The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
The efficacy of initial hydrocortisone administration at preventing posttraumatic distress in adult trauma patients: a randomized trial
Open accessAbstract
UNLABELLED: OBJECTIVE/INTRODUCTION: Secondary pharmacological interventions have shown promise at reducing the development of posttraumatic stress disorder symptoms (PTSS) in preclinical studies. The present study examined the preliminary efficacy of a 10-day low-dose (20 mg bid) course of hydrocortisone at preventing PTSS in traumatic injury victims. METHODS: Sixty-four traumatic injury patients (34% female) were randomly assigned in a double-blind protocol to receive either a 10-day course of hydrocortisone or placebo initiated within 12 hours of the trauma. One-month and 3-months posttrauma participants completed an interview to assess PTSS and self-report measures of depression and health-related quality of life. RESULTS: Hydrocortisone recipients reported fewer PTSD and depression symptoms, and had greater improvements in health-related quality of life during the first 3 months posttrauma than did placebo recipients. Hydrocortisone recipients who had never received prior mental health treatment had the lowest PTSD scores. CONCLUSION: Low-dose hydrocortisone may be a promising approach to the prevention of PTSD in acutely injured trauma patients, and may be particularly efficacious in acutely injured trauma victims without a history of significant psychopathology.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Similarly, in another recent report of 64 traumatic injury patients it was demonstrated that those who received a 10-day course of low dose oral hydrocortisone started within 12 hours of the injury reported fewer PTSD and depression symptoms at 1 and 3 months post-trauma follow-up than those who were treated with placebo [16].”
From Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial (2014) · cites this paper as [16]
In the citing paper
“All previous findings of effective PTSD prevention were observed in participants with increased risk for PTSD [i.e., caused by perceived life-threat (3), peritraumatic dissociation (4), or subthreshold acute stress disorder (5,6)].”
From Intranasal Oxytocin to Prevent Posttraumatic Stress Disorder Symptoms: A Randomized Controlled Trial in Emergency Department Patients (2017) · cites this paper as [4]
In the citing paper
“Previously, hydrocortisone (4,5) and prolonged exposure (3) initiated within 12 hours posttrauma in ED patients, and brief cognitive behavioral therapy within the first weeks posttrauma in patients with acute stress disorder (6), were found to reduce subsequent PTSD symptom severity.”
From Intranasal Oxytocin to Prevent Posttraumatic Stress Disorder Symptoms: A Randomized Controlled Trial in Emergency Department Patients (2017) · cites this paper as [4]
In the citing paper
“In addition, starting intranasal oxytocin treatments at the latest at day 10 post-trauma is considerably later than the timing of the only pharmacological intervention that has currently yielded promising preventive effects, i.e. hydrocortisone within the first 12 hours post-trauma [15,16].”
From Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial (2014) · cites this paper as [16]
In the citing paper
“Based on previous early intervention studies, recruiting ED patients for research purposes early after trauma exposures is feasible [10,15,16,60,98].”
From Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial (2014) · cites this paper as [16]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267
(1992) · PubMed · Cited by 33,716
The MOS 36-ltem Short-Form Health Survey (SF-36): I. Conceptual Framework and Item Selection
Ware, J. E., & Sherbourne, C. D. (1992) · Medical Care · doi:10.1097/00005650-199206000-00002 · Cited by 30,033
ASSESSMENT OF COMA AND IMPAIRED CONSCIOUSNESS
Teasdale, G., & Jennett, B. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91639-0 · Cited by 13,215
Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.617 · Cited by 12,052 · cited 10×
“16, and a significant main effect of drug group, F(1,36) 5 4.”
BackgroundMethodInfluentialThe development of a Clinician-Administered PTSD Scale
Blake, D. D., Weathers, F. W., Nagy, L. M., Kaloupek, D. G., Gusman, F. D., Charney, D. S., & Keane, T. M. (1995) · Journal of Traumatic Stress · doi:10.1002/jts.2490080106 · Cited by 5,024
Predictors of posttraumatic stress disorder and symptoms in adults: a meta-analysis
Ozer, E. J., Best, S. R., Lipsey, T. L., & Weiss, D. S. (2003) · Psychological Bulletin · doi:10.1037/0033-2909.129.1.52 · Cited by 3,322
THE MOS 36- ITEM SHORT FORM HEALTH SURVEY (SF- 36) CONCEPTUAL FRAMEWORK AND ITEM SELECTION
J.E.Jr., W., & Sherburne, C. D. (1992) · Cited by 1,586
Predictors of posttraumatic stress disorder and symptoms in adults: A meta-analysis.
Ozer, E. J., Best, S. R., Lipsey, T. L., & Weiss, D. S. (2008) · Psychological Trauma Theory Research Practice and Policy · doi:10.1037/1942-9681.s.1.3 · Cited by 1,252
Glucocorticosteroid Therapy: Mechanisms of Action and Clinical Considerations
FAUCI, A. S., DALE, D. C., & BALOW, J. E. (1976) · Annals of Internal Medicine · doi:10.7326/0003-4819-84-3-304 · Cited by 1,044
Research works printed but not linked: 2
- Marmar, 1997, Assessing Psychological Trauma PTSD, 412
- 10.1016/0024-3205(96)00118-X · DOI
Cited by
Sorted by citations
Post-traumatic stress disorder.
Yehuda, R., Hoge, C. W., McFarlane, A. C., Vermetten, E., Lanius, R. A., Nievergelt, C. M., Hobfoll, S. E., Koenen, K. C., Neylan, T. C., & Hyman, S. E. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.57 · Cited by 870
Stress, glucocorticoids and memory: implications for treating fear-related disorders
de Quervain, D., Schwabe, L., & Roozendaal, B. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.155 · Cited by 484
Myers, B., McKlveen, J. M., & Herman, J. P. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.12.003 · Cited by 318
“Further, stress-level doses of hydrocortisone reduce PTSD symptomtology in patients following traumatic experience (Aerni et al., 2004; Delahanty et al., 2013; Schelling et al., 2003, 2001, 1999; Weis et al., 2006; Zohar et al., 2011).”
BackgroundMobile mental health: a challenging research agenda
Olff, M. (2015) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v6.27882 · Cited by 258
“…is still little consensus on how to deliver effective early inter- ventions and how to reach all people in need of these interventions in time although recent new exposure-based (Rothbaum et al., 2012) and medication-based (Delahanty et al., 2013; Frijling et al., 2012) approaches show promise.”
BackgroundThe Biology of Human Resilience: Opportunities for Enhancing Resilience Across the Life Span
Feder, A., Fred-Torres, S., Southwick, S. M., & Charney, D. S. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.07.012 · Cited by 269
The hypothalamic-pituitary-adrenal axis in PTSD: Pathophysiology and treatment interventions
Dunlop, B. W., & Wong, A. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.10.010 · Cited by 271
“A larger placebo-controlled study of 64 traumatically injured patients found that 10 days of oral hydrocortisone administered as 20 mg twice daily (followed by a six-day taper) that was started within 12 h of the traumatic event resulted in lower PTSD symptoms at three months' follow-up (Delahanty et al., 2013).”
BackgroundPrevention of Post-Traumatic Stress Disorder After Trauma: Current Evidence and Future Directions
Qi, W., Gevonden, M. J., & Shalev, A. Y. (2016) · Current Psychiatry Reports · doi:10.1007/s11920-015-0655-0 · Cited by 209
The role of the immune system in posttraumatic stress disorder
Katrinli, Ş., Oliveira, N. C. D. S., Felger, J. C., Michopoulos, V., & Smith, A. K. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02094-7 · Cited by 201
Steudte‐Schmiedgen, S., Kirschbaum, C., Alexander, N., & Stalder, T. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.015 · Cited by 177
“The latter evidence also concurs with findings that hydrocortisone treatment improves the trajectory of PTSD when given in the aftermath of trauma (Delahanty et al., 2013; Schelling et al., 2004; Zohar et al., 2011) and ameliorates PTSD symptoms in affected patients (Aerni et al., 2004; de…”
ResultUnderstanding Resilience and Preventing and Treating PTSD
Horn, S. R. G.-V., & Feder, A. (2018) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000194 · Cited by 162
Sijbrandij, M., Kleiboer, A., Bisson, J. I., Barbui, C., & Cuijpers, P. (2015) · The Lancet Psychiatry · doi:10.1016/s2215-0366(14)00121-7 · Cited by 136
van Zuiden, M., Frijling, J. L., Nawijn, L., Koch, S. B. J., Goslings, J. C., Luitse, J. S., Biesheuvel, T. H., Honig, A., Veltman, D. J., & Olff, M. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.11.012 · Cited by 134
Wright, L. A., Sijbrandij, M., Sinnerton, R. J. H., Lewis, C., Roberts, N. P., & Bisson, J. I. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0673-5 · Cited by 144
Prevention of trauma and stressor-related disorders: A review
Howlett, J. R., & Stein, M. B. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.261 · Cited by 102
“In another trial, 64 traumatic injury patients received a 10-day course of low-dose hydrocortisone or placebo initiated within 12 h of trauma, and those receiving hydrocortisone had lower PTSD symptoms at 3 months (Delahanty et al, 2013).”
BackgroundThe Current Evidence for Acute Stress Disorder
Bryant, R. A. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0976-x · Cited by 114
Astill Wright, L., Horstmann, L., Holmes, E. A., & Bisson, J. I. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01570-w · Cited by 97
Preventing the onset of post traumatic stress disorder
Bisson, J. I., Wright, L. A., Jones, K. A., Lewis, C., Phelps, A. J., Sijbrandij, M., Varker, T., & Roberts, N. P. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2021.102004 · Cited by 85
Frijling, J. L. (2017) · European Journal of Psychotraumatology · doi:10.1080/20008198.2017.1302652 · Cited by 94
Feld, G. B., & Jan Born, A. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0490-9 · Cited by 84
Glucocorticoid-induced enhancement of extinction—from animal models to clinical trials
de Quervain, D. J. ‐., Wolf, O. T., & Roozendaal, B. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5116-0 · Cited by 82
A Public Health Perspective of Post-Traumatic Stress Disorder
Jowf, G. I. A., Ahmed, Z. T., An, N., Reijnders, R. A., Ambrosino, E., Rutten, B. P. F., de Nijs, L., & Eijssen, L. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19116474 · Cited by 93
Intensive Care Unit Delirium and Intensive Care Unit–Related Posttraumatic Stress Disorder
Marra, A., Pandharipande, P. P., & Patel, M. B. (2017) · Surgical Clinics of North America · doi:10.1016/j.suc.2017.07.008 · Cited by 78
Pharmacological interventions for preventing post-traumatic stress disorder (PTSD)
Amos, T., Stein, D. J., & Ipser, J. C. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006239.pub2 · Cited by 169
(2018) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.16408 · Cited by 77
An Evidence-Based Review of Early Intervention and Prevention of Posttraumatic Stress Disorder
Birur, B., Moore, N. C., & Davis, L. L. (2016) · Community Mental Health Journal · doi:10.1007/s10597-016-0047-x · Cited by 69
“Compared to placebo, those in the hydrocortisone group reported less PTSD, less depression, and greater improvements in quality of life at 1- and 3-months post-trauma (Delahanty et al. 2013).”
BackgroundFrijling, J. L., van Zuiden, M., Koch, S. B. J., Nawijn, L., Veltman, D. J., & Olff, M. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv116 · Cited by 62
Biomarkers of PTSD: military applications and considerations
Lehrner, A. L., & Yehuda, R. (2014) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v5.23797 · Cited by 65
Neurobiology and Treatment of Posttraumatic Stress Disorder
Shalev, A. Y., Cho, D., & Marmar, C. R. (2024) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20240536 · Cited by 67
Frijling, J. L., van Zuiden, M., Koch, S. B., Nawijn, L., Goslings, J. C., Luitse, J. S., Biesheuvel, T. H., Honig, A., Bakker, F. C., Denys, D., et al. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-92 · Cited by 59
“hydrocortisone within the first 12 hours post-trauma [15,16].”
BackgroundResultHauer, D., Kaufmann, I., Strewe, C., Briegel, I., Campolongo, P., & Schelling, G. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.10.003 · Cited by 49
Estradiol modulation of the renin–angiotensin system and the regulation of fear extinction
Parrish, J. N., Bertholomey, M. L., Pang, H. W., Speth, R. C., & Torregrossa, M. M. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0374-0 · Cited by 51
Kothgassner, O. D., Pellegrini, M., Goreis, A., Giordano, V., Edobor, J., Fischer, S., Plener, P. L., & Huscsava, M. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105168 · Cited by 49
Cannabinoids as therapeutics for PTSD
Sbarski, B., & Akirav, I. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107551 · Cited by 47
Ploski, J. E., & Vaidya, V. A. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.04.009 · Cited by 46
Cortisol and the Hypothalamic–Pituitary–Adrenal Axis in PTSD
Lehrner, A. L., Daskalakis, N. P., & Yehuda, R. (2016) · Wiley eBooks · doi:10.1002/9781118356142.ch11 · Cited by 43
Hruska, B., Cullen, P. K., & Delahanty, D. L. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.02.001 · Cited by 38
Glucocorticoid-based pharmacotherapies preventing PTSD
Florido, A., Velasco, E. R., Monari, S., Cano, M., Cardoner, N., Sandi, C., Andero, R., & Pérez-Caballero, L. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109344 · Cited by 39
DePierro, J. M., Lepow, L., Feder, A., & Yehuda, R. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.07.009 · Cited by 41
“Based on the idea that lower cortisol levels at the time of trauma exposure might facilitate SNS hyperactivity and lead to intrusive, traumatic memories, this strategy of glucocorticoid administration during the “golden hours” following trauma was used to identify its role in PTSD prevention (51, 52).”
MethodRoberts, M., Glaspey, L. J., Mazzarelli, A. J., Jones, C. W., Kilgannon, H., Trzeciak, S., & Roberts, B. W. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003222 · Cited by 37
The Pathways between Cortisol-Related Regulation Genes and PTSD Psychotherapy
Castro-Vale, I., & Carvalho, D. M. (2020) · Healthcare · doi:10.3390/healthcare8040376 · Cited by 39
Adverse Childhood Experience, Genes, and PTSD Risk in Soldiers: A Methylation Study
Hossack, M., Reid, M., Aden, J. K., Gibbons, T. F., Noe, J. C., & Willis, A. M. (2019) · Military Medicine · doi:10.1093/milmed/usz292 · Cited by 36
Bertolini, F., Robertson, L., Bisson, J. I., Meader, N., Churchill, R. C., Ostuzzi, G., Stein, D. J., Williams, T., & Barbui, C. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013443.pub2 · Cited by 38
Prospects for the Pharmacological Prevention of Post-Traumatic Stress in Vulnerable Individuals
Ostrowski, S. A., & Delahanty, D. L. (2014) · CNS Drugs · doi:10.1007/s40263-014-0145-7 · Cited by 28
Mouthaan, J., Sijbrandij, M., Reitsma, J. B., Luitse, J. S. K., Goslings, J. C., Gersons, B. P. R., & Olff, M. (2015) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2015.02.010 · Cited by 26
“In humans, nonrandomized [31] and randomized [32–36] controlled trials have demonstrated that hydrocortisone administration after medical traumawas associated with a lower risk for PTSD symptom development.”
Novel pharmacological treatment strategies for posttraumatic stress disorder
Thomas, E., & Stein, D. J. (2016) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2017.1260001 · Cited by 24
Goodman, J., & Packard, M. G. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.05.007 · Cited by 24
Hadad, N. A., Schwendt, M., & Knackstedt, L. A. (2020) · Stress · doi:10.1080/10253890.2020.1803824 · Cited by 23
Effects of acute cortisol administration on perceptual priming of trauma-related material
Holz, E., Lass-Hennemann, J., Streb, M., Pfaltz, M., & Michael, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104864 · Cited by 22
“Delahanty and colleagues [34] showed that repeated cortisol administration (over 10 days) prevented PTSD in traumatic injury patients.”
BackgroundHeim, C. C. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.19111189 · Cited by 21
Roque, A. P. (2015) · Issues in Mental Health Nursing · doi:10.3109/01612840.2015.1057785 · Cited by 21
Impact of exogenous cortisol on the formation of intrusive memories in healthy women
Rombold, F., Wingenfeld, K., Renneberg, B., Schwarzkopf, F., Hellmann‐Regen, J., Otte, C., & Roepke, S. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.08.005 · Cited by 23
Pham, C. H., Fang, M., Nager, J., Matsushima, K., Inaba, K., & Kuza, C. M. (2019) · Journal of Trauma and Acute Care Surgery · doi:10.1097/ta.0000000000002371 · Cited by 18
“Delahanty et al.(38) administered a 10-day hydrocortisone course within 12 hours of injury to trauma patients.”
BackgroundInfluentialPharmacological Secondary Prevention of PTSD in Youth: Challenges and Opportunities for Advancement
Maccani, M. A., Delahanty, D. L., Nugent, N. R., & Berkowitz, S. J. (2012) · Journal of Traumatic Stress · doi:10.1002/jts.21731 · Cited by 20
“Similarly, a larger RCT examining the efficacy of a 10-day regimen of low-dose (20 mg, twice daily [bid]) hydrocortisone in seriously injured trauma patients found that hydrocortisone recipients reported significantly lower PTSD symptom severity at 1- and 3-month follow-up than placebo recipients (Delahanty et al., 20…”
BackgroundNeuroendocrinological treatment targets for posttraumatic stress disorder
Yoon, S., & Kim, Y. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.11.021 · Cited by 19
“Studies investigating the use of hydrocortisone for preventing PTSD were conducted during or right after various situations involving severe psychological and physical trauma, such as within 12 h after traumatic injury (Delahanty et al., 2013), within six hours after exposure to a traumatic event (e.”
Patient-reported outcomes in post-traumatic stress disorder Part I: Focus on psychological treatment
d'Ardenne, P., & Heke, S. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.2/sheke · Cited by 16
A Review of Psychopharmacological Interventions Post-Disaster to Prevent Psychiatric Sequelae
Birur, B., Math, S. B., & Fargason, R. E. (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4352 · Cited by 17
Graebener, A. H., Michael, T., Holz, E., & Lass-Hennemann, J. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.09.001 · Cited by 15
Recent Progress in Biosensors for Depression Monitoring—Advancing Personalized Treatment
Yin, J., Jia, X., Li, H., Zhao, B., Yang, Y. A., & Ren, T. (2024) · Biosensors · doi:10.3390/bios14090422 · Cited by 14
Schaffter, N., Ledermann, K., Pazhenkottil, A. P., Barth, J., Schnyder, U., Znoj, H., Schmid, J., Meister‐Langraf, R. E., von Känel, R., & Princip, M. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.05.065 · Cited by 17
“…that hydrocortisone given after a traumatic event reduces the risk for the development of PTSD in patients with septic shock (Schelling et al., 2001) and of PTSD symptoms in patients with traumatic injury (Delahanty et al., 2013) or cardiac surgery (Schelling et al., 2004; Weis et al., 2006).”
BackgroundEarly interventions for the prevention of PTSD in adults: a systematic literature review
LINARES, I. M. P., CORCHS, F. D. F., CHAGAS, M. H. N., ZUARDI, A. W., MARTIN-SANTOS, R., & CRIPPA, J. A. S. (2017) · Archives of Clinical Psychiatry (São Paulo) · doi:10.1590/0101-60830000000109 · Cited by 13
O’Shields, J., Patel, D., & Mowbray, O. P. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.05.077 · Cited by 15
“Indeed, some evidence for this approach has already been identified in the use of a 10-day course of hydrocortisone for adults within 12 h of experiencing physical trauma, which was associated with lower rates of future depressive symptoms compared to the placebo group (Delahanty et al., 2013).”
BackgroundKapfhammer, H. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.2/hkapfhammer · Cited by 13
Neuroendocrinology of Posttraumatic Stress Disorder
Bowers, M. E., & Yehuda, R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802175-0.00016-4 · Cited by 14
Management of Treatment-Resistant Posttraumatic Stress Disorder
Starke, J., & Stein, D. J. (2017) · Current Treatment Options in Psychiatry · doi:10.1007/s40501-017-0130-0 · Cited by 12
Cohen, H., Ephraim‐Oluwanuga, O. T., Orunmuyi, A. T., Gureje, O., Matar, M. A., Todder, D., & Zohar, J. (2023) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12311 · Cited by 10
Akute und posttraumatische Belastungsstörung
Kapfhammer, H. (2017) · Springer eBooks · doi:10.1007/978-3-662-49295-6_71 · Cited by 11
Luo, L., Chai, Y., Jiang, R., Chen, X., & Yan, T. (2015) · Aging and Disease · doi:10.14336/ad.2015.0507 · Cited by 12
“Based on the strong and evolving evidence from previous studies [44, 45], the treatment included anti-depression pharmacological interventions, psychotherapeutic interventions and Prednisone.”
BackgroundTheranostic pharmacology in PTSD: Neurobiology and timing
Koek, R. J., & Luong, T. N. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.12.001 · Cited by 10
Gillam, W. B., V, Godbole, N. B., Sangam, S., DeTommaso, A., Foreman, M. A., & Lucke-Wold, B. P. (2023) · Biomedicines · doi:10.3390/biomedicines11102732 · Cited by 9
“Furthermore, low-dose hydrocortisone injections may serve to prevent PTSD in neurotrauma patients [97].”
BackgroundEarly interventions: from e-health to neurobiology
Olff, M., van Zuiden, M., & Bakker, A. (2015) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v6.28545 · Cited by 9
“…early interventions, researchers have focused on finding new forms of potential early interventions using both pharmacological (e.g., hydrocortisone [Delahanty et al., 2013], morphine [Mouthaan et al., 2015] or oxytocin [Koch et al., 2014]) and psychological routes, such as inno- vative dyadic…”
BackgroundMusculoskeletal injury survivors’ resiliency: A systematic review
Moran, M. E., Hodgson, J. L., Jensen, J. F., & Wood, T. L. (2020) · Disability and health journal · doi:10.1016/j.dhjo.2020.100987 · Cited by 8
Psychologische Frühinterventionen
Bengel, J., Becker-Nehring, K., & Hillebrecht, J. (2019) · Springer eBooks · doi:10.1007/978-3-662-58470-5_10 · Cited by 9
Bertolini, F., Robertson, L., Bisson, J. I., Meader, N., Churchill, R. C., Ostuzzi, G., Stein, D. J., Williams, T., & Barbui, C. (2024) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013613.pub2 · Cited by 9
Rudzki, S. J. (2022) · Military Medicine · doi:10.1093/milmed/usac095 · Cited by 8
Pedraza, L. K., Sierra, R. O., & Alvares, L. D. O. (2022) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2022.2027010 · Cited by 6
“Thus, glucocorticoid(GRs)-based treatments are currently claimed as a therapeutic option for PTSD (Schelling et al. 2006; Golier et al. 2012, 2016; Delahanty et al. 2013).”
BackgroundPosttraumatic Stress Disorder (PTSD)
Brewin, C. R. (2012) · Oxford University Press eBooks · doi:10.1093/obo/9780199828340-0094 · Cited by 5
Pharmacological Treatment of Cognitive Dysfunction in Neuropsychiatric Disorders
Venero, C. (2015) · Cognitive Enhancement · doi:10.1016/b978-0-12-417042-1.00010-3 · Cited by 4
Obi, T., & Ressler, K. J. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02371-9 · Cited by 5
Vanderhoof, S. O., Vincent, C. J., Beaver, J. N., Latsko, M. S., Aguilar-Alvarez, R., & Jasnow, A. M. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06616-7 · Cited by 4
“Glucocorticoids have been used with some success in adults to reduce trauma-induced PTSD symptoms (Aerni et al. 2004; Delahanty et al. 2013; Hruska et al. 2014; Schelling et al. 2001, 2004; Suris et al. 2010).”
BackgroundEffects of acute pain medications on posttraumatic stress symptoms in early aftermath of trauma
Grau, A. S., Xie, H., Redfern, R. E., Moussa, M., Wang, X., & Shih, C.-H. (2022) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000413 · Cited by 4
A salience hypothesis of stress in PTSD
Chakraborty, P., Chattarji, S., & Jeanneteau, F. D. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15526 · Cited by 5
Post-traumatic Stress Disorder
Şahingöz, M., & Sarı, S. (2019) · Springer eBooks · doi:10.1007/978-3-319-92919-4_18 · Cited by 3
Prevention of PTSD in Children and Adolescents
Brymer, M. J., Louie, K. A., & Berkowitz, S. J. (2019) · Psychiatric Annals · doi:10.3928/00485713-20190603-01 · Cited by 3
Kern, D. M., Teneralli, R. E., Flores, C. M., Wittenberg, G. M., Gilbert, J. P., & Cepeda, M. S. (2021) · Psychiatric Research and Clinical Practice · doi:10.1176/appi.prcp.20210019 · Cited by 3
Early Psychological Interventions
Bengel, J., Becker-Nehring, K., & Hillebrecht, J. (2022) · Springer eBooks · doi:10.1007/978-3-662-64057-9_10 · Cited by 2
POST-TRAUMATIC STRESS DISORDER AS PRESSING ISSUES OF OUR TIME
Mohylnyk, A., Zhyvotovska, L. V., Tarasenko, K. V., Boiko, D. I., Sonnik, Y., & Arkhipovets, O. (2023) · Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії · doi:10.31718/2077-1096.23.3.203 · Cited by 3
“Серед експериментальних методів фармакопрофілактики розвитку ПТСР в гостро-му стресовому періоді можна згадати β-блокатори [37], сертралін [38], есциталопрам [39], гідрокортизон [40], кетамін [41], габапентин [42] та окситоцин [43].”
Pharmacological Prevention of Posttraumatic Stress Disorder: A Systematic Review
Rajkumar, R. P., & Bharadwaj, B. (2014) · Advances in Psychiatry · doi:10.1155/2014/529562 · Cited by 2
“Four studies [35–38] assessed the use of hydrocortisone in preventing PTSD.”
BackgroundResultInfluentialEarly pharmacological interventions for acute traumatic stress symptoms: a network meta-analysis
Bertolini, F., Robertson, L., Ostuzzi, G., Meader, N., Bisson, J. I., Churchill, R. C., & Barbui, C. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013613 · Cited by 2
Rabinowitz, E. P., Sayer, M. A., Samii, M. R., Straub, E. L., Kutash, L. A., & Delahanty, D. L. (2021) · Stress and Health · doi:10.1002/smi.3117 · Cited by 2
Posttraumatic stress disorder: An overview in new diagnosis and treatment approaches
Pejušković, B. (2024) · Medicinska istrazivanja · doi:10.5937/medi57-44935 · Cited by 1
Stress, stress systems, and Alzheimer's disease
Eberly, S. G., Phumsatitpong, C., Munro, C. E., Neylan, T. C., Kaufer, D., & Ehrenberg, A. J. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71542 · Cited by 1
Primary prevention and epidemiology of trauma- and stress-related disorders
Bragesjö, M., Holmes, E. A., Arnberg, F. K., & Andersson, E. M. (2020) · doi:10.1093/med/9780198713005.003.0082 · Cited by 1
Trauma- and Stressor-Related Disorders
Sherrill, A. M., & Rauch, S. A. M. (2018) · Cambridge University Press eBooks · doi:10.1017/9781108140416.031 · Cited by 1
Bertolini, F., Robertson, L., Ostuzzi, G., Meader, N., Bisson, J. I., Churchill, R. C., & Barbui, C. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013443 · Cited by 1
“The trials testing steroids for PTSD prevention have used either single dose administration or a course of a few days in individuals with severe physical conditions (Delahanty 2013; Schelling 2001; Weis 2006).”
BackgroundStörungsspezifische Versorgung
Pajonk, F., Messer, T., & Berzewski, H. (2020) · Springer eBooks · doi:10.1007/978-3-662-61174-6_6 · Cited by 1
Consequences of rape : injuries, posttraumatic stress and neuroendocrinological changes
Möller, A. T. (2015) · Figshare · Cited by 1
Boukef, R., Youssef, R., Yaakoubi, H., Trabelsi, I., Sekma, A., Ali, K. B. H., Salah, H. B., Baccari, A., Boukadida, L., & Zorgati, A. (2022) · medRxiv · doi:10.1101/2022.01.12.22268879 · Cited by 1
“This study suggests that early treatment with low dose hydrocortisone low may be effective in preventing PTSD [35].”
BackgroundŞahingöz, M., & Sarı, S. (2025) · Springer eBooks · doi:10.1007/978-3-031-99720-4_20 · Cited by 1
A Mechanistic Model for the HPA Axis Cortisol Paradox in PTSDPreprint
Danan, D., Grosskopf, Y., Hayut, Y., Toledano, Y., Doenyas‐Barak, K., Mayo, A., & Alon, U. S. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.13.681561 · Cited by 1
Lawford‐Smith, H. (2015)
Metadata
- Authors
- Delahanty, D. L., Gabert-Quillen, C., Ostrowski, S. A., Nugent, N. R., Fischer, B., Morris, A., Pitman, R. K., Bon, J., & Fallon, W.
- Affiliations
- Kent State University (US)
- Akron Children's Hospital (US)
- Harvard University (US)
- Summa Health System (US)
- Corresponding author
- Delahanty, Douglas L.
- Venue
- CNS Spectrums
- Publisher
- Cambridge University Press (CUP)
- Published
- 2013-04
- Volume
- 18
- Issue
- 2
- Pages
- 103-111
- ISSN
- 1092-8529 (ISSN-L)
- 2165-6509
- PMC
- PMC5981864
- OpenAlex
- W2165080151
- Cited by
- 115
- References
- 60
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 6 · 2023: 6 · 2022: 11 · 2021: 9 · 2020: 8 · 2019: 12 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 13 · 2014: 10 · 2013: 2
- FWCI
- 12.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- CNS Spectrums (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (K01MH087240, R34MH073014)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Keywords
- cortisol, post-traumatic stress disorder, PTSD prevention, trauma patients, low-dose corticosteroids, depression, health-related quality of life, acute injuries
- MeSH terms
- Adult, Double-Blind Method, Female, Humans, Hydrocortisone, Male, Middle Aged, Risk Factors, Stress Disorders, Post-Traumatic, Anti-Anxiety Agents, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
