The DOI matches its Crossref record; 190 of the 190 references it cites were found in a registry or an index.
Emerging role of the cannabinoid receptor CB 2 in immune regulation: therapeutic prospects for neuroinflammation
Open accessAbstract
There is now a large body of data indicating that the cannabinoid receptor type 2 (CB 2 ) is linked to a variety of immune events. This functional relevance appears to be most salient in the course of inflammation, a process during which there is an increased number of receptors that are available for activation. Studies aimed at elucidating signal transduction events resulting from CB 2 interaction with its native ligands, and of the role of exogenous cannabinoids in modulating this process, are providing novel insights into the role of CB 2 in maintaining a homeostatic immune balance within the host. Furthermore, these studies suggest that the CB 2 may serve as a selective molecular target for therapeutic manipulation of untoward immune responses, including those associated with a variety of neuropathies that exhibit a hyperinflammatory component.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Endocannabinoids mediate inflammation by regulating cytokines at different steps throughout the inflammatory response (Cabral and Griffin-Thomas, 2009).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Cabral and Griffin-Thomas, 2009
In the citing paper
“For example, THC and AEA suppress proinflammatory cytokines and enhance anti-inflammatory cytokines in both innate and adaptive immune responses (Cabral and Griffin-Thomas, 2009).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Cabral and Griffin-Thomas, 2009
In the citing paper
“Cannabinoids also inhibit the cell-specific proliferation of B and T cells (Cabral and Griffin-Thomas, 2009;Klein and Cabral, 2006).”
From The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain (2018) · cites this paper as Cabral and Griffin-Thomas, 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. J. (1997) · Nature · doi:10.1038/39807 · Cited by 9,265
Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633
Molecular characterization of a peripheral receptor for cannabinoids
Munro, S., Thomas, K. L., & Abu-Shaar, M. (1993) · Nature · doi:10.1038/365061a0 · Cited by 5,092
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011
Microglia: a sensor for pathological events in the CNS
Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396
Cell Migration: A Physically Integrated Molecular Process
Lauffenburger, D. A., & Horwitz, A. F. (1996) · Cell · doi:10.1016/s0092-8674(00)81280-5 · Cited by 3,915
Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., et al. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00109-d · Cited by 2,913
The many roles of chemokines and chemokine receptors in inflammation
Charo, I. F., & Ransohoff, R. M. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052723 · Cited by 2,523
Cannabinoid receptor localization in brain.
Herkenham, M., Lynn, A. B., Little, M. D., Johnson, M. R., Melvin, L. S., de Costa, B. R., & Rice, K. C. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.1932 · Cited by 2,321
Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines.
Baggiolini, M., Dewald, B., & Moser, B. (1994) · PubMed · Cited by 2,232
Research works printed but not linked: 4
- http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=105400 (amyotrophic lateral sclerosis)
- http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=114610 (CB1)
- http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=605051 (CB2) The National Institute of Drug Abuse website includes listings of clinical trials:
- http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=126200 (multiple sclerosis)
Cited by
Sorted by citations
Items 401–418 of 418
Love, C. R. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27156626
Inoshita, T., & Kawaguchi, S.-Y. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1842304
Arain, U., Dedman, K., Cooper, M., Ashfaq, O., Ait‐Aissa, K., Munkhsaikhan, U., Apu, E. H., Sahyoun, A. M., Dabbous, M. K., Kassan, M., et al. (2026) · Pharmaceuticals · doi:10.3390/ph19091406
Stone, A. M., Veltre, V. L., Camp, O. G., Biernat, M. M., & Abu‐Soud, H. M. (2026) · Reproductive Sciences · doi:10.1007/s43032-026-02201-9
Involvement of CB1 and CB2 receptors in neuroprotective effects of cannabinoids
de Lago, E., Ruiz, J. F., & Rodríguez‐Cueto, C. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-34176-2.00011-0
Graziano, G., Mastropasqua, F., Fanizzi, A., Papadopoulos, M., Laghezza, A., Mammone, M., Musillo, G. R., Mangiatordi, G. F., Brea, J. M., Loza, M. I., et al. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6c02401
Bietar, B., Tanner, S., Abdolmohammadi, P., Kasheke, G. D. S., Zhou, J., & Lehmann, C. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.117539
Rigillo, G., Benatti, C., Rivi, V., Ciani, M., Martusciello, I., Imbeni, F., Blom, J. M. C., Pani, L., Alboni, S., & Tascedda, F. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.179441
Maternal Cannabis Use and Secretory IgA and IgM Concentrations in Breast Milk
Moshtagh, C. R., Galan, L. H., Mbuagbaw, L., Raha, S., Ratcliffe, E. M., & Shea, A. K. (2026) · Breastfeeding Medicine · doi:10.1177/15568253261499031
BindingDB (2021) · UC San Diego · doi:10.7270/q2222z25
BindingDB (2012) · UC San Diego · doi:10.7270/q26m376d
BindingDB Entry 50013009: Amide Bond Bioisosteres: Strategies, Synthesis, and Successes.
BindingDB (2022) · UC San Diego · doi:10.7270/q2w95dw9
BindingDB Entry 50002913: Bioactive products from singlet oxygen photooxygenation of cannabinoids.
BindingDB (2020) · UC San Diego · doi:10.7270/q2d50qn8
Endocannabinoid regulation of microglia–astrocyte crosstalk in Alzheimer’s disease
Rao, J. S., Tangarife, M. A., Rodríguez‐Soacha, D. A., & Mukunda, R. (2026) · Academia Drug Development and Pharmacotherapy · doi:10.20935/acaddrug8564
Metadata
- Authors
- Cabral, G. A., & Griffin-Thomas, L.
- Affiliations
- Virginia Commonwealth University (US)
- Corresponding author
- Cabral, Guy A.
- Venue
- Expert Reviews in Molecular Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2009-01
- Volume
- 11
- Pages
- e3-e3
- ISSN
- 1462-3994 (ISSN-L)
- PMC
- PMC2768535
- OpenAlex
- W2023366312
- Cited by
- 408
- References
- 190
- Citations by year
- 2026: 25 · 2025: 37 · 2024: 22 · 2023: 24 · 2022: 23 · 2021: 29 · 2020: 34 · 2019: 24 · 2018: 28 · 2017: 37 · 2016: 13 · 2015: 15 · 2014: 22 · 2013: 22 · 2012: 17
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Expert Reviews in Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Cambridge
- National Institutes of Health
- National Institute on Drug Abuse (DA005832, R01DA005832, R01DA029532)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Keywords
- CB2 receptor, immune regulation, neuroinflammation, signal transduction, exogenous cannabinoids, immune homeostasis, neuropathy, hyperinflammation, therapeutic target
- MeSH terms
- Amino Acid Sequence, Animals, Humans, Inflammation, Molecular Sequence Data, Nervous System, Research, Neuroimmunomodulation, Receptor, Cannabinoid, CB2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
