citing works
QTc Prolongation, Torsades de Pointes, and Psychotropic Medications
Beach, S. R., Celano, C. M., Noseworthy, P. A., Januzzi, J. L., & Huffman, J. C. (2013) · Psychosomatics · doi:10.1016/j.psym.2012.11.001 · Cited by 343 · see citing works
Power, R. A., Kyaga, S., Uher, R., MacCabe, J. H., Långström, N., Landen, M., McGuffin, P., Lewis, C. M., Lichtenstein, P., & Svensson, A. C. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.268 · Cited by 336 · see citing works
Mitchell, A. J., Vancampfort, D., Herdt, A. D., Yu, W., & Hert, M. D. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs082 · Cited by 331 · see citing works
Lithium nephrotoxicity revisited
Grünfeld, J., & Rossier, B. C. (2009) · Nature Reviews Nephrology · doi:10.1038/nrneph.2009.43 · Cited by 327 · see citing works
Vancampfort, D., Wampers, M., Mitchell, A. J., Correll, C. U., Herdt, A. D., Probst, M., & Binder, M. D. (2013) · World Psychiatry · doi:10.1002/wps.20069 · Cited by 320 · see citing works
Self-citationVancampfort, D., Correll, C. U., Wampers, M., Sienaert, P., Mitchell, A. J., De Herdt, A., Probst, M., Scheewe, T. W., & De Hert, M. (2014) · Psychological Medicine · doi:10.1017/s0033291713002778 · Cited by 317 · see citing works
Self-citationLong-Term Use of Antidepressants for Depressive Disorders and the Risk of Diabetes Mellitus
Andersohn, F., Schade, R., Suissa, S., & Garbe, E. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08071065 · Cited by 315 · see citing works
Premature Mortality From General Medical Illnesses Among Persons With Bipolar Disorder: A Review
Roshanaei-Moghaddam, B., & Katon, W. (2009) · Psychiatric Services · doi:10.1176/ps.2009.60.2.147 · Cited by 305 · see citing works
Tardive dyskinesia and new antipsychotics
Correll, C. U., & Schenk, E. M. (2008) · Current Opinion in Internal Medicine · doi:10.1097/mci.0b013e328303e7a6 · Cited by 291 · see citing works
Self-citationReview of Lithium Effects on Brain and Blood
Young, W. (2009) · Cell Transplantation · doi:10.3727/096368909x471251 · Cited by 287 · see citing works
Antidepressant-Induced Liver Injury: A Review for Clinicians
Voican, C. S., Corruble, E., Naveau, S., & Perlemuter, G. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13050709 · Cited by 277 · see citing works
Smith, M. J., Hopkins, D., Peveler, R., Holt, R. I. G., Woodward, M., & Ismail, K. (2008) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.107.037184 · Cited by 274 · see citing works
Correll, C. U. (2010) · European Psychiatry · doi:10.1016/s0924-9338(10)71701-6 · Cited by 272 · see citing works
Self-citationThe epidemiology of excess mortality in people with mental illness
Lawrence, D., Kisely, S., & Pais, J. (2010) · The Canadian Journal of Psychiatry · doi:10.1177/070674371005501202 · Cited by 258 · see citing works
Polypharmacy With Antipsychotics, Antidepressants, or Benzodiazepines and Mortality in Schizophrenia
Tiihonen, J. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1532 · Cited by 253 · see citing works
Maayan, L. A., & Correll, C. U. (2011) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2011.0015 · Cited by 253 · see citing works
Self-citationMeta-Analysis of Selective Serotonin Reuptake Inhibitor–Associated QTc Prolongation
Beach, S. R., Kostis, W. J., Celano, C. M., Januzzi, J. L., Ruskin, J. N., Noseworthy, P. A., & Huffman, J. C. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13r08672 · Cited by 253 · cited 1× · see citing works
“, citalopram) (125,126) may be associated with (modest) QTc prolongation.”
BackgroundRubin, R. R., Ma, Y., Marrero, D. G., Peyrot, M., Barrett-Connor, E. L., Kahn, S. E., Haffner, S. M., Price, D. W., Knowler, W. C., & for the Diabetes Prevention Program Research Group (2008) · Diabetes Care · doi:10.2337/dc07-1827 · Cited by 242 · see citing works
Termination of Clozapine Treatment Due to Medical Reasons
Nielsen, J., Correll, C. U., Manu, P., & Kane, J. M. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12r08064 · Cited by 232 · see citing works
Self-citationCasey, D. E., Daniel, D. G., Wassef, A. A., Tracy, K. A., Wozniak, P., & Sommerville, K. W. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300023 · Cited by 232 · see citing works
Lopresti, A. L., & Drummond, P. D. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.05.005 · Cited by 231 · see citing works
Antipsychotics and the Risk of Type 2 Diabetes Mellitus in Children and Youth
Bobo, W. V., Cooper, W. O., Stein, C. M., Olfson, M., Graham, D. J., Daugherty, J. R., Fuchs, D. C., & Ray, W. A. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.2053 · Cited by 229 · see citing works
Neurological complications of psychiatric drugs: clinical features and management
Haddad, P. M., & Dursun, S. M. (2007) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.918 · Cited by 223 · see citing works
Cardiovascular Morbidity and Mortality in Bipolar Disorder
Weiner, M., Warren, L. L., & Fiedorowicz, J. G. (2011) · Annals of Clinical Psychiatry · doi:10.1177/104012371102300107 · Cited by 221 · see citing works
Pappa, S., & Dazzan, P. (2008) · Psychological Medicine · doi:10.1017/s0033291708004716 · Cited by 218 · see citing works
Lithium's effect on bone mineral density
Zamani, A., Omrani, G. R., & Nasab, M. M. (2008) · Bone · doi:10.1016/j.bone.2008.10.001 · Cited by 213 · see citing works
Antipsychotic treatment and mortality in schizophrenia.
Torniainen, M., Mittendorfer-Rutz, E., Tanskanen, A., Bjorkenstam, C., Suvisaari, J., Alexanderson, K., & Tiihonen, J. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu164 · Cited by 208 · see citing works
Nielsen, J., Skadhede, S., & Correll, C. U. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.78 · Cited by 207 · see citing works
Self-citationCatalá-López, F., Suárez‐Pinilla, M., Suárez‐Pinilla, P., Valderas, J. M., Gómez-Beneyto, M., Martı́nez, S., Balanzá‐Martínez, V., Climent, J., Valencia, A., McGrath, J. J., et al. (2014) · Psychotherapy and Psychosomatics · doi:10.1159/000356498 · Cited by 201 · see citing works
Dopamine Antagonists and the Development of Breast Cancer
Wang, P. S., Walker, A. M., Tsuang, M. T., Orav, E. J., Glynn, R. J., Levin, R., & Avorn, J. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.12.1147 · Cited by 196 · see citing works
Antidepressant Medication Use, Weight Gain, and Risk of Type 2 Diabetes
Mika Kivimaki, B., Hamer, M., Batty, G. D., Geddes, J. R., Tabák, Á. G., Pentti, J., Virtanen, M., & Vahtera, J. (2010) · Diabetes Care · doi:10.2337/dc10-1187 · Cited by 196 · see citing works
Depression and coronary artery disease: the association, mechanisms, and therapeutic implications.
Khawaja, I. S., Westermeyer, J. J., Gajwani, P., & Feinstein, R. E. (2009) · PubMed Central · Cited by 196 · see citing works
Atypical antipsychotics and glucose dysregulation: a systematic review
Jin, H., Meyer, J. M., & Jeste, D. V. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.03.024 · Cited by 195 · see citing works
Weight effects associated with antipsychotics: A comprehensive database analysis
Parsons, B., Allison, D. B., Loebel, A. D., Williams, K., Giller, E. L., Romano, S. J., & SIU, C. O. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2008.09.025 · Cited by 191 · see citing works
Antidepressant medications and osteoporosis
Rizzoli, R., Cooper, C. C., Reginster, J., Abrahamsen, B., Adachi, J. D., Brandi, M. L., Bruyère, O., Compston, J. E., Ducy, P. F., Ferrari, S., et al. (2012) · Bone · doi:10.1016/j.bone.2012.05.018 · Cited by 188 · see citing works
Bresee, L. C., Majumdar, S., Patten, S., & Johnson, J. A. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2009.12.016 · Cited by 187 · see citing works
Antidepressants and the Risk of Hyponatremia: A Class-by-Class Review of Literature
Picker, L. D., Eede, F. V. D., Dumont, G., Moorkens, G. H., & Sabbe, B. (2014) · Psychosomatics · doi:10.1016/j.psym.2014.01.010 · Cited by 186 · see citing works
Renal failure occurs in chronic lithium treatment but is uncommon
Bendz, H., Schön, S., Attman, P., & Aurell, M. (2009) · Kidney International · doi:10.1038/ki.2009.433 · Cited by 183 · see citing works
Diabetes mellitus and severe mental illness: mechanisms and clinical implications
Holt, R. I. G., & Mitchell, A. J. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.203 · Cited by 181 · see citing works
Anothaisintawee, T., Wiratkapun, C., Lerdsitthichai, P., Kasamesup, V., Wongwaisayawan, S., Srinakarin, J., Hirunpat, S., Woodtichartpreecha, P., Boonlikit, S., Teerawattananon, Y., et al. (2013) · Asia Pacific Journal of Public Health · doi:10.1177/1010539513488795 · Cited by 179 · see citing works
The burden of obesity among adults with bipolar disorder in the United States
Goldstein, B. I., Liu, S.-M., Zivkovic, N., Schaffer, A., Chien, L.-C., & Blanco, C. (2011) · Bipolar Disorders · doi:10.1111/j.1399-5618.2011.00932.x · Cited by 173 · see citing works
Antidepressant Medication as a Risk Factor for Type 2 Diabetes and Impaired Glucose Regulation
Barnard, K. D., Peveler, R., & Holt, R. I. G. (2013) · Diabetes Care · doi:10.2337/dc13-0560 · Cited by 172 · see citing works
QT Alterations in Psychopharmacology: Proven Candidates and Suspects
Alvarez, P. A., & Pahissa, J. (2009) · Current Drug Safety · doi:10.2174/157488610789869265 · Cited by 172 · see citing works
Patel, J. K., Buckley, P. F., Woolson, S., Hamer, R. M., McEvoy, J. P., Perkins, D. O., Lieberman, J. A., & for the CAFE investigators (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.03.025 · Cited by 169 · see citing works
Matsen, C. B., & Neumayer, L. A. (2013) · JAMA Surgery · doi:10.1001/jamasurg.2013.3393 · Cited by 167 · see citing works
Association of Community-Acquired Pneumonia With Antipsychotic Drug Use in Elderly Patients
Trifirò, G., Gambassi, G., Sen, E. F., Caputi, A. P., Bagnardi, V., Brea, J. M., & Sturkenboom, M. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-7-201004060-00006 · Cited by 165 · see citing works
Depression as a risk factor for osteoporosis
Cizza, G., Primma, S., & Csákó, G. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.05.003 · Cited by 163 · see citing works
Binder, M. D., Yu, W., Detraux, J., Sweers, K., van Winkel, R., & Correll, C. U. (2012) · CNS Drugs · doi:10.2165/11634500-000000000-00000 · Cited by 162 · see citing works
Self-citationSecond-Generation Antipsychotic Medications and Risk of Pneumonia in Schizophrenia
Kuo, C., Yang, S.-Y., Liao, Y., et al. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr202 · Cited by 162 · see citing works
Schizophrenia and the risk of cardiovascular diseases: a meta-analysis of thirteen cohort studies.
Fan, Z.-X., Wu, Y., Shen, J., Ji, T., & Zhan, R. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.07.011 · Cited by 157 · see citing works
Relationship Between Antiepileptic Drugs and Suicide Attempts in Patients With Bipolar Disorder
Gibbons, R. D., Hur, K., Brown, C. H., & Mann, J. J. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.159 · Cited by 156 · see citing works
Manu, P., Sarpal, D. K., Muir, O. S., et al. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.10.014 · Cited by 154 · see citing works
Hasnain, M., & Vieweg, W. V. R. (2014) · CNS Drugs · doi:10.1007/s40263-014-0196-9 · Cited by 153 · see citing works
Effects of Antipsychotic Medications on Appetite, Weight, and Insulin Resistance
Deng, C. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.05.006 · Cited by 152 · see citing works
An Electronic Health Records Study of Long-Term Weight Gain Following Antidepressant Use
Blumenthal, S. R., Castro, V. M., Clements, C. C., Rosenfield, H. R., Murphy, S. N., Fava, M., Weilburg, J. B., Erb, J. L., Churchill, S. E., Kohane, I. S., et al. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.414 · Cited by 151 · see citing works
Depression and Osteoporosis: A Research Synthesis with Meta-Analysis
Cizza, G., Primma, S., Coyle, M., Gourgiotis, L., & Csákó, G. (2010) · Hormone and Metabolic Research · doi:10.1055/s-0030-1252020 · Cited by 150 · see citing works
The relationship between bipolar disorder and type 2 diabetes: More than just co-morbid disorders
Calkin, C., Gardner, D. M., Ransom, T. P. P., & Alda, M. (2012) · Annals of Medicine · doi:10.3109/07853890.2012.687835 · Cited by 150 · see citing works
Wu, Q. F., Bencaz, A. F., Hentz, J. G., & Crowell, M. D. (2011) · Osteoporosis International · doi:10.1007/s00198-011-1778-8 · Cited by 148 · see citing works
Second-generation antipsychotics and constipation: A review of the literature
Hert, M. D., Hudyana, H., Dockx, L., Bernagie, C., Sweers, K., Tack, J. F., Leucht, S., & Peuskens, J. (2010) · European Psychiatry · doi:10.1016/j.eurpsy.2010.03.003 · Cited by 148 · see citing works
Disruption of the Dopamine D2 Receptor Impairs Insulin Secretion and Causes Glucose Intolerance
García-Tornadú, I., Ornstein, A. M., Chamson-Reig, A., Wheeler, M. B., Hill, D. J., Arany, E. J., Rubinstein, M., & Becú‐Villalobos, D. (2010) · Endocrinology · doi:10.1210/en.2009-0996 · Cited by 147 · see citing works
Chou, F. H., Tsai, K., Su, C., & Lee, C. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.02.018 · Cited by 147 · see citing works
Metabolic and endocrine effects of valproic acid chronic treatment
Belcastro, V., D’Egidio, C., Striano, P., & Verrotti, A. (2013) · Epilepsy Research · doi:10.1016/j.eplepsyres.2013.08.016 · Cited by 145 · see citing works
Atypical Antipsychotics and Pituitary Tumors: A Pharmacovigilance Study
Szarfman, A., Tonning, J. M., Levine, J. G., & Doraiswamy, P. M. (2006) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.26.6.748 · Cited by 143 · see citing works
Coupland, C. A. C., Dhiman, P., Barton, G., Morriss, R. K., Arthur, A. J., Sach, T., & Hippisley‐Cox, J. (2011) · Health Technology Assessment · doi:10.3310/hta15280 · Cited by 142 · see citing works
Hartling, L., Abou-Setta, A. M., Dursun, S. M., Mousavi, S. S., Pasichnyk, D., & Newton, A. S. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-157-7-201210020-00525 · Cited by 140 · see citing works
Hyperprolactinemia associated with psychotropics—a review
Madhusoodanan, S., Parida, S., & Jiménez, C. (2010) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1116 · Cited by 137 · see citing works
Pérez‐Iglesias, R., Martínez‐García, O., Pardo‐García, G., Amado, J., García‐Unzueta, M. T., Tabarés‐Seisdedos, R., & Crespo‐Facorro, B. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713001053 · Cited by 132 · see citing works
Molecular pathophysiology of metabolic effects of antipsychotic medications
Ballon, J. S., Pajvani, U. B., Freyberg, Z., Leibel, R. L., & Lieberman, J. A. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.07.004 · Cited by 130 · see citing works
Effects of antidepressants on glucose metabolism and diabetes mellitus type 2 in adults
Deuschle, M. (2012) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32835a4206 · Cited by 130 · see citing works
Obesity in Bipolar Disorder: An Overview
McElroy, S. L., & Keck, P. E. (2012) · Current Psychiatry Reports · doi:10.1007/s11920-012-0313-8 · Cited by 124 · see citing works
Psychotropic Drug-Induced Falls in Older People
Hill, K., & Wee, R. (2011) · Drugs & Aging · doi:10.2165/11598420-000000000-00000 · Cited by 124 · see citing works
Hodge, J. M., Wang, Y., Berk, M., Collier, F., Fernandes, T. J., Constable, M. J., Pasco, J. A., Dodd, S., Nicholson, G. C., Kennedy, R. L., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.11.003 · Cited by 122 · see citing works
Relationship between use of antidepressants and risk of fractures: a meta-analysis
Rabenda, V., Nicolet, D., Beaudart, C., Bruyère, O., & Reginster, J.-Y. (2012) · Osteoporosis International · doi:10.1007/s00198-012-2015-9 · Cited by 121 · see citing works
Clinically relevant interactions between newer antidepressants and second-generation antipsychotics
Spina, E., & de León, J. (2014) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2014.885504 · Cited by 121 · see citing works
Osteoporosis and fracture risk in people with schizophrenia
Kishimoto, T., Binder, M. D., Carlson, H. E., Manu, P., & Correll, C. U. (2012) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e328355e1ac · Cited by 116 · see citing works
Self-citationMajor Depression Is a Risk Factor for Low Bone Mineral Density: A Meta-Analysis
Yirmiya, R., & Bab, I. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.03.016 · Cited by 114 · see citing works
Effects of chronic lithium treatment on renal function
Tredget, J., Kirov, A., & Kirov, G. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.04.018 · Cited by 113 · see citing works
Cerebrovascular Accidents in Elderly People Treated with Antipsychotic Drugs
Sacchetti, E., Turrina, C., & Valsecchi, P. (2010) · Drug Safety · doi:10.2165/11319120-000000000-00000 · Cited by 113 · see citing works
Huybrechts, K. F., Rothman, K. J., Silliman, R. A., Brookhart, A. M., & Schneeweiß, S. (2011) · Canadian Medical Association Journal · doi:10.1503/cmaj.101406 · Cited by 112 · see citing works
The adverse skeletal effects of selective serotonin reuptake inhibitors
Tsapakis, E.-M., Gamie, Z., Tran, G. T., Adshead, S., Lampard, A. L., Mantalaris, A., & Tsiridis, E. E. (2011) · European Psychiatry · doi:10.1016/j.eurpsy.2010.10.006 · Cited by 112 · see citing works
Schneider, C., Corrigall, R. J., Hayes, D., Kyriakopoulos, M., & Frangou, S. (2013) · European Psychiatry · doi:10.1016/j.eurpsy.2013.08.001 · Cited by 110 · see citing works
Second Generation Antipsychotic-Induced Type 2 Diabetes: A Role for the Muscarinic M3 Receptor
Weston–Green, K., Huang, X., & Deng, C. (2013) · CNS Drugs · doi:10.1007/s40263-013-0115-5 · Cited by 108 · see citing works
Seriwatanachai, D., Krishnamra, N., & van Leeuwen, J. P. T. M. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22161 · Cited by 105 · see citing works
Selective Serotonin Reuptake Inhibitors and the Risk of Osseointegrated Implant Failure
Wu, X., Al‐Abedalla, K., Rastikerdar, E., Nader, S. A., Daniel, N. G., Nicolau, B. F., & Tamimi, F. (2014) · Journal of Dental Research · doi:10.1177/0022034514549378 · Cited by 104 · see citing works
Ji, J., Sundquist, K., Ning, Y., Kendler, K. S., Sundquist, J., & Chen, X. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs065 · Cited by 104 · see citing works
Yood, M. U., DeLorenze, G. N., Quesenberry, C. P., Oliveria, S. A., Tsai, A., Willey, V. J., McQuade, R. D., Newcomer, J. W., & L'Italien, G. J. (2009) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1781 · Cited by 103 · see citing works
Antipsychotic Use and the Risk of Hip Fracture Among Older Adults Afflicted With Dementia
Jalbert, J. J., Eaton, C. B., Miller, S. C., & Lapane, K. L. (2010) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2009.10.001 · Cited by 103 · see citing works
Correll, C. U., Joffe, B. I., Rosen, L. M., Sullivan, T. B., & Joffe, R. T. (2015) · World Psychiatry · doi:10.1002/wps.20187 · Cited by 102 · see citing works
Self-citationAntipsychotic-Induced Hyponatraemia
Meulendijks, D., Mannesse, C. K., Jansen, P. A. F., van Marum, R. J., & Egberts, T. C. G. (2010) · Drug Safety · doi:10.2165/11319070-000000000-00000 · Cited by 100 · see citing works
Bliziotes, M. M. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0861 · Cited by 99 · see citing works
Ronaldson, K. J., Fitzgerald, P. B., Taylor, A. J., Topliss, D. J., & McNeil, J. J. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.01.017 · Cited by 99 · see citing works
Metabolic Syndrome in Bipolar Disorder
McElroy, S. L., & Keck, P. E. (2014) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13r08634 · Cited by 99 · see citing works
Clozapine and therapeutic drug monitoring: is there sufficient evidence for an upper threshold?
Remington, G. J., Agid, O., Foussias, G., Ferguson, L., McDonald, K., & Powell, V. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2922-7 · Cited by 99 · see citing works
Hert, M. A. F. D., Peuskens, J., Sabbe, T., Mitchell, A. J., Stubbs, B., Neven, P., Wildiers, H. P. M. W., & Detraux, J. (2015) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12459 · Cited by 98 · see citing works
Self-citationWatanabe, N., Omori, I. M., Nakagawa, A., Cipriani, A., Barbui, C., McGuire, H., Churchill, R. C., & Furukawa, T. A. (2009) · CNS Drugs · doi:10.2165/11319480-000000000-00000 · Cited by 95 · see citing works
Oderda, L. H., Young, J. R., Asche, C. V., & Pepper, G. A. (2012) · Annals of Pharmacotherapy · doi:10.1345/aph.1q589 · Cited by 94 · cited 3× · see citing works
“(158,220,224), possibly due to extrapyramidal symptoms causing gait disturbances and impairing mobility and bal-”
BackgroundResultHasnain, M., Vieweg, W. V. R., & Hollett, B. (2012) · Postgraduate Medicine · doi:10.3810/pgm.2012.07.2577 · Cited by 93 · see citing works
Clinical presentation and management of drug-induced agranulocytosis
Andrès, E., Zimmer, J., Mecili, M., et al. (2011) · Expert Review of Hematology · doi:10.1586/ehm.11.12 · Cited by 93 · see citing works
Scigliano, G., & Ronchetti, G. (2013) · CNS Drugs · doi:10.1007/s40263-013-0054-1 · Cited by 92 · see citing works
Use of antidepressant drugs and risk of osteoporotic and non-osteoporotic fractures
Verdel, B. M., Souverein, P. C., Egberts, T. C. G., van Staa, T. P., Leufkens, H. G. M., & de Vries, F. (2010) · Bone · doi:10.1016/j.bone.2010.06.006 · Cited by 92 · see citing works
Type of antidepressant therapy and risk of type 2 diabetes in people with depression
Brown, L. C., Majumdar, S. R., & Johnson, J. A. (2007) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2007.07.009 · Cited by 92 · see citing works
A meta-analysis of prevalence estimates and moderators of low bone mass in people with schizophrenia
Stubbs, B., De Hert, M., Sepehry, A. A., Correll, C. U., Mitchell, A. J., Soundy, A., Detraux, J., & Vancampfort, D. (2014) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12313 · Cited by 92 · see citing works
Self-citationSudden unexpected death in schizophrenia: Autopsy findings in psychiatric inpatients
Ifteni, P., Correll, C. U., Burtea, V., Kane, J. M., & Manu, P. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.03.011 · Cited by 91 · cited 1× · see citing works
“Patients with schizophrenia have been reported to be 2-4 times more likely to experience sudden cardiac death (SCD) than the general population (130,131).”
BackgroundSelf-citationExcess Mortality in Bipolar Disorders
Miller, C. J., & Bauer, M. S. (2014) · Current Psychiatry Reports · doi:10.1007/s11920-014-0499-z · Cited by 91 · see citing works
Lin, G., Chen, Y.-J., Kuo, D.-J., Jaiteh, L. E. S., Wu, Y., Lo, T.-S., & Li, Y.-H. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr162 · Cited by 90 · see citing works
Fleischhacker, W. W., SIU, C. O., Bodén, R., Pappadopulos, E. A., Karayal, O. N., Kahn, R. S., & the EUFEST study group (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712001241 · Cited by 89 · see citing works
Use of anti-depressants and the risk of fracture of the hip or femur
van den Brand, M. W. M., Samson, M., Pouwels, S., van Staa, T. P., Thio, B., Cooper, C. C., Leufkens, H. G. M., Egberts, T. C. G., Verhaar, H. J. J., & de Vries, F. (2009) · Osteoporosis International · doi:10.1007/s00198-009-0849-6 · Cited by 89 · see citing works
de Moura, C. S., Bernatsky, S., Abrahamowicz, M., Παπαϊωάννου, Α., Bessette, L., Adachi, J. D., Goltzman, D., Prior, J. C., Kreiger, N., Towheed, T., et al. (2014) · Osteoporosis International · doi:10.1007/s00198-014-2649-x · Cited by 88 · see citing works
Antipsychotic drugs: Pro-cancer or anti-cancer? A systematic review
Fond, G. B., Macgregor, A., Attal, J., Larue, A., Brittner, M., Ducasse, D., & Capdevielle, D. (2012) · Medical Hypotheses · doi:10.1016/j.mehy.2012.03.026 · Cited by 87 · see citing works
The impact of mental illness on cardiac outcomes: A review for the cardiologist
Sowden, G. L., & Huffman, J. C. (2008) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.10.002 · Cited by 86 · see citing works
Kelly, D. L., & Conley, R. R. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0111 · Cited by 86 · see citing works
Antipsychotic use and the risk of hip/femur fracture: a population-based case–control study
Pouwels, S., van Staa, T. P., Egberts, T. C. G., Leufkens, H. G. M., Cooper, C. C., & de Vries, F. (2009) · Osteoporosis International · doi:10.1007/s00198-008-0826-5 · Cited by 86 · see citing works
Calarge, C. A., Zimmerman, B. M., Xie, D., Samuel Kuperman, C., & Schlechte, J. (2010) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04595gre · Cited by 85 · see citing works
Cancer incidence in a sample of Maryland residents with serious mental illness
McGinty, E., Zhang, Y.-Y., Guallar, E., Ford, D., Steinwachs, D., Dixon, L., Keating, N., & Daumit, G. (2012) · Psychiatric Services · doi:10.1176/appi.ps.201100169 · Cited by 84 · see citing works
Bakken, M. S., Engeland, A., Engesaeter, L. B., Ranhoff, A. H., Hunskaar, S., & Ruths, S. (2013) · Age and Ageing · doi:10.1093/ageing/aft009 · Cited by 83 · see citing works
Epileptogenic drugs: a systematic review
Ruffmann, C., Bogliun, G., & Beghi, E. (2006) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.6.4.575 · Cited by 82 · see citing works
Update on Medications With Adverse Skeletal Effects
Davidge-Pitts, C. J., & Kearns, A. E. (2011) · Mayo Clinic Proceedings · doi:10.4065/mcp.2010.0636 · Cited by 82 · see citing works
Antidepressant-Induced Hyperprolactinaemia
Coker, F., & Taylor, D. M. (2010) · CNS Drugs · doi:10.2165/11533140-000000000-00000 · Cited by 80 · see citing works
The Effects of Lithium on Renal Function in Older Adults—A Systematic Review
Rej, S., Herrmann, N., & Shulman, K. I. (2012) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988712436690 · Cited by 80 · see citing works
Pharmacotherapy and the risk for community-acquired pneumonia
Gau, J., Acharya, U. H., Khan, S. A., Heh, V., Mody, L., & Kao, T.-C. (2010) · BMC Geriatrics · doi:10.1186/1471-2318-10-45 · Cited by 79 · see citing works
Fiedorowicz, J. G., Miller, D. D., Bishop, J. R., Calarge, C. A., Ellingrod, V. L., & Haynes, W. G. (2012) · Current Psychiatry Reviews · doi:10.2174/157340012798994867 · Cited by 79 · see citing works
Comparative Safety of Antipsychotic Medications in Nursing Home Residents
Huybrechts, K. F., Schneeweiß, S., Gerhard, T., Olfson, M., Avorn, J., Levin, R., Lucas, J. A., & Crystal, S. (2012) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2011.03853.x · Cited by 78 · see citing works
The effect of antidepressants on lipid homeostasis: a cardiac safety concern?
McIntyre, R. S., Soczynska, J. K., Konarski, J. Z., & Kennedy, S. H. (2006) · Expert Opinion on Drug Safety · doi:10.1517/14740338.5.4.523 · Cited by 78 · see citing works
Antidepressant use and new‐onset diabetes: a systematic review and meta‐analysis
Bhattacharjee, S., Bhattacharya, R., Kelley, G. A., & Sambamoorthi, U. (2013) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2393 · Cited by 77 · see citing works
Kiviniemi, M., Suvisaari, J., Koivumaa-Honkanen, H. T., Häkkinen, U., Isohanni, M. K., & Hakko, H. H. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.07.043 · Cited by 77 · see citing works
Pratt, N. L., Roughead, E. E., Ramsay, E. N., Salter, A. B., & Ryan, P. (2011) · Drug Safety · doi:10.2165/11588470-000000000-00000 · Cited by 76 · see citing works
Lithium and chronic kidney disease
Kripalani, M., Shawcross, J., Reilly, J. G., et al. (2009) · BMJ · doi:10.1136/bmj.b2452 · Cited by 76 · see citing works
Leonard, C. E. (2012) · Journal of Clinical & Experimental Cardiology · doi:10.4172/2155-9880.s10-006 · Cited by 76 · see citing works
Bai, Y., Su, T., Chen, M., Chen, T., & Chang, W.-H. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.02.019 · Cited by 76 · see citing works
Antipsychotic Use and Myocardial Infarction in Older Patients With Treated Dementia
Fourrier-Réglat, A. (2012) · Archives of Internal Medicine · doi:10.1001/archinternmed.2012.28 · Cited by 75 · see citing works
Systematic Overview of Cochrane Reviews for Anticholinergic Effects of Antipsychotic Drugs
Ozbilen, M., & Adams, C. E. (2009) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31819a91f1 · Cited by 74 · see citing works
Ehrenpreis, E. D., Deepak, P., Sifuentes, H., Devi, R., Du, H., & Leikin, J. B. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.300 · Cited by 74 · see citing works
QTc Prolongation with Antipsychotics
Shah, A. A., Aftab, A., & Coverdale, J. (2014) · Journal of Psychiatric Practice · doi:10.1097/01.pra.0000450319.21859.6d · Cited by 72 · see citing works
Ratliff, J. C., Palmese, L. B., Reutenauer, E. L., Srihari, V. H., & Tek, C. (2012) · Psychosomatics · doi:10.1016/j.psym.2012.03.001 · Cited by 71 · see citing works
Reducing all-cause mortality among patients with psychiatric disorders: a population-based study
Kisely, S. R., Preston, N. J., Xiao, J., Lawrence, D. M., Louise, S., & Crowe, E. (2012) · Canadian Medical Association Journal · doi:10.1503/cmaj.121077 · Cited by 71 · see citing works
Murray‐Thomas, T., Jones, M., Patel, D., Brunner, E., Shatapathy, C. C., Motsko, S. P., & van Staa, T. P. (2013) · Cardiovascular Psychiatry and Neurology · doi:10.1155/2013/247486 · Cited by 71 · see citing works
Poluzzi, E., Raschi, E., Koci, A., Moretti, U., Spina, E., Behr, E. R., Sturkenboom, M., & Ponti, F. D. (2013) · Drug Safety · doi:10.1007/s40264-013-0032-z · Cited by 70 · see citing works
Yde, C. W., Clausen, M. P., Bennetzen, M. V., et al. (2009) · Anti-Cancer Drugs · doi:10.1097/cad.0b013e32832ec041 · Cited by 69 · see citing works
Mortality in schizophrenia and related psychoses: data from two cohorts, 1875–1924 and 1994–2010
Healy, D., Le Noury, J., Harris, M., Butt, M., Linden, S., Whitaker, C., Zou, L., & Roberts, A. P. (2012) · BMJ Open · doi:10.1136/bmjopen-2012-001810 · Cited by 69 · see citing works
Liver Injury Associated with Antidepressants
Park, S. J., & Ishino, R. (2013) · Current Drug Safety · doi:10.2174/1574886311308030011 · Cited by 67 · see citing works
Antipsychotic Drugs, Mood Stabilizers, and Risk of Pneumonia in Bipolar Disorder
Yang, S., Liao, Y., Liu, H., et al. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12m07938 · Cited by 67 · see citing works
Mika Kivimaki, B., Batty, G. D., Jokela, M. M., Ebmeier, K. P., Vahtera, J., Virtanen, M., Brunner, E. J., Tabák, Á. G., Witte, D. R., Meena Kumari, B., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.07.008 · Cited by 67 · see citing works
Baker, R. A., Pikalov, A., Tran, Q.-V., Kremenets, T., Arani, R. B., & Doraiswamy, P. M. (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4092 · Cited by 66 · see citing works
Antidepressant Use and Diabetes Mellitus Risk: A Meta-Analysis
Yoon, J. M., Cho, E.-G., Lee, H.-K., & Park, S. M. (2013) · Korean Journal of Family Medicine · doi:10.4082/kjfm.2013.34.4.228 · Cited by 66 · see citing works
Cerimele, J. M., & Katon, W. J. (2012) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2012.08.001 · Cited by 65 · see citing works
A review of the adverse effects and safety of noradrenergic antidepressants
Whiskey, E., & Taylor, D. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113492027 · Cited by 64 · see citing works
Antipsychotics and Abnormal Liver Function Tests
Marwick, K. F. M., Taylor, M., & Walker, S. W. (2012) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e31826818b6 · Cited by 64 · see citing works
The role of valproate in metabolic disturbances in bipolar disorder patients
Chang, H. H., Yang, Y. K., Gean, P. W., Huang, H. C., Chen, P. S., & Lu, R. B. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.12.011 · Cited by 64 · see citing works
Hematological Effects of Valproate in Psychiatric Patients
Vasudev, K., Keown, P., Gibb, I., & McAllister-Williams, H. (2010) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181db2684 · Cited by 63 · see citing works
Antidepressants and Fracture Risk in Older Adults: A Comparative Safety Analysis
Gagne, J., Patrick, A., Mogun, H., & Solomon, D. H. (2011) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2011.54 · Cited by 63 · see citing works
Cosgrove, L., Shi, L., Creasey, D. E., Anaya, M., Myers, J. A., & Huybrechts, K. F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018210 · Cited by 61 · see citing works
Hyponatraemia as an Adverse Drug Reaction of Antipsychotic Drugs
Mannesse, C. K., van Puijenbroek, E., Jansen, P. A. F., van Marum, R. J., Souverein, P. C., & Egberts, T. C. G. (2010) · Drug Safety · doi:10.2165/11532560-000000000-00000 · Cited by 60 · see citing works
Elmslie, J. L., Porter, R., Joyce, P. R., Hunt, P. J., Shand, B. I., & Scott, R. S. (2009) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048670802534341 · Cited by 58 · see citing works
Falls in very old people: The population-based Umeå 85+ Study in Sweden
Wågert, P. V. H., Gustafson, Y., Kallin, K., Jensen, J., & Lundin‐Olsson, L. (2009) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2008.12.005 · Cited by 58 · see citing works
Pharmacogenetic Aspects of Antipsychotic Drug-induced Weight Gain - A Critical Review
Reynolds, G. P. (2012) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2012.10.2.71 · Cited by 57 · see citing works
Risk of osteoporosis and fracture incidence in patients on antipsychotic medication
Graham, S. M., Howgate, D. J., Anderson, W. C., Howes, C., Heliotis, M., Mantalaris, A., Tsiridis, E. E., & Tsapakis, E.-M. (2011) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2011.560112 · Cited by 57 · see citing works
Crews, M., & Howes, O. D. (2012) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1265 · Cited by 57 · see citing works
Antipsychotic Drug Use and Community-Acquired Pneumonia
Trifirò, G. (2011) · Current Infectious Disease Reports · doi:10.1007/s11908-011-0175-y · Cited by 56 · see citing works
Association Between Antipsychotic Use and Risk of Acute Myocardial Infarction
Lin, S.-T., Chen, C., Tsang, H., Lee, C., Yang, P., Cheng, K.-D., Li, D., Wang, C.-J., Hsieh, Y.-C., & Yang, W. (2014) · Circulation · doi:10.1161/circulationaha.114.008779 · Cited by 55 · see citing works
Atypical antipsychotics and diabetic ketoacidosis: a review
Guenette, M. D., Hahn, M., Cohn, T. A., Teo, C., & Remington, G. J. (2013) · Psychopharmacology · doi:10.1007/s00213-013-2982-3 · Cited by 55 · see citing works
Raschi, E., Poluzzi, E., Godman, B., Koci, A., Moretti, U., Kalaba, M., Bennie, M., Barbui, C., Wettermark, B., Sturkenboom, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081208 · Cited by 55 · see citing works
Osborn, D., Limburg, H., Walters, K. R., Petersen, I., King, M., Green, J., Watson, J. R., & Nazareth, I. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.11.009 · Cited by 54 · see citing works
Cardiovascular adverse effects of newer antidepressants
Mago, R., Tripathi, N., & Andrade, C. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2014.908709 · Cited by 54 · see citing works
Schizophrenia, antipsychotics and risk of hip fracture: A population-based analysis
Sørensen, H. J., Jensen, S. O. W., & Nielsen, J. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.04.002 · Cited by 54 · see citing works
Fracture Risk in Nursing Home Residents Initiating Antipsychotic Medications
Rigler, S. K., Shireman, T. I., Cook‐Wiens, G., Ellerbeck, E. F., Whittle, J., Mehr, D. R., & Mahnken, J. D. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12216 · Cited by 53 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Andersohn F, Schade R, Suissa S et al. Long-term use of antide- pressants for depressive disorders and the risk of diabetes melli- tus. Am J Psychiatry 2009;166:591-8.
Cited by
Sorted by citations
Correll, C. U., Solmi, M., Veronese, N., Bortolato, B., Rosson, S., Santonastaso, P., Thapa‐Chhetri, N., Fornaro, M., Gallicchio, D., Collantoni, E., et al. (2017) · World Psychiatry · doi:10.1002/wps.20420 · Cited by 1,729 · see citing works
Self-citationVancampfort, D., Stubbs, B., Mitchell, A. J., De Hert, M., Wampers, M., Ward, P. B., Rosenbaum, S., & Correll, C. U. (2015) · World Psychiatry · doi:10.1002/wps.20252 · Cited by 1,271 · see citing works
Self-citationLiu, N. H., Daumit, G. L., Dua, T., Aquila, R., Charlson, F., Cuijpers, P., Druss, B., Dudek, K., Freeman, M., Fujii, C., et al. (2017) · World Psychiatry · doi:10.1002/wps.20384 · Cited by 865 · see citing works
Stubbs, B., Vancampfort, D., Hallgren, M., Firth, J., Veronese, N., Solmi, M., Brand, S., Cordes, J., Malchow, B., Gerber, M., et al. (2018) · European Psychiatry · doi:10.1016/j.eurpsy.2018.07.004 · Cited by 697 · see citing works
Self-citationCarvalho, A. F., Sharma, M. S., Brunoni, A. R., Vieta, E., & Fava, G. A. (2016) · Psychotherapy and Psychosomatics · doi:10.1159/000447034 · Cited by 650 · see citing works
Vancampfort, D., Correll, C. U., Galling, B., Probst, M., De Hert, M., Ward, P. B., Rosenbaum, S., Gaughran, F., Lally, J., & Stubbs, B. (2016) · World Psychiatry · doi:10.1002/wps.20309 · Cited by 659 · see citing works
Self-citationSolmi, M., Murru, A., Pacchiarotti, I., Undurraga, J., Veronese, N., Fornaro, M., Stubbs, B., Monaco, F., Vieta, E., Seeman, M., et al. (2017) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s117321 · Cited by 438 · see citing works
Self-citationMaj, M., Stein, D. J., Parker, G., Zimmerman, M., Fava, G. A., De Hert, M., Demyttenaere, K., McIntyre, R. S., Widiger, T., & Wittchen, H. (2020) · World Psychiatry · doi:10.1002/wps.20771 · Cited by 435 · see citing works
Self-citationCardiovascular disease in patients with severe mental illness
Nielsen, R. E., Banner, J., & Jensen, S. E. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00463-7 · Cited by 389 · see citing works
What is the risk‐benefit ratio of long‐term antipsychotic treatment in people with schizophrenia?
Correll, C. U., Rubio, J. M., & Kane, J. M. (2018) · World Psychiatry · doi:10.1002/wps.20516 · Cited by 324 · see citing works
Self-citationMaj, M., van Os, J., De Hert, M., Gaebel, W., Galderisi, S., Green, M. F., Guloksuz, S., Harvey, P. D., Jones, P. B., Malaspina, D., et al. (2021) · World Psychiatry · doi:10.1002/wps.20809 · Cited by 285 · see citing works
Self-citationBipolar depression: a major unsolved challenge
Baldessarini, R. J., Vázquez, G. H., & Tondo, L. (2020) · International Journal of Bipolar Disorders · doi:10.1186/s40345-019-0160-1 · Cited by 235 · see citing works
Vancampfort, D., Rosenbaum, S., Schuch, F. B., Ward, P. B., Probst, M., & Stubbs, B. (2016) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2015.11.008 · Cited by 225 · see citing works
Vancampfort, D., Firth, J., Correll, C. U., Solmi, M., Siskind, D., De Hert, M., Carney, R., Koyanagi, A., Carvalho, A. F., Gaughran, F., et al. (2019) · World Psychiatry · doi:10.1002/wps.20614 · Cited by 227 · see citing works
Self-citationSpeyer, H., Christian Brix Nørgaard, H., Birk, M., Karlsen, M., Storch Jakobsen, A., Pedersen, K., Hjorthøj, C., Pisinger, C., Gluud, C., Mors, O., et al. (2016) · World Psychiatry · doi:10.1002/wps.20318 · Cited by 153 · see citing works
Vermeulen, J., van Rooijen, G., Doedens, P., Numminen, E., van Tricht, M., & de Haan, L. (2017) · Psychological Medicine · doi:10.1017/s0033291717000873 · Cited by 134 · see citing works
Dragioti, E., Radua, J., Solmi, M., Gosling, C. J., Oliver, D., Lascialfari, F., Ahmed, M., Cortese, S., Estradé, A., Arrondo, G., et al. (2023) · World Psychiatry · doi:10.1002/wps.21068 · Cited by 130 · see citing works
Self-citationSalazar de Pablo, G., De Micheli, A., Nieman, D. H., Correll, C. U., Kessing, L. V., Pfennig, A., Bechdolf, A., Borgwardt, S., Arango, C., van Amelsvoort, T., et al. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.10.007 · Cited by 104 · see citing works
Self-citationRobinson, D. J., Hanson, K., Jain, A. B., Kichler, J. C., Mehta, G., Melamed, O. C., Vallis, M., Bajaj, H. S., Barnes, T., Gilbert, J., et al. (2023) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2023.04.009 · Cited by 73 · see citing works
Svensson, C. K., Larsen, J. R., Vedtofte, L., Jakobsen, M. S. L., Jespersen, H. R., Jakobsen, M. I., Koyuncu, K., Schjerning, O., Nielsen, J., Ekstrøm, C. T., et al. (2019) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12982 · Cited by 66 · see citing works
Self-citationStopping and switching antipsychotic drugs
Keks, N., Schwartz, D., & Hope, J. (2019) · Australian Prescriber · doi:10.18773/austprescr.2019.052 · Cited by 63 · see citing works
Croatto, G., Vancampfort, D., Miola, A., Olivola, M., Fiedorowicz, J. G., Firth, J., Alexinschi, O., Gaina, M. A., Makkai, V., Soares, F. C., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-022-01770-w · Cited by 66 · see citing works
Self-citationKahl, K. G., Stapel, B., & Frieling, H. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.09.004 · Cited by 47 · see citing works
Elie, D., Marino, A., Torres-Platas, S. G., Noohi, S., Semeniuk, T., Segal, M., Looper, K. J., & Rej, S. (2018) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2017.09.018 · Cited by 44 · see citing works
Capuzzi, E., Bartoli, F., Crocamo, C., Malerba, M. R., Clerici, M., & Carrà, G. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.10.050 · Cited by 42 · see citing works
Lambert, M., Ruppelt, F., Siem, A.-K., Rohenkohl, A. C., Kraft, V., Luedecke, D., Sengutta, M., Schröter, R., Daubmann, A., Correll, C. U., et al. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2017.07.036 · Cited by 29 · see citing works
Walburg, F. S., van Meijel, B., Hoekstra, T., Kol, J., Pape, L. M., de Joode, J. W., van Tulder, M., & Adriaanse, M. (2023) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2023.1566 · Cited by 27 · see citing works
Eriksson, R., Broberg, B. V., Ishøy, P. L., Bak, N., Andersen, U. B., Jørgensen, N. R., Knop, F. K., & Ebdrup, B. H. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00781 · Cited by 26 · see citing works
Tham, M., Chong, T. W. H., Jenkins, Z. M., & Castle, D. J. (2021) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2020.11.002 · Cited by 15 · see citing works
Medical Complications of Psychiatric Treatment
Lahijani, S. C., & Harris, K. A. (2017) · Critical Care Clinics · doi:10.1016/j.ccc.2017.03.008 · Cited by 8 · see citing works
Rivas, J., Miranda, C., Restrepo, A., Hernández, M., Erazo, J. M., Martínez, M. J., Lasso, J., López, L., & Gómez-Mesa, J. E. (2025) · Actas Españolas de Psiquiatría · doi:10.62641/aep.v53i4.1904 · Cited by 2 · see citing works
- Authors
- Correll, C. U., Detraux, J., De Lepeleire, J., & De Hert, M.
- Affiliations
- Albert Einstein College of Medicine (US)
- KU Leuven (BE)
- Department of Public Health and Primary Care; University of Leuven; B-3000 Leuven Belgium
- Department of Neurosciences; Catholic University Leuven; B-3070 Kortenberg Belgium
- Venue
- World Psychiatry
- Publisher
- Wiley
- Published
- 2015-06
- Volume
- 14
- Issue
- 2
- Pages
- 119-136
- ISSN
- 1723-8617 (ISSN-L)
- PMC
- PMC4471960
- OpenAlex
- W1603664273
- Cited by
- 820
- References
- 286
- Citations by year
- 2026: 59 · 2025: 79 · 2024: 77 · 2023: 75 · 2022: 71 · 2021: 77 · 2020: 89 · 2019: 88 · 2018: 71 · 2017: 66 · 2016: 51 · 2015: 15 · 2013: 1
- FWCI
- 54.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- World Psychiatry (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- antipsychotic drugs, antidepressants, mood stabilizers, somatic comorbidity, physical morbidity, schizophrenia, major depressive disorder, bipolar disorder, obesity, dyslipidemia, diabetes mellitus, thyroid dysfunction, hyponatremia, cardiovascular disease, polypharmacy, drug dosing, adverse drug reactions, severe mental illness, excess mortality
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
