The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Fundamentals and Applications of Photo-Cross-Linking in Bioprinting
Abstract
This review provides a detailed overview of the rapidly advancing field of biofabrication, particularly with regards to the use of photo-cross-linking (i.e., light-based) techniques. The major emphasis of this review is on the fundamentals of photo-cross-linking and key criteria identified for the successful design and implementation of photo-cross-linked bioinks and bioresins in extrusion-based and lithography-based bioprinting. The general mechanisms associated with photo-cross-linking (e.g., free-radical chain polymerization, thiol–ene, photomediated redox) of natural and synthetic materials are described to inform bioink and bioresin design, which includes the selection of polymers, functional group modifications, photoinitiators, and light sources that enable facile and cytocompatible photo-cross-linking. Depending on material selection and the bioprinting technique of interest, we describe the specific bioink or bioresin properties and criteria that must be achieved to ensure optimal printability and utility. Finally, examples of current state-of-the-art applications of light-based bioprinting for in vitro tissue models, tissue engineering, and regenerative medicine are provided to further motivate future opportunities within the bioprinting landscape that are facilitated with light.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015
Roth, G. A., Johnson, C., Abajobir, A., Abd-Allah, F., Abera, S. F., Abyu, G., Ahmed, M., Aksut, B., Alam, T., Alam, K., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.04.052 · Cited by 3,791
Oxidative DNA damage: mechanisms, mutation, and disease
Cooke, M. S., Evans, M. D., Dizdaroglu, M., & Lunec, J. (2003) · The FASEB Journal · doi:10.1096/fj.02-0752rev · Cited by 3,245
Three-dimensional microfabrication with two-photon-absorbed photopolymerization
Maruo, S., Nakamura, O., & Kawata, S. (1997) · Optics Letters · doi:10.1364/ol.22.000132 · Cited by 1,952
25th Anniversary Article: Engineering Hydrogels for Biofabrication
Malda, J., Visser, J., Melchels, F. P., Jüngst, T., Hennink, W. E., Dhert, W. J. A., Groll, J., & Hutmacher, D. W. (2013) · Advanced Materials · doi:10.1002/adma.201302042 · Cited by 1,901
3D bioprinting of collagen to rebuild components of the human heart
Lee, A., Hudson, A. R., Shiwarski, D. J., Tashman, J. W., Hinton, T. J., Yerneni, S., Bliley, J. M., Campbell, P. G., & Feinberg, A. W. (2019) · Science · doi:10.1126/science.aav9051 · Cited by 1,782
Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties
Kloxin, A. M., Kasko, A. M., Salinas, C. N., & Anseth, K. S. (2009) · Science · doi:10.1126/science.1169494 · Cited by 1,748
Thiol-ene “click” reactions and recent applications in polymer and materials synthesis
Lowe, A. B. (2010) · Polym. Chem. · doi:10.1039/b9py00216b · Cited by 1,563
Markstedt, K., Mantas, A., Tournier, I., Martínez Ávila, H., Hägg, D., & Gatenholm, P. (2015) · Biomacromolecules · doi:10.1021/acs.biomac.5b00188 · Cited by 1,528
Billiet, T., Gevaert, E., De Schryver, T., Cornelissen, M., & Dubruel, P. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.09.078 · Cited by 1,015
Controlled Degradation and Mechanical Behavior of Photopolymerized Hyaluronic Acid Networks
Burdick, J. A., Chung, C., Jia, X., Randolph, M. A., & Langer, R. (2005) · Biomacromolecules · doi:10.1021/bm049508a · Cited by 777
Self-citation
Cited by
Printability and shape fidelity of bioinks in 3D bioprinting
Schwab, A., Levato, R., D’Este, M., Piluso, S., Eglin, D., & Malda, J. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00084 · Cited by 1,359
3D printing of functional microrobots
Li, J., & Pumera, M. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01062f · Cited by 303
Digital Light Processing Based Bioprinting with Composable Gradients
Wang, M., Li, W., Mille, L. S., Ching, T., Luo, Z., Tang, G., Garciamendez, C. E., Lesha, A., Hashimoto, M., & Zhang, Y. S. (2022) · Advanced Materials · doi:10.1002/adma.202107038 · Cited by 206
Kurhade, R. R., Shaikh, M. S., Nagulwar, V., & Kale, M. A. (2025) · International Journal of Polymeric Materials and Polymeric Biomaterials · doi:10.1080/00914037.2024.2391973 · Cited by 55
Sensors-integrated organ-on-a-chip for biomedical applications
Chen, H., Luo, Z., Lin, X., Zhu, Y., & Zhao, Y. (2023) · Nano Research · doi:10.1007/s12274-023-5651-9 · Cited by 47
Metadata
- Authors
- Lim, K. S., Galarraga, J. H., Cui, X., Lindberg, G. C. J., Burdick, J. A., & Woodfield, T. B. F.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-04-17
- Volume
- 120
- Issue
- 19
- Pages
- 10662-10694
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W3017274890
- Cited by
- 416
- References
- 18
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Fundamentals and Applications of Photo-Cross-Linking in Bioprinting. https://app.cochat.ai/papers/10.1021/acs.chemrev.9b00812
- The paper
- Lim, K. S., Galarraga, J. H., Cui, X., Lindberg, G. C. J., Burdick, J. A., & Woodfield, T. B. F. (2020). Fundamentals and Applications of Photo-Cross-Linking in Bioprinting. Chemical Reviews. https://doi.org/10.1021/acs.chemrev.9b00812
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
