The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Continuous-Flow Chemical Processing on a Microchip by Combining Microunit Operations and a Multiphase Flow Network
Abstract
A new design and construction methodology for integration of complicated chemical processing on a microchip was proposed. This methodology, continuous-flow chemical processing (CFCP), is based on a combination of microunit operations (MUOs) and a multiphase flow network. Chemical operations in microchannels, such as mixing, reaction, and extraction, were classified into several MUOs. The complete procedure for Co(II) wet analysis, including a chelating reaction, solvent extraction, and purification was decomposed into MUOs and reconstructed as CFCP on a microchip. Chemical reaction and molecular transport were realized in and between continuous liquid flows in a multiphase flow network, such as aqueous/aqueous, aqueous/organic, and aqueous/organic/aqueous flows. When the determination of Co(II) in an admixture of Cu(II) was carried out using this methodology, the determination limit (2sigma) was obtained as 18 nM, and the absolute amount of Co chelates detected was 0.13 zmol, that is, 78 chelates. The sample analysis time was faster than that of a conventional processing system. Moreover, troublesome operations such as phase separation and acid and alkali washing, all necessary for the conventional system, were simplified. The CFCP methodology proposed here can be applied to various on-chip applications.
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Citations
Cites
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Self-citationSorouraddin, H. M., Hibara, A., Proskurnin, М. А., & Kitamori, T. (2000) · Analytical Sciences · doi:10.2116/analsci.16.1033 · Cited by 60
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Cited by
Solvent Compatibility of Poly(dimethylsiloxane)-Based Microfluidic Devices
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Microchemical systems for continuous-flow synthesis
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Metadata
- Authors
- Tokeshi, M., Minagawa, T., Uchiyama, K., Hibara, A., Sato, K., Hisamoto, H., & Kitamori, T.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2002-02-21
- Volume
- 74
- Issue
- 7
- Pages
- 1565-1571
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W1980781913
- Cited by
- 342
- References
- 12
- FWCI
- 20.41
- Type
- journal article
- Language
- en
- Open access
- closed
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