Cited by 1,813Photodynamic Therapy Research StudiesNanoplatforms for cancer theranosticsPorphyrin and Phthalocyanine Chemistry

The DOI matches its Crossref record; 1,197 of the 1,199 references it cites were found in a registry or an index.

Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Pham, Thanh Chung, Nguyen, Van-Nghia, Choi, Yeonghwan, Lee, Songyi, Yoon, Juyoung·2021·Chemical Reviews

Abstract

This review presents a robust strategy to design photosensitizers (PSs) for various species. Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the use of light combined with a light-activated chemical, referred to as a PS. Attractively, PDT is one of the alternatives to conventional cancer treatment due to its noninvasive nature, high cure rates, and low side effects. PSs play an important factor in photoinduced reactive oxygen species (ROS) generation. Although the concept of photosensitizer-based photodynamic therapy has been widely adopted for clinical trials and bioimaging, until now, to our surprise, there has been no relevant review article on rational designs of organic PSs for PDT. Furthermore, most of published review articles in PDT focused on nanomaterials and nanotechnology based on traditional PSs. Therefore, this review aimed at reporting recent strategies to develop innovative organic photosensitizers for enhanced photodynamic therapy, with each example described in detail instead of providing only a general overview, as is typically done in previous reviews of PDT, to provide intuitive, vivid, and specific insights to the readers.

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Crossref · 10.1021/acs.chemrev.1c00381

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Research works printed but not linked: 20

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Metadata

Authors
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J.
Affiliations
  • Pukyong National University (KR)
  • Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea
  • Ewha Womans University (KR)
Corresponding author
  • Lee, Songyi
  • Yoon, Juyoung
Venue
Chemical Reviews
Published
2021-09-28
Volume
121
Issue
21
Pages
13454-13619
ISSN
  • 0009-2665 (ISSN-L)
  • 1520-6890
OpenAlex
W3204360553
Cited by
1,813
References
1,199
Citations by year
2026: 308 · 2025: 457 · 2024: 466 · 2023: 338 · 2022: 240 · 2021: 4
FWCI
42.14
Type
journal article
Language
en
Open access
closed
Locations
  • Chemical Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Research Foundation of Korea (2012R1A3A2048814, 2017R1A6A3A04004954, 2021R1A6A1A10039823)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Materials Chemistry › Porphyrin and Phthalocyanine Chemistry
Keywords
photosensitizers, photodynamic therapy, organic photosensitizers, reactive oxygen species, cancer therapy, rational design
MeSH terms
Humans, Neoplasms, Photochemotherapy, Photosensitizing Agents, Reactive Oxygen Species, Nanotechnology

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