Butyrylcholinesterase and the cholinergic system

A new and rapid colorimetric determination of acetylcholinesterase activity

Ellman, G. L., Courtney, K. D., Andres, V., & Featherstone, R. M. (1961) · Biochemical Pharmacology · doi:10.1016/0006-2952(61)90145-9 · Cited by 27,221 · see citing works

The Mouse Brain in Stereotaxic Coordinates

Paxinos, G. (2001) · Cited by 12,859 · see citing works

A "DIRECT-COLORING" THIOCHOLINE METHOD FOR CHOLINESTERASES

Karnovsky, M. J., & ROOTS, L. (1964) · Journal of Histochemistry & Cytochemistry · doi:10.1177/12.3.219 · Cited by 3,389 · see citing works

Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1–Ch6)

Mesulam, M. M., Mufson, E. J., Wainer, B. H., & Levey, A. I. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90108-2 · Cited by 2,329 · see citing works

A Histochemical Method for Localizing Cholinesterase Activity.

Koelle, G. B., & Friedenwald, J. S. (1949) · Experimental Biology and Medicine · doi:10.3181/00379727-70-17013 · Cited by 1,192 · see citing works

Distribution of cholinergic neurons in rat brain: Demonstrated by the immunocytochemical localization of choline acetyltransferase

Armstrong, D. M., Saper, C. B., Levey, A. I., Wainer, B. H., & Terry, R. D. (1983) · The Journal of Comparative Neurology · doi:10.1002/cne.902160106 · Cited by 970 · see citing works

Neurobiology of butyrylcholinesterase

Darvesh, S., Hopkins, D. A., & Geula, C. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1035 · Cited by 896 · see citing works

The biology of cholinesterases

Silver, A. (1974) · Medical Entomology and Zoology · Cited by 890 · see citing works

Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β-amyloid peptide in rodent

Greig, N. H., Utsuki, T., Ingram, D. K., Wang, Y., Pepeu, G., Scali, C., Yu, Q.-S., Mamczarz, J., Holloway, H. W., Giordano, T., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508575102 · Cited by 745 · see citing works

Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine

Mesulam, M. M., Guillozet-Bongaarts, A. L., Shaw, P. L., Levey, A. I., Duysen, E. G., & Lockridge, O. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00613-3 · Cited by 654 · see citing works

Functional neuroanatomy of the parahippocampal region: The lateral and medial entorhinal areas

Kerr, K. M., Agster, K. L., Furtak, S. C., & Burwell, R. D. (2007) · Hippocampus · doi:10.1002/hipo.20315 · Cited by 433 · see citing works

Diffuse transmission by acetylcholine in the CNS

Descarries, L., Gisiger, V., & Steriade, M. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00050-6 · Cited by 406 · see citing works

Cholinesterase-Containing Systems of the Brain of the Rat

Shute, C. C. D., & Lewis, P. R. (1963) · Nature · doi:10.1038/1991160a0 · Cited by 359 · see citing works

Co-localization of acetylcholinesterase and choline acetyltransferase in the rat cerebrum

Levey, A. I., Wainer, B. H., Mufson, E. J., & Mesulam, M. M. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90042-8 · Cited by 359 · see citing works

Abundant Tissue Butyrylcholinesterase and Its Possible Function in the Acetylcholinesterase Knockout Mouse

Li, B., Stribley, J. A., Ticu, A., Xie, W., Schopfer, L. M., HAMMOND, P. I., Brimijoin, S., Hinrichs, S. H., & Lockridge, O. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.751320.x · Cited by 354 · see citing works

Phasic acetylcholine release and the volume transmission hypothesis: time to move on

Sarter, M. F., Parikh, V., & Howe, W. M. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2635 · Cited by 340 · see citing works

Choline Acetyltransferase-Containing Neurons in Rodent Brain Demonstrated by Immunohistochemistry

Kimura, H., McGeer, P. L., Peng, F., & McGeer, E. G. (1980) · Science · doi:10.1126/science.6990490 · Cited by 333 · see citing works

Identification of central cholinergic neurons containing both choline acetyltransferase and acetylcholinesterase and of central neurons containing only acetylcholinesterase

Eckenstein, F. P., & Sofroniew, M. V. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-11-02286.1983 · Cited by 331 · see citing works

Habenula “Cholinergic” Neurons Corelease Glutamate and Acetylcholine and Activate Postsynaptic Neurons via Distinct Transmission Modes

Ren, J., Qin, C., Hu, F., Tan, J., Qiu, L., Zhao, S., Feng, G., & Luo, M. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.038 · Cited by 315 · see citing works

Widely spread butyrylcholinesterase can hydrolyze acetylcholine in the normal and Alzheimer brain

Mesulam, M., Guillozet, A., Shaw, P., & Quinn, B. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0462 · Cited by 314 · see citing works

Choline acetyltransferase-immunoreactive neurons intrinsic to rodent cortex and distinction from acetylcholinesterase-positive neurons

Levey, A. I., Wainer, B. H., Rye, D. B., Mufson, E. J., & Mesulam, M. M. (1984) · Neuroscience · doi:10.1016/0306-4522(84)90234-3 · Cited by 276 · see citing works

Postnatal Developmental Delay and Supersensitivity to Organophosphate in Gene-Targeted Mice Lacking Acetylcholinesterase

Xie, W., Stribley, J. A., Chatonnet, A., Wilder, P. J., Rizzino, A., McComb, R. D., Taylor, P., Hinrichs, S. H., & Lockridge, O. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39312-7 · Cited by 255 · see citing works

Subicular efferents are organized mostly as parallel projections: A double-labeling, retrograde-tracing study in the rat

Naber, P. A., & Witter, M. P. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980413)393:3 · Cited by 219 · see citing works

Distinct roles of medial and lateral entorhinal cortex in spatial cognition

Van Cauter, T., Camon, J., Alvernhe, A., Elduayen, C., Sargolini, F., & Save, E. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs033 · Cited by 196 · see citing works

The immunohistochemical localization of choline acetyltransferase in the cat brain

Vincent, S. R., & Reiner, P. B. (1987) · Brain Research Bulletin · doi:10.1016/0361-9230(87)90015-3 · Cited by 187 · see citing works

Excessive hippocampal acetylcholine levels in acetylcholinesterase‐deficient mice are moderated by butyrylcholinesterase activity

Hartmann, J., Kiewert, C., Duysen, E. G., Lockridge, O., Greig, N. H., & Klein, J. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04347.x · Cited by 158 · see citing works

Butyrylcholinesterase Is Associated With β-Amyloid Plaques in the Transgenic APP SWE /PSEN1dE9 Mouse Model of Alzheimer Disease

Darvesh, S., Cash, M. K., Reid, G. A., Martin, E. V., Mitnitski, A., & Geula, C. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31823cc7a6 · Cited by 151 · see citing works

Cholinergic innervation of the human thalamus: Dual origin and differential nuclear distribution

Heckers, S., Geula, C., & Mesulam, M. M. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903250107 · Cited by 132 · see citing works

Differential distribution of butyrylcholinesterase and acetylcholinesterase in the human thalamus

Darvesh, S., & Hopkins, D. A. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10751 · Cited by 128 · see citing works

The organization of the brainstem and spinal cord of the mouse: Relationships between monoaminergic, cholinergic, and spinal projection systems

VanderHorst, V., & Ulfhake, B. (2005) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2005.08.003 · Cited by 123 · see citing works

Cholinergic innervation of mouse forebrain structures

Kitt, C. A., Höhmann, C. F., COYLE, J. T., & Price, D. L. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903410110 · Cited by 104 · see citing works

Sensitivity of butyrylcholinesterase knockout mice to (−)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission

Duysen, E. G., Li, B., Darvesh, S., & Lockridge, O. (2006) · Toxicology · doi:10.1016/j.tox.2006.11.069 · Cited by 102 · see citing works

Antibody to bovine choline acetyltransferase and immunofluorescent localisation of the enzyme in neurones

Eng, L. F., Uyeda, C. T., CHAO, L. P., et al. (1974) · Nature · doi:10.1038/250243a0 · Cited by 91 · see citing works

Morphological and functional characterization of cholinergic interneurons in the dorsal horn of the mouse spinal cord

Mesnage, B., Gaillard, S., Godin, A. G., Rodeau, J., Hammer, M., Von Engelhardt, J., Wiseman, P. W., De Koninck, Y., Schlichter, R., & Cordero‐Erausquin, M. (2011) · Journal of Comparative Neurology · doi:10.1002/cne.22668 · Cited by 71 · see citing works

N1phenethyl-norcymserine, a selective butyrylcholinesterase inhibitor, increases acetylcholine release in rat cerebral cortex: A comparison with donepezil and rivastigmine

Cerbai, F., Giovannini, M. G., Melani, C., Enz, A., & Pepeu, G. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.06.053 · Cited by 59 · see citing works

Effects of acetylcholine on neuronal properties in entorhinal cortex

Heys, J. G., Schultheiss, N. W., Shay, C. F., Tsuno, Y., & Hasselmo, M. E. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00032 · Cited by 56 · see citing works

A comparative histochemical mapping of the distribution of butyryl cholinesterase in the brains of four species of mammals, including man

Friede, R. L. (2008) · Acta Anatomica · doi:10.1159/000142920 · Cited by 52 · see citing works

Butyrylcholinesterase‐rich neurons in rat brain demonstrated by a sensitive histochemical method

Tago, H., Maeda, T., McGeer, P. L., & Kimura, H. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903250212 · Cited by 52 · see citing works

The Brain Cholinergic System In Health And Disease

Giacobini, E., & Pepeu, G. (2006) · Medical Entomology and Zoology · Cited by 47 · see citing works

Gene-Delivered Butyrylcholinesterase Is Prophylactic against the Toxicity of Chemical Warfare Nerve Agents and Organophosphorus Compounds

Parikh, K., Duysen, E. G., Snow, B., Jensen, N. S., Manne, V., Lockridge, O., & Chilukuri, N. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.175646 · Cited by 44 · see citing works

The State of Cholinergic Structures in Forebrain of Bulbectomized Mice

Bobkova, N. V., Nesterova, I. V., & Нестеров, В. В. (2001) · Bulletin of Experimental Biology and Medicine · doi:10.1023/a:1017907511482 · Cited by 36 · see citing works

The Characteristics of Supramammillary Cells Projecting to the Hippocampus in Stress Response in the Rat

Choi, W. K., Wirtshafter, D., Park, H.-J., Lee, M., Her, S., & Shim, I. (2012) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2012.16.1.17 · Cited by 23 · see citing works

Butyrylcholinesterase activity in the rat forebrain and upper brainstem: Postnatal development and adult distribution

Geula, C., & Nagykery, N. G. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.12.015 · Cited by 23 · see citing works

Colocalization of acetylcholinesterase, butyrylcholinesterase and choline acetyltransferase in rat spinal cord

Miš, K. (2005) · Human & Experimental Toxicology · doi:10.1191/0960327105ht560oa · Cited by 2 · see citing works

Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer’s disease

Guzior, N., Wi.eckowska, A., Panek, D., & Malawska, B. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666141106122628 · Cited by 323 · see citing works

Multitarget Therapeutic Strategies for Alzheimer’s Disease: Review on Emerging Target Combinations

Maramai, S., Benchekroun, M., Gabr, M. T., & Yahiaoui, S. (2020) · BioMed Research International · doi:10.1155/2020/5120230 · Cited by 121 · see citing works

Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy

Arya, A., Chahal, R., Rao, R., Rahman, M. H., Kaushik, D., Akhtar, M. F., Saleem, A., Khalifa, S. M. A., El-Seedi, H. R., Kamel, M., et al. (2021) · Biomolecules · doi:10.3390/biom11030350 · Cited by 111 · see citing works

New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer’s Disease Treatment

Makhaeva, G. F., Kovaleva, N. V., Boltneva, N. P., Lushchekina, S. V., Astakhova, T. Y., Rudakova, E. V., Proshin, A. N., Serkov, I. V., Radchenko, E. V., Palyulin, V. A., et al. (2020) · Molecules · doi:10.3390/molecules25173915 · Cited by 53 · see citing works

New Dual Small Molecules for Alzheimer’s Disease Therapy Combining Histamine H ₃ Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition

Malek, R., Arribas, R. L., Palomino-Antolin, A., Totoson, P., Demougeot, C., Kobrlova, T., Soukup, O., Iriepa, I., Moraleda, I., Diez-Iriepa, D., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00937 · Cited by 45 · see citing works

Nerve growth factor receptor is associated with cholinergic neurons of the basal forebrain but not the pontomesencephalon

Woolf, N. J., Gould, E. A., & Butcher, L. L. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90360-6 · Cited by 212 · see citing works

Fetal rat sympathetic neurons maintained in a serum-free medium retain induced cholinergic characteristics

Higgins, D. M., Iacovitti, L., & Burton, H. (1984) · Developmental Brain Research · doi:10.1016/0165-3806(84)90010-5 · Cited by 7 · see citing works

Experimental immune-mediated damage of septal cholinergic neurons

Kalman, J. L., Engelhardt, J. I., Le, W. D., Xie, W., Kovács, I., Kása, P., & Appel, S. H. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00062-3 · Cited by 20 · see citing works

The effects of nerve growth factor on the development of septal cholinergic neurons in reaggregate cell cultures

Hsiang, J., Heller, A., Hoffmann, P. C., Mobley, W. C., & Wainer, B. H. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90344-8 · Cited by 30 · see citing works

Development of Septal Cholinergic Neurons in Culture: Plating Density and Glial Cells Modulate Effects of NGF on Survival, Fiber Growth, and Expression of Transmitter-Specific Enzymes

Hartikka, J., & Hefti, F. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-08-02967.1988 · Cited by 317 · see citing works