Insight, positive and negative symptoms, hope, depression and self-stigma: a comprehensive model of mutual influences in schizophrenia spectrum disorders
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Aims.: Insight, positive and negative symptoms, hope, depression and self-stigma are relevant variables in schizophrenia spectrum disorders. So far, research on their mutual influences has been patchy. This study simultaneously tests the associations between these variables. Methods.: A total of 284 people with schizophrenia spectrum disorders were assessed using the Schedule for the Assessment of Insight, Positive and Negative Syndrome Scale, Integrative Hope Scale, Centre for Epidemiological Studies Depression Scale and Internalized Stigma of Mental Illness scale. Path analysis was applied to test the hypothesized relationships between the variables. Results.: Model support was excellent. Strong and mutual causal influences were confirmed between hope, depression and self-stigma. The model supported the assumption that insight diminishes hope and increases depression and self-stigma. While negative symptoms directly affected these three variables, reducing hope and increasing depression and self-stigma, positive symptoms did not. However, positive symptoms diminished self-stigma on a pathway via insight. Conclusions.: This study provides a comprehensive synopsis of the relationships between six variables relevant for schizophrenia spectrum disorders. Research implications include the need to investigate determinants of consequences of insight, and the sequence of influences exerted by positive and negative symptoms. Clinical implications include the importance of interventions against self-stigma and of taking a contextualized approach to insight.
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Individuals with psychosis may consider a meaningful life no longer viable.
“As reviewed above, stigma may result in insight leading to despair, and individuals may consider a meaningful life no longer a viable possibility 39,81 .”
From Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments (2018) · cites this paper as [81]
Stigma may cause insight to lead to despair.
“As reviewed above, stigma may result in insight leading to despair, and individuals may consider a meaningful life no longer a viable possibility 39,81 .”
From Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments (2018) · cites this paper as [81]
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- Authors
- Schrank, B., Amering, M., Hay, A. G., Weber, M., & Sibitz, I.
- Affiliations
- King's College London (GB)
- Medical University of Vienna (AT)
- Corresponding author
- Schrank, B.
- ORCID
- Venue
- Epidemiology and Psychiatric Sciences
- Publisher
- Cambridge University Press (CUP)
- Published
- 2013-07-24
- Volume
- 23
- Issue
- 3
- Pages
- 271-279
- ISSN
- 2045-7960 (ISSN-L)
- 2045-7979
- PMC
- PMC6998353
- OpenAlex
- W2096684528
- Cited by
- 97
- References
- 46
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 5 · 2021: 7 · 2020: 10 · 2019: 11 · 2018: 10 · 2017: 15 · 2016: 15 · 2015: 4 · 2014: 1 · 2013: 1
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Epidemiology and Psychiatric Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Social Sciences › Psychology › Applied Psychology › Optimism, Hope, and Well-being
- Keywords
- schizophrenia spectrum disorders, insight, positive symptoms, negative symptoms, hope, depression, self-stigma, reciprocal effects, causal pathways
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