Desipramine treatment reduces the long-term behavioural and neurochemical sequelae of early-life maternal separation
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Primate and rodent models of maternal separation have shown that repeated postnatal separation of young from the mother results in long-term changes to neurohormonal systems relevant to depression. To date, however, it remains unclear whether rodents that experience postnatal maternal separation display specific behavioural or biochemical features of depression in adulthood and whether these changes can be prevented by treatment with antidepressant drugs. We report here that maternally separated mice showed significantly shorter swim times on the forced swim test and significantly lower levels of brain-derived neurotrophic factor in dentate gyrus and CA3 regions of the hippocampus compared to control mice when assessed in adulthood. Neither of these differences was apparent in maternally separated mice that received chronic treatment with the antidepressant desipramine after maternal separation. These results suggest that intervention following early stress may eliminate the long-term vulnerability to behavioural and biochemical dysfunction that occurs following this early chronic stress.
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Reciprocal interactions between BDNF and serotonin have been well documented.
“Reciprocal interactions between BDNF and serotonin have also been well documented (Duman 2002; MacQueen et al. 2003).”
From Gene–environment interactions: early life stress and risk for depressive and anxiety disorders (2011) · cites this paper as MacQueen et al. 2003
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- Authors
- MacQueen, G. M., Ramakrishnan, K., Ratnasingan, R., Chen, B., & Young, L. T.
- Affiliations
- McMaster University (CA)
- Corresponding author
- MacQueen, Glenda M.
- Venue
- The International Journal of Neuropsychopharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-12
- Volume
- 6
- Issue
- 4
- Pages
- 391-396
- ISSN
- 1461-1457 (ISSN-L)
- 1469-5111
- OpenAlex
- W2020651237
- Cited by
- 96
- References
- 38
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 8 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 4 · 2012: 5
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The International Journal of Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- maternal separation, early life stress, desipramine, antidepressant treatment, depression, forced swim test, brain-derived neurotrophic factor, hippocampus, dentate gyrus, CA3, neuroplasticity
- MeSH terms
- Animals, Animals, Newborn, Antidepressive Agents, Tricyclic, Depression, Desipramine, Escape Reaction, Female, Hippocampus, Male, Maternal Deprivation, Mice, Inbred C57BL, Motivation, Motor Activity, Pregnancy, Swimming, Dentate Gyrus, Brain-Derived Neurotrophic Factor, Mice
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