fMRI investigation of working memory in adolescents with surgically treated congenital heart disease
Abstract
Adolescents and young adults with surgically treated congenital heart disease (CHD) have been shown to exhibit difficulties with executive functions; however, the neural underpinnings of these impairments have not been previously examined with functional magnetic resonance imaging (fMRI). The current study employed fMRI to examine the neural mechanisms during a letter n-back task of working memory compared to vigilance. Seventeen participants with CHD (Mage = 17.76 ± 1.72 years; 88% Caucasian; 30% female; mean IQ = 104.12 ± 15.15) were compared to 17 controls (Mage = 18.40 ± 1.74 years; 70% Caucasian; 30% female; mean IQ = 110.59 ± 5.28) with similar declining performance as the n-back became more challenging. Overall, both groups activated similar frontal-parietal working-memory networks as seen in previous literature; however, some significant differences were detected between the groups. Specifically, the participants with CHD demonstrated differences within the left precuneus and the right inferior frontal gyrus. Secondary analyses indicated that this difference appeared to be due to less task-induced deactivation (TID) in the CHD group during working memory and greater working-memory TID in the control group. In CHD, prefrontal fMRI deactivation on working-memory tasks correlated with improved working-memory performance. Future complementary neuroimaging research with functional connectivity is warranted to further examine the neural underpinnings of disrupted executive function in the long-term outcomes of CHD.
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Both adolescents and adults who had surgery for congenital heart disease show altered functional activity during working memory tests compared with controls.
“Both adolescents and adults who underwent surgery for CHD displayed altered functional activity during working memory tests compared with controls.67,68”
From Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease (2017) · cites this paper as [67]
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- Authors
- King, T. Z., Smith, K. M., Burns, T. G., Sun, B., Shin, J., Jones, R. A., Drossner, D., & Mahle, W. T.
- Affiliations
- Georgia Institute of Technology (US)
- Georgia State University (US)
- Children's Healthcare of Atlanta (US)
- Emory University (US)
- Corresponding author
- King, Tricia Z.
- Venue
- Applied Neuropsychology: Child
- Publisher
- Informa UK Limited
- Published
- 2016-03-17
- Volume
- 6
- Issue
- 1
- Pages
- 7-21
- ISSN
- 2162-2965 (ISSN-L)
- 2162-2973
- OpenAlex
- W2320528219
- Cited by
- 25
- References
- 47
- Citations by year
- 2024: 1 · 2023: 4 · 2022: 7 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 2
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Applied Neuropsychology Child (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Keywords
- congenital heart disease, working memory, adolescents, executive function, task-induced deactivation, precuneus, inferior frontal gyrus, frontoparietal network, sustained attention
- MeSH terms
- Adolescent, Adolescent Behavior, Female, Heart Defects, Congenital, Humans, Magnetic Resonance Imaging, Male, Memory, Short-Term, Photic Stimulation, Psychomotor Performance, Cohort Studies, Treatment Outcome, Young Adult
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