White Matter Integrity Dissociates Verbal Memory and Auditory Attention Span in Emerging Adults with Congenital Heart Disease
Abstract
White matter disruptions have been identified in individuals with congenital heart disease (CHD). However, no specific theory-driven relationships between microstructural white matter disruptions and cognition have been established in CHD. We conducted a two-part study. First, we identified significant differences in fractional anisotropy (FA) of emerging adults with CHD using Tract-Based Spatial Statistics (TBSS). TBSS analyses between 22 participants with CHD and 18 demographically similar controls identified five regions of normal appearing white matter with significantly lower FA in CHD, and two higher. Next, two regions of lower FA in CHD were selected to examine theory-driven differential relationships with cognition: voxels along the left uncinate fasciculus (UF; a tract theorized to contribute to verbal memory) and voxels along the right middle cerebellar peduncle (MCP; a tract previously linked to attention). In CHD, a significant positive correlation between UF FA and memory was found,r(20)=.42,p=.049 (uncorrected). There was no correlation between UF and auditory attention span. A positive correlation between MCP FA and auditory attention span was found,r(20)=.47,p=.027 (uncorrected). There was no correlation between MCP and memory. In controls, no significant relationships were identified. These results are consistent with previous literature demonstrating lower FA in younger CHD samples, and provide novel evidence for disrupted white matter integrity in emerging adults with CHD. Furthermore, a correlational double dissociation established distinct white matter circuitry (UF and MCP) and differential cognitive correlates (memory and attention span, respectively) in young adults with CHD. (JINS, 2015,21, 22–33)
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Both adolescents and adults who had surgery for congenital heart disease show altered functional activity during working memory tests compared with controls.
“Both adolescents and adults who underwent surgery for CHD displayed altered functional activity during working memory tests compared with controls.67,68”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [68]
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- Authors
- Brewster, R. C., King, T. Z., Burns, T. G., Drossner, D. M., & Mahle, W. T.
- Affiliations
- Georgia State University (US)
- Emory University (US)
- Children's Healthcare of Atlanta (US)
- Corresponding author
- King, Tricia Z.
- Venue
- Journal of the International Neuropsychological Society
- Publisher
- Cambridge University Press (CUP)
- Published
- 2015-01
- Volume
- 21
- Issue
- 1
- Pages
- 22-33
- ISSN
- 1355-6177 (ISSN-L)
- 1469-7661
- OpenAlex
- W2102122500
- Cited by
- 48
- References
- 76
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 7 · 2022: 14 · 2021: 3 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 1
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the International Neuropsychological Society (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Cancer Society
- Georgia State University
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- congenital heart disease, white matter integrity, fractional anisotropy, verbal memory, uncinate fasciculus, middle cerebellar peduncle, emerging adults, cognitive function, double dissociation, white matter microstructure
- MeSH terms
- Acoustic Stimulation, Adolescent, Attention Deficit Disorder with Hyperactivity, Cognition Disorders, Female, Heart Defects, Congenital, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory Disorders, Neuropsychological Tests, Statistics as Topic, Verbal Learning, Young Adult, Middle Cerebellar Peduncle, White Matter
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