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Cited by 363Nutritional Studies and DietPhytochemicals and Antioxidant ActivitiesGlobal Cancer Incidence and Screening

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Fruits and vegetables in the prevention of cancer and cardiovascular disease

Open access
van't Veer, Pieter, Jansen, Margje CJF, Klerk, Mariska, Kok, Frans J·2000·Public Health Nutrition
DOI 10.1017/s1368980000000136
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Abstract

OBJECTIVE: We quantified the public health benefit of fruits and vegetables on the prevention of cancer and cardiovascular disease (CVD), using currently available human data. DESIGN: We reviewed over 250 observational studies on cancer and CVD. Relative risks (RRs) for high versus low intake of fruits and vegetables were obtained. The preventable proportion of chronic diseases, i.e. the per cent of cases attributable to low consumption of fruits and vegetables, was estimated using three scenarios: best guess, optimistic (using stronger RRs) and conservative (using weaker RRs and eliminating the contribution of smoking and/or drinking). The preventable proportion was calculated for increasing average intake from the current 250 g day(-1) to the recommended 400 g day(-1) among the general Dutch population. RESULTS: It is estimated that in the Netherlands cancer incidence could be reduced by 19% (12,000 cases annually, best guess), ranging from 6% (conservative) to 28% (optimistic). Cardiovascular deaths could be reduced by 16% (8000 deaths annually, best guess), ranging from 6% to 22%. Evidence is most abundant for gastrointestinal cancers, followed by hormone-related cancers, but limited for other sites and CVD. CONCLUSIONS: Increasing consumption of fruits and vegetables carries a large public health potential. Population trials and biological mechanisms should eventually provide scientific proof of their efficacy. The available evidence is sufficient to justify public health education and promotion aimed at a substantial increase in the consumption of fruits and vegetables.

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Research works printed but not linked: 3

  1. Tomatis, 1990, Cancer: Causes, Occurences and Control
  2. Kistemake, 1993, De Consumptie Van Groepen Voedingsmiddelen door Nederlandse Bevolkingsgroepen
  3. 3 Margetts BM , Thompson R , Duffy S on behalf of the Nutritional Epidemiology Working Group on Diet and Cancer. A Review of the Epidemiological Literature Linking Fruit and Vegetable Consumption to Risk of Cancer 1994.

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Metadata

Authors
van't Veer, P., Jansen, M. C., Klerk, M., & Kok, F. J.
Affiliations
  • National Institute for Public Health and the Environment (NL)
  • Wageningen University & Research (NL)
ORCID
Kok, Frans J
Venue
Public Health Nutrition
Publisher
Cambridge University Press (CUP)
Published
2000-03
Volume
3
Issue
1
Pages
103-107
ISSN
  • 1368-9800 (ISSN-L)
  • 1475-2727
DOI
10.1017/s1368980000000136
OpenAlex
W2170476987
Cited by
362
References
9
Citations by year
2026: 7 · 2025: 7 · 2024: 4 · 2023: 10 · 2022: 7 · 2021: 11 · 2020: 14 · 2019: 14 · 2018: 12 · 2017: 14 · 2016: 17 · 2015: 23 · 2014: 17 · 2013: 36 · 2012: 23
FWCI
12.50
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified, 2498 d)
Locations
  • Public Health Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Rivm Repository (Netherlands National Institute for Public Health and the Environment) (submittedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
  • Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
Keywords
fruits and vegetables, cancer prevention, cardiovascular disease, dietary intake, relative risk, gastrointestinal cancer, hormone-dependent tumors, cardiovascular mortality, public health benefits, dietary recommendations, Netherlands
MeSH terms
Cardiovascular Diseases, Diet, Fruit, Humans, Neoplasms, Netherlands, Public Health, Risk Factors, Vegetables

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