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Direct Molecular Analysis of Whole-Body Animal Tissue Sections by Imaging MALDI Mass Spectrometry
Abstract
Imaging mass spectrometry (IMS) that utilizes matrix-assisted laser desorption/ionization (MALDI) technology can provide a molecular ex vivo view of resected organs or whole-body sections from an animal, making possible the label-free tracking of both endogenous and exogenous compounds with spatial resolution and molecular specificity. Drug distribution and, for the first time, individual metabolite distributions within whole-body tissue sections can be detected simultaneously at various time points following drug administration. IMS analysis of tissues from 8 mg/kg olanzapine dosed rats revealed temporal distribution of the drug and metabolites that correlate to previous quantitative whole-body autoradiography studies. Whole-body MALDI IMS is further extended to detecting proteins from organs present in a whole-body sagittal tissue section. This technology will significantly help advance the analysis of novel therapeutics and may provide deeper insight into therapeutic and toxicological processes, revealing at the molecular level the cause of efficacy or side effects often associated with drug administration.
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Citations
Cites
Molecular Imaging of Biological Samples: Localization of Peptides and Proteins Using MALDI-TOF MS
Caprioli, R. M., Farmer, T. B., & Gile, J. (1997) · Analytical Chemistry · doi:10.1021/ac970888i · Cited by 2,234
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Cited by
McDonnell, L. A., & Heeren, R. M. A. (2007) · Mass Spectrometry Reviews · doi:10.1002/mas.20124 · Cited by 1,082
Tissue Penetration of Antifungal Agents
Felton, T., Troke, P. F., & Hope, W. W. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00046-13 · Cited by 426
Stoeckli, M., Staab, D., & Schweitzer, A. (2007) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2006.10.007 · Cited by 295
Mass spectrometry imaging for drug distribution studies
Prideaux, B., & Stoeckli, M. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.07.028 · Cited by 279
MALDI imaging mass spectrometry of human tissue: method challenges and clinical perspectives
Seeley, E. H., & Caprioli, R. M. (2011) · Trends in Biotechnology · doi:10.1016/j.tibtech.2010.12.002 · Cited by 197
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Metadata
- Authors
- Khatib-Shahidi, S., Andersson, M., Herman, J. L., Gillespie, T. A., & Caprioli, R. M.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-08-03
- Volume
- 78
- Issue
- 18
- Pages
- 6448-6456
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- OpenAlex
- W2019571295
- Cited by
- 505
- References
- 1
- FWCI
- 14.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Khatib-Shahidi, S., Andersson, M., Herman, J. L., Gillespie, T. A., & Caprioli, R. M. (2006). Direct Molecular Analysis of Whole-Body Animal Tissue Sections by Imaging MALDI Mass Spectrometry. Analytical Chemistry. https://doi.org/10.1021/ac060788p
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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