Cited by 1,813Photodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsPorphyrin and Phthalocyanine Chemistry

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Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Pham, Thanh Chung, Nguyen, Van-Nghia, Choi, Yeonghwan, Lee, Songyi, Yoon, Juyoung·2021·Chemical Reviews

DOI 10.1021/acs.chemrev.1c00381

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Abstract

This review presents a robust strategy to design photosensitizers (PSs) for various species. Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the use of light combined with a light-activated chemical, referred to as a PS. Attractively, PDT is one of the alternatives to conventional cancer treatment due to its noninvasive nature, high cure rates, and low side effects. PSs play an important factor in photoinduced reactive oxygen species (ROS) generation. Although the concept of photosensitizer-based photodynamic therapy has been widely adopted for clinical trials and bioimaging, until now, to our surprise, there has been no relevant review article on rational designs of organic PSs for PDT. Furthermore, most of published review articles in PDT focused on nanomaterials and nanotechnology based on traditional PSs. Therefore, this review aimed at reporting recent strategies to develop innovative organic photosensitizers for enhanced photodynamic therapy, with each example described in detail instead of providing only a general overview, as is typically done in previous reviews of PDT, to provide intuitive, vivid, and specific insights to the readers.

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Authors: Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J.
Affiliations: Pukyong National University (KR)
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea
Ewha Womans University (KR)
Corresponding author: Lee, Songyi
Yoon, Juyoung
ORCID: Pham, Thanh Chung
Nguyen, Van-Nghia
Lee, Songyi
Yoon, Juyoung
Venue: Chemical Reviews
Publisher: American Chemical Society (ACS)
Published: 2021-09-28
Volume: 121
Issue: 21
Pages: 13454-13619
ISSN: 0009-2665 (ISSN-L)
1520-6890
DOI: 10.1021/acs.chemrev.1c00381
OpenAlex: W3204360553
Cited by: 1,813
References: 1,199
Citations by year: 2026: 308 · 2025: 457 · 2024: 466 · 2023: 338 · 2022: 240 · 2021: 4
FWCI: 42.14
Type: journal article
Language: en
Open access: closed
Licence: doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-045 (stm-asf)
Locations: Chemical Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Research Foundation of Korea (2012R1A3A2048814, 2017R1A6A3A04004954, 2021R1A6A1A10039823)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Physical Sciences › Materials Science › Materials Chemistry › Porphyrin and Phthalocyanine Chemistry
Keywords: photosensitizers, photodynamic therapy, organic photosensitizers, reactive oxygen species, cancer therapy, rational design
MeSH terms: Humans, Neoplasms, Photochemotherapy, Photosensitizing Agents, Reactive Oxygen Species, Nanotechnology

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Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

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