Calcium channelopathies and Alzheimer's disease: Insight into therapeutic success and failures

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works

Alzheimer's Disease: Genes, Proteins, and Therapy

Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063 · see citing works

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

The International Schizophrenia Consortium (2009) · Nature · doi:10.1038/nature08185 · Cited by 4,821 · see citing works

LTP and LTD

Malenka, R. C., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.012 · Cited by 3,968 · see citing works

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., et al. (1999) · Science · doi:10.1126/science.286.5440.735 · Cited by 3,876 · see citing works

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

Kopan, R., & Ilagan, M. X. G. (2009) · Cell · doi:10.1016/j.cell.2009.03.045 · Cited by 3,631 · see citing works

2013 Alzheimer's disease facts and figures

Thies, W. H., & Bleiler, L. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.02.003 · Cited by 3,331 · see citing works

Synaptic Plasticity and Memory: An Evaluation of the Hypothesis

Martin, S. J., Grimwood, P. D., & Morris, R. G. M. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.649 · Cited by 2,794 · see citing works

Long-Term Potentiation--A Decade of Progress?

Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729 · see citing works

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

Tabas, I. A., & Ron, D. (2011) · Nature Cell Biology · doi:10.1038/ncb0311-184 · Cited by 2,603 · see citing works

Amyloid deposition as the central event in the aetiology of Alzheimer’s disease

Hardy, J., & Allsop, D. (1991) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(91)90609-v · Cited by 2,538 · see citing works

Familial Hemiplegic Migraine and Episodic Ataxia Type-2 Are Caused by Mutations in the Ca2+ Channel Gene CACNL1A4

Ophoff, R. A., Terwindt, G. M., Vergouwe, M. N., van Eijk, R., Oefner, P. J., Hoffman, S. M. G., Lamerdin, J. E., Mohrenweiser, H. W., Bulman, D. E., Ferrari, M., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81373-2 · Cited by 2,337 · see citing works

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

Karran, E., Mercken, M., & Strooper, B. D. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3505 · Cited by 2,188 · see citing works

Calcium - a life and death signal

Berridge, M. J., Bootman, M. D., & Lipp, P. (1998) · Nature · doi:10.1038/27094 · Cited by 2,064 · see citing works

Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

Bard, F., Cannon, C., Barbour, R., Burke, R.-L., Games, D., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., et al. (2000) · Nature Medicine · doi:10.1038/78682 · Cited by 2,012 · see citing works

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

Baughman, J. M., Perocchi, F., Girgis, H. S., Plovanich, M. E., Belcher-Timme, C. A., Sancak, Y., Bao, X., Strittmatter, L., Goldberger, O., Bogorad, R., et al. (2011) · Nature · doi:10.1038/nature10234 · Cited by 1,926 · see citing works

Learning induces long-term potentiation in the hippocampus

Whitlock, J. R., Heynen, A. J., Shuler, M. G., & Bear, M. F. (2006) · Science · doi:10.1126/science.1128134 · Cited by 1,913 · see citing works

Cholinesterase inhibitors for Alzheimer's disease

Birks, J. S. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005593 · Cited by 1,906 · see citing works

Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis

Leist, M., Single, B., Castoldi, A. F., Kühnle, S., & Nicotera, P. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.8.1481 · Cited by 1,871 · see citing works

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., & Van Leuven, F. (1998) · Nature · doi:10.1038/34910 · Cited by 1,818 · see citing works

CaV1.2 Calcium Channel Dysfunction Causes a Multisystem Disorder Including Arrhythmia and Autism

Splawski, I., Timothy, K. W., Sharpe, L. M., Decher, N., Kumar, P., Bloise, R., Napolitano, C., Schwartz, P. J., Joseph, R. M., Condouris, K., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.011 · Cited by 1,586 · cited 1× · see citing works

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

Stefani, D. D., Raffaello, A., Teardo, E., Szabò, I., & Rizzuto, R. (2011) · Nature · doi:10.1038/nature10230 · Cited by 1,431 · see citing works

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

Holmes, C., Boche, D., Wilkinson, D., Yadegarfar, G., Hopkins, V., Bayer, A., Jones, R. W., Bullock, R., Love, S., Neal, J. W., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61075-2 · Cited by 1,416 · cited 1× · see citing works

Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report

Nicoll, J. A. R., Wilkinson, D., Holmes, C., Steart, P., Markham, H., & Weller, R. O. (2003) · Nature Medicine · doi:10.1038/nm840 · Cited by 1,397 · see citing works

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

Lewis, J., McGowan, E., Rockwood, J., Melrose, H., Nacharaju, P., Van Slegtenhorst, M., Gwinn-Hardy, K., Murphy, M. P., Baker, M., Yu, X., et al. (2000) · Nature Genetics · doi:10.1038/78078 · Cited by 1,371 · see citing works

Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization

Orgogozo, J.-M., Gilman, S., Dartigues, J.-F., Laurent, B., Puel, M., Kirby, L. C., Jouanny, P., Dubois, B., Eisner, L., Flitman, S., et al. (2003) · Neurology · doi:10.1212/01.wnl.0000073623.84147.a8 · Cited by 1,356 · see citing works

Clinical effects of Aβ immunization (AN1792) in patients with AD in an interrupted trial

Gilman, S., Koller, M., Black, R. S., Jenkins, L., Griffith, S. G., Fox, N. C., Eisner, L., Kirby, L., Rovira, M. B., Forette, F., et al. (2005) · Neurology · doi:10.1212/01.wnl.0000159740.16984.3c · Cited by 1,329 · see citing works

Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease

DeMattos, R. B., Bales, K. R., Cummins, D. J., Dodart, J.-C., Paul, S. M., & Holtzman, D. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151261398 · Cited by 1,298 · see citing works

Alzheimer’s disease: Clinical trials and drug development

Mangialasche, F., Solomon, A., Winblad, B., Mecocci, P., & Kivipelto, M. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70119-8 · Cited by 1,217 · see citing works

The worldwide economic impact of dementia 2010

Wimo, A. B., Jönsson, L., Bond, J., Prince, M. J., Winblad, B. G., & International, A. D. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.11.006 · Cited by 1,142 · see citing works

Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus

Mulkey, R. M., & Malenka, R. C. (1992) · Neuron · doi:10.1016/0896-6273(92)90248-c · Cited by 1,113 · see citing works

Tau pathology in Alzheimer disease and other tauopathies

Iqbal, K., del C. Alonso, A., Chen, S., Chohan, M. O., El-Akkad, E., Gong, C.-X., Khatoon, S., Li, B., Liu, F., Rahman, A., et al. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.09.008 · Cited by 1,037 · see citing works

Neuregulin 1 in neural development, synaptic plasticity and schizophrenia

Mei, L., & Xiong, W.-C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2392 · Cited by 1,030 · see citing works

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

Cárdenas, C., Miller, R. A., Smith, I., Bui, T., Molgó, J., Müller, M., Vais, H., Cheung, K.-H., Yang, J., Parker, I., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.007 · Cited by 1,026 · see citing works

Calcium dyshomeostasis and intracellular signalling in alzheimer's disease

LaFerla, F. M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn960 · Cited by 970 · see citing works

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

Hanger, D. P., Anderton, B. H., & Noble, W. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.01.003 · Cited by 965 · see citing works

Axonal Neuregulin-1 Regulates Myelin Sheath Thickness

Michailov, G. V., Sereda, M. W., Brinkmann, B. G., Fischer, T. M., Haug, B., Birchmeier, C., Role, L. W., Lai, C., Schwab, M. H., & Nave, K. (2004) · Science · doi:10.1126/science.1095862 · Cited by 940 · see citing works

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

Bezprozvanny, I., & Mattson, M. P. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.06.005 · Cited by 938 · see citing works

Calcium as a Coagonist of Inositol 1,4,5-Trisphosphate-Induced Calcium Release

Finch, E., Turner, T. J., & Goldin, S. M. (1991) · Science · doi:10.1126/science.2017683 · Cited by 861 · see citing works

The amyloid hypothesis for Alzheimer’s disease: A critical reappraisal

Hardy, J. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06181.x · Cited by 814 · see citing works

NCLX is an essential component of mitochondrial Na + /Ca 2+ exchange

Palty, R., Silverman, W. F., Hershfinkel, M., Caporale, T., Sensi, S. L., Parnis, J., Nolte, C., Fishman, D., Shoshan‐Barmatz, V., Herrmann, S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908099107 · Cited by 789 · see citing works

Defective Excitation-Contraction Coupling in Experimental Cardiac Hypertrophy and Heart Failure

Gomez, A. M., Valdivia, H. H., Cheng, H., Lederer, M. R., Santana, L. F., Cannell, M. B., McCune, S. A., Altschuld, R. A., & Lederer, W. J. (1997) · Science · doi:10.1126/science.276.5313.800 · Cited by 758 · see citing works

Mitochondrial permeability transition: a common pathway to necrosis and apoptosis

Js, K., He, L., & Lemasters, J. J. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00618-1 · Cited by 756 · see citing works

Abundant Tau Filaments and Nonapoptotic Neurodegeneration in Transgenic Mice Expressing Human P301S Tau Protein

Allen, B., Ingram, E., Takao, M., Smith, M. J., Jakes, R., Virdee, K., Yoshida, H., Holzer, M., Craxton, M., Emson, P. C., et al. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09340.2002 · Cited by 746 · see citing works

Control of Peripheral Nerve Myelination by the ß-Secretase BACE1

Willem, M., Garratt, A. N., Novak, B., Citron, M., Kaufmann, S., Rittger, A., DeStrooper, B., Saftig, P., Birchmeier, C., & Haass, C. (2006) · Science · doi:10.1126/science.1132341 · Cited by 703 · see citing works

Presenilins Form ER Ca2+ Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations

Tu, H., Nelson, O. L., Bezprozvanny, A., Wang, Z., Lee, S.-F., Hao, Y.-H., Serneels, L., Strooper, B. D., Yu, G., & Борисович, Б. И. (2006) · Cell · doi:10.1016/j.cell.2006.06.059 · Cited by 691 · see citing works

Long QT Syndrome

Goldenberg, I., & Moss, A. J. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.02.068 · Cited by 673 · see citing works

Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease

Price, J. L., McKeel, D. W., Buckles, V. D., Roe, C. M., Xiong, C., Grundman, M., Hansen, L. A., Petersen, R. C., Parisi, J. E., Dickson, D. W., et al. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.04.002 · Cited by 661 · see citing works

MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival

Mallilankaraman, K. B., Doonan, P. J., Cárdenas, C., Chandramoorthy, H. C. K., Müller, M., Miller, R., Hoffman, N. E., Gandhirajan, R. K., Molgó, J., Birnbaum, M. J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.10.011 · Cited by 661 · see citing works

Calcium sparks in smooth muscle

Jaggar, J. H., Porter, V. A., Lederer, W. J., & Nelson, M. T. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.278.2.c235 · Cited by 654 · see citing works

Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer Disease<subtitle>A Randomized Controlled Trial</subtitle>

Green, R. C. (2009) · JAMA · doi:10.1001/jama.2009.1866 · Cited by 643 · see citing works

Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer’s disease

Arriagada, P. V., Marzloff, K., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.9.1681 · Cited by 638 · see citing works

Upregulated function of mitochondria‐associated ER membranes in Alzheimer disease

Area‐Gomez, E., del Carmen Lara Castillo, M., Tambini, M. D., Guardia‐Laguarta, C., de Groof, A. J. C., Madra, M., Ikenouchi, J., Umeda, M., Bird, T. D., Sturley, S. L., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.202 · Cited by 638 · see citing works

Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis

Boehning, D. F., Patterson, R. L., Sedaghat, L., Glebova, N. O., Kurosaki, T., & Snyder, S. H. (2003) · Nature Cell Biology · doi:10.1038/ncb1063 · Cited by 636 · see citing works

Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity

Chen, H., Pellegrini, J. W., Aggarwal, S., Lei, S., Warach, S. J., Jensen, F., & Lipton, S. A. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-11-04427.1992 · Cited by 630 · see citing works

Bace1 modulates myelination in the central and peripheral nervous system

Hu, X., Hicks, C. W., He, W., Wong, P., Macklin, W. B., Trapp, B. D., & Yan, R. (2006) · Nature Neuroscience · doi:10.1038/nn1797 · Cited by 608 · see citing works

Increased ER–mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress

Bravo, R., Vicencio, J. M., Parra, V., Troncoso, R., Muñoz, J. P., Bui, M., Quiroga, C., Rodriguez, A. E., Verdejo, H., Ferreira, J., et al. (2011) · Journal of Cell Science · doi:10.1242/jcs.080762 · Cited by 607 · see citing works

Traumatic brain injury and amyloid-β pathology: a link to Alzheimer's disease?

Johnson, V. E., Stewart, W., & Smith, D. H. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2808 · Cited by 587 · see citing works

Clinico‐pathologic studies in dementia: Nondemented subjects with pathologically confirmed Alzheimer's disease

Crystal, H., Dickson, D., Fuld, P., Masur, D., Scott, R., Mehler, M., Masdeu, J., Kawas, C., Aronson, M., & Wolfson, L. (1988) · Neurology · doi:10.1212/wnl.38.11.1682 · Cited by 586 · see citing works

Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

Um, J. W., Kaufman, A. C., Kostylev, M., Heiss, J. K., Stagi, M., Takahashi, H., Kerrisk, M. E., Vortmeyer, A., Wisniewski, T., Koleske, A. J., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.036 · Cited by 572 · see citing works

The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia

Wellcome Trust Case Control Consortium, Green, E. K., Grozeva, D., Jones, I., Jones, L., Kirov, G., Caesar, S., Gordon-Smith, K., Fraser, C., Forty, L., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.49 · Cited by 526 · see citing works

Alzheimer neuropathologic alterations in aged cognitively normal subjects

Davis, D. G., Schmitt, F. A., Wekstein, D. R., & Markesbery, W. R. (1999) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199904000-00008 · Cited by 516 · see citing works

Immunotherapy Targeting Pathological Tau Conformers in a Tangle Mouse Model Reduces Brain Pathology with Associated Functional Improvements

Asuni, A. A., Boutajangout, A., Quartermain, D., & Sigurdsson, E. M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2361-07.2007 · Cited by 506 · see citing works

Mechanism of action of memantine

Johnson, J. M., & Kotermanski, S. E. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.09.007 · Cited by 500 · see citing works

Resolving controversies on the path to Alzheimer's therapeutics

Selkoe, D. J. (2011) · Nature Medicine · doi:10.1038/nm.2460 · Cited by 494 · see citing works

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

Mallilankaraman, K. B., Cárdenas, C., Doonan, P. J., Chandramoorthy, H. C. K., Irrinki, K. M., Golenár, T., Csordás, G., Madireddi, P., Yang, J., Müller, M., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2622 · Cited by 487 · see citing works

Ca2+ transfer from the ER to mitochondria: When, how and why

Rizzuto, R., Marchi, S., Bonora, M., Aguiari, P., Bononi, A., Stefani, D. D., Giorgi, C., Leo, S., Rimessi, A., Siviero, R., et al. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.03.015 · Cited by 479 · see citing works

Modulation of the endoplasmic reticulum–mitochondria interface in Alzheimer’s disease and related models

Hedskog, L., Pinho, C. M., Filadi, R., Rönnbäck, A., Hertwig, L., Wiehager, B., Larssen, P., Gellhaar, S., Sandebring, A., Westerlund, M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300677110 · Cited by 478 · see citing works

Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

Cheung, K., Shineman, D. W., Müller, M., Cárdenas, C., Mei, L., Yang, J., Tomita, T., Iwatsubo, T., Lee, V. M. ‐., & Foskett, J. K. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.015 · Cited by 452 · see citing works

Axonal regulation of myelination by neuregulin 1

Nave, K., & Salzer, J. L. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.08.008 · Cited by 452 · see citing works

The Role of Tau in Alzheimer's Disease and Related Disorders

Medeiros, R., Baglietto‐Vargas, D., & LaFerla, F. M. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00177.x · Cited by 448 · see citing works

Increased NF-Κb Signalling Up-Regulates BACE1 Expression and its Therapeutic Potential in Alzheimer's Disease

Chen, C.-H., Zhou, W., Liu, S., Deng, Y., Cai, F., Tone, M., Tone, Y., Tong, Y., & Song, W. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000149 · Cited by 433 · see citing works

Dihydropyridine receptor mutations cause hypokalemic periodic paralysis

Ptáček, L. J. (1994) · Cell · doi:10.1016/0092-8674(94)90135-x · Cited by 426 · see citing works

Erratum: Corrigenda: MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

Mallilankaraman, K. B., Cárdenas, C., Doonan, P. J., Chandramoorthy, H. C. K., Irrinki, K. M., Golenár, T., Csordás, G., Madireddi, P., Yang, J., Müller, M., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3202 · Cited by 418 · see citing works

Malignant-Hyperthermia Susceptibility Is Associated with a Mutation of the a1-Subunit of the Human Dihydropyridine-Sensitive L-Type Voltage-Dependent Calcium-Channel Receptor in Skeletal Muscle

Monnier, N., Procaccio, V., Stieglitz, P., & Lunardi, J. (1997) · The American Journal of Human Genetics · doi:10.1086/515454 · Cited by 418 · see citing works

Signaling cell death from the endoplasmic reticulum stress response

Shore, G. C., Papa, F. R., & Oakes, S. A. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.11.003 · Cited by 403 · see citing works

Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies

Scheff, S. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.08.002 · Cited by 391 · see citing works

Amyloid Deposition Begins in the Striatum of Presenilin-1 Mutation Carriers from Two Unrelated Pedigrees

Klunk, W. E., Price, J. C., Mathis, C. A., Tsopelas, N. D., Lopresti, B. J., Ziolko, S. K., Bi, W., Hoge, J. A., Cohen, A. D., Ikonomovic, M. D., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0730-07.2007 · Cited by 389 · see citing works

ER Stress and Its Functional Link to Mitochondria: Role in Cell Survival and DeathPreprint

Malhotra, J. D., & Kaufman, R. J. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004424 · Cited by 387 · see citing works

Reimagining Alzheimer's Disease—An Age-Based Hypothesis

Herrup, K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4521-10.2010 · Cited by 386 · see citing works

“Preclinical” AD revisited: Neuropathology of cognitively normal older adults

Schmitt, F. A., Davis, D. G., Wekstein, D. R., Smith, C. D., Ashford, J. W., & Markesbery, W. R. (2000) · Neurology · doi:10.1212/wnl.55.3.370 · Cited by 369 · see citing works

Amyloid β oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors

Alberdi, E. M., Sánchez‐Gómez, M. V., Cavaliere, F., Pérez‐Samartín, A., Zugaza, J. L., Trullás, R., Domercq, M., & Matute, C. (2010) · Cell Calcium · doi:10.1016/j.ceca.2009.12.010 · Cited by 364 · see citing works

Rosiglitazone Monotherapy in Mild-to-Moderate Alzheimer’s Disease: Results from a Randomized, Double-Blind, Placebo-Controlled Phase III Study

Gold, M., Alderton, C., Zvartau-Hind, M., Egginton, S., Saunders, A. M., Irizarry, M., Craft, S., Landreth, G., Linnamägi, Ü., & Sawchak, S. (2010) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000318845 · Cited by 361 · see citing works

Synaptic slaughter in Alzheimer's disease

Coleman, P. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.09.001 · Cited by 351 · see citing works

Dementia Resulting From Traumatic Brain Injury: What Is the Pathology?

Shively, S., Scher, A. I., Perl, D. P., & Diaz-Arrastia, R. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.3747 · Cited by 346 · see citing works

Treatment of Alzheimer's Disease with the GSK-3 Inhibitor Tideglusib: A Pilot Study

del Ser, T., Steinwachs, K. C., Gertz, H. J., Andrés, M. V., Gómez-Carrillo, B., Medina, M., Vericat, J. A., Redondo, P., Fleet, D., & León, T. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-120805 · Cited by 329 · see citing works

Enhanced Ryanodine Receptor Recruitment Contributes to Ca2+Disruptions in Young, Adult, and Aged Alzheimer's Disease Mice

Stutzmann, G. E., Smith, I. F., Caccamo, A., Oddo, S., LaFerla, F. M., & Parker, I. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0739-06.2006 · Cited by 327 · see citing works

A calcium channel mutation causing hypokalemic periodic paralysis

Jurkat‐Rott, K., Lehmann‐Horn, F., Elbaz, A., Heine, R., Gregg, R. G., Hogan, K. J., Powers, P. A., Laple, P., Vale-Santos, J., Weissenbach, J., et al. (1994) · Human Molecular Genetics · doi:10.1093/hmg/3.8.1415 · Cited by 315 · see citing works

Passive immunization targeting pathological phospho‐tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain

Boutajangout, A., Ingadottir, J., Davies, P., & Sigurdsson, E. M. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07337.x · Cited by 306 · see citing works

Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study.

Hampel, H. J., Ewers, M., Bürger, K., Annas, P., Mörtberg, A., Bogstedt, A., Frölich, L., Schröder, J., Schönknecht, P., Riepe, M. W., et al. (2009) · PubMed · Cited by 305 · see citing works

Allosteric Sensitization of Nicotinic Receptors by Galantamine, a New Treatment Strategy for Alzheimer’s Disease

Maelicke, A., Samochocki, M., Jostock, R., Fehrenbacher, A., Ludwig, J., Albuquerque, E. X., & Zerlin, M. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01109-4 · Cited by 303 · see citing works

Lithium Trial in Alzheimer's Disease

Hampel, H. J., Ewers, M., Bürger, K., Annas, P., Mörtberg, A., Bogstedt, A., Frölich, L., Schröder, J., Schönknecht, P., Riepe, M. W., et al. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08m04606 · Cited by 297 · see citing works

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in <i>BACE1</i> -null mice

Savonenko, A. V., Melnikova, T., Laird, F. M., Stewart, K.-A., Price, D. L., & Wong, P. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710373105 · Cited by 290 · see citing works

A caffeine‐ and ryanodine‐sensitive Ca2+ store in bullfrog sympathetic neurones modulates effects of Ca2+ entry on [Ca2+]i.

Friel, D. D., & Tsien, R. W. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019125 · Cited by 284 · see citing works

Amyloid-Independent Mechanisms in Alzheimer's Disease Pathogenesis

Pimplikar, S. W., Nixon, R. A., Robakis, N. K. R. K., Shen, J., & Tsai, L. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4305-10.2010 · Cited by 281 · see citing works

Presenilins are essential for regulating neurotransmitter release

Zhang, C., Wu, B., Beglopoulos, V., Wines-Samuelson, M., Zhang, D., Dragatsis, I., Südhof, T. C., & Shen, J. (2009) · Nature · doi:10.1038/nature08177 · Cited by 280 · see citing works

PPARγ Agonists as Therapeutics for the Treatment of Alzheimer's Disease

Landreth, G. E., Jiang, Q., Mandrekar, S., & Heneka, M. T. (2008) · Neurotherapeutics · doi:10.1016/j.nurt.2008.05.003 · Cited by 277 · see citing works

Lack of Evidence for the Efficacy of Memantine in Mild Alzheimer Disease

Schneider, L. S. S. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.69 · Cited by 276 · see citing works

Immunotherapy Targeting Pathological Tau Prevents Cognitive Decline in a New Tangle Mouse Model

Boutajangout, A., Quartermain, D., & Sigurdsson, E. M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4363-10.2010 · Cited by 272 · see citing works

MCUR1は細胞代謝を制御するミトコンドリアCa 2MCUR1+ 取込の必須成分である

Mallilankaraman, K. B., Cesar, C., Patrick, J., Harish, C. C., Krishna, M. I., Golenár, T., Gyoergy, C., Madireddi, P., Jun, Y., Müller, M., et al. (2012) · Nature Cell Biology · Cited by 270 · see citing works

Neuroprotective and symptomatological action of memantine relevant for alzheimer’s disease — a unified glutamatergic hypothesis on the mechanism of action

Danysz, W., Parsons, C. G., Möbius, H. J., Stöffler, A., & Quack, G. (2000) · Neurotoxicity Research · doi:10.1007/bf03033787 · Cited by 262 · see citing works

The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease

Ilijić, E., Guzmán, J. N., & Surmeier, D. J. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.04.007 · Cited by 260 · see citing works

Synaptic Changes in Alzheimer's Disease

Gylys, K. H., Fein, J. A., Yang, F., Wiley, D. J., Miller, C. A., & Cole, G. M. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63436-0 · Cited by 253 · see citing works

Active and passive immunotherapy for neurodegenerative disorders

Brody, D. L., & Holtzman, D. M. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125529 · Cited by 250 · see citing works

Mitochondrial Ca2+ as a key regulator of cell life and death

Giacomello, M., Drago, I., Pizzo, P., & Pozzan, T. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402147 · Cited by 249 · see citing works

Ryanodine Receptor Blockade Reduces Amyloid-β Load and Memory Impairments in Tg2576 Mouse Model of Alzheimer Disease

Oulès, B., Prete, D. D., Greco, B., Zhang, X., Lauritzen, I., Sévalle, J., Moréno, S., Paterlini-Bréchot, P., Trebak, M., Checler, F., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0875-12.2012 · Cited by 245 · see citing works

The CDK inhibitors in cancer research and therapy

Cicenas, J., & Valius, M. (2011) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-011-1039-4 · Cited by 244 · see citing works

Altered Calcium Signaling Following Traumatic Brain Injury

Weber, J. T. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00060 · Cited by 244 · see citing works

Chapter 37 Selective vulnerability of corticocortical and hippocampal circuits in aging and Alzheimer's disease

Morrison, J. H., & Hof, P. R. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)36039-4 · Cited by 241 · see citing works

Extracellular tau is toxic to neuronal cells

Gómez-Ramos, A., Díaz-Hernández, M., Cuadros, R., Hernández, F., & Avila, J. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.07.078 · Cited by 241 · see citing works

Familial Alzheimer disease–linked mutations specifically disrupt Ca2+ leak function of presenilin 1

Nelson, O. L., Tu, H., Lei, T., Bentahir, M., Strooper, B. D., & Борисович, Б. И. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30447 · Cited by 226 · see citing works

CaV2.1 channelopathies

Pietrobon, D. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0802-8 · Cited by 220 · see citing works

Alzheimer's therapeutics: Continued clinical failures question the validity of the amyloid hypothesis—but what lies beyond?

Mullane, K., & Williams, M. J. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.11.014 · Cited by 212 · see citing works

Deviant Ryanodine Receptor-Mediated Calcium Release Resets Synaptic Homeostasis in Presymptomatic 3xTg-AD Mice

Chakroborty, S., Goussakov, I. V., Miller, M. B., & Stutzmann, G. E. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2047-09.2009 · Cited by 209 · see citing works

Gain-of-Function Enhancement of IP 3 Receptor Modal Gating by Familial Alzheimer’s Disease–Linked Presenilin Mutants in Human Cells and Mouse Neurons

Cheung, K., Mei, L., Mak, D. D., Hayashi, I., Iwatsubo, T., Kang, D. E., & Foskett, J. K. (2010) · Science Signaling · doi:10.1126/scisignal.2000818 · Cited by 208 · see citing works

Recent developments in Alzheimer's disease therapeutics

Rafii, M., & Aisen, P. (2009) · BMC Medicine · doi:10.1186/1741-7015-7-7 · Cited by 204 · see citing works

Mitochondrial dynamics and Ca2+ signaling

Szabadkai, G., Simoni, A. M., Bianchi, K., Stefani, D. D., Leo, S., Wieckowski, M. R., & Rizzuto, R. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.04.002 · Cited by 204 · see citing works

The Pathogenesis of Alzheimers Disease—Is It a Lifelong “Calciumopathy”?

Stutzmann, G. E. (2007) · The Neuroscientist · doi:10.1177/1073858407299730 · Cited by 195 · see citing works

Targeting Phospho-Ser422 by Active Tau Immunotherapy in the THYTau22 Mouse Model: A Suitable Therapeutic Approach

Zommer, N., Sergeant, N., Schraen-Maschke, S., Blum, D., & Buee, L. (2012) · Current Alzheimer Research · doi:10.2174/156720512800492503 · Cited by 193 · see citing works

The role of the endoplasmic reticulum Ca2+ store in the plasticity of central neurons

Bardo, S. J., Cavazzini, M., & Emptage, N. J. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.12.008 · Cited by 188 · see citing works

The endoplasmic reticulum and neuronal calcium signalling

Verkhratsky, A. (2002) · Cell Calcium · doi:10.1016/s0143416002001896 · Cited by 185 · see citing works

Role of Presenilins in Neuronal Calcium Homeostasis

Zhang, H., Sun, S., Herreman, A., Strooper, B. D., & Борисович, Б. И. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1554-10.2010 · Cited by 181 · see citing works

Synaptic Depression and Aberrant Excitatory Network Activity in Alzheimer’s Disease: Two Faces of the Same Coin?

Palop, J. J., & Mucke, L. (2009) · NeuroMolecular Medicine · doi:10.1007/s12017-009-8097-7 · Cited by 177 · see citing works

Single-channel Ca2+ imaging implicates Aβ1–42 amyloid pores in Alzheimer’s disease pathology

Demuro, A., Smith, M., & Parker, I. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201104133 · Cited by 175 · see citing works

Deletion of the ryanodine receptor type 3 (RyR3) impairs forms of synaptic plasticity and spatial learning

Balschun, D., Wolfer, D. P., Bertocchini, F., Barone, V., Conti, A., Zuschratter, W., Missiaen, L., Lipp, H., Frey, J. U., & Sorrentino, V. (1999) · The EMBO Journal · doi:10.1093/emboj/18.19.5264 · Cited by 175 · see citing works

Novel Neuroprotective Mechanisms of Memantine: Increase in Neurotrophic Factor Release from Astroglia and Anti-Inflammation by Preventing Microglial Activation

Wu, H.-M., Tzeng, N., Li, Q., Wei, S., Hu, X., Chen, S., Rawls, S. M., Flood, P. M., Hong, J., & Lu, R. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.64 · Cited by 174 · see citing works

Report of the task force on designing clinical trials in early (predementia) AD

Aisen, P. S. S., Andrieu, S., Sampaio, C., Carrillo, M. C., Khachaturian, Z. S., Dubois, B., Feldman, H., Petersen, R. C., Siemers, E., Doody, R. S., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e318207b1b9 · Cited by 172 · see citing works

Calcium regulation of neural rhythms, memory and Alzheimer's disease

Berridge, M. J. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.257527 · Cited by 172 · see citing works

Facilitation of NMDAR-Independent LTP and Spatial Learning in Mutant Mice Lacking Ryanodine Receptor Type 3

Futatsugi, A., Kato, K., Ogura, H., Li, S., Nagata, E., Kuwajima, G., Tanaka, K., Itohara, S., & Mikoshiba, K. (1999) · Neuron · doi:10.1016/s0896-6273(00)81123-x · Cited by 166 · see citing works

Alzheimer's failure raises questions about disease-modifying strategies

Extance, A. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3288 · Cited by 165 · see citing works

NMDA-Mediated Ca2+Influx Drives Aberrant Ryanodine Receptor Activation in Dendrites of Young Alzheimer's Disease Mice

Goussakov, I. V., Miller, M. B., & Stutzmann, G. E. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2474-10.2010 · Cited by 162 · see citing works

Role of Leaky Neuronal Ryanodine Receptors in Stress- Induced Cognitive Dysfunction

Liu, X., Betzenhauser, M. J., Reiken, S. R., Méli, A. C., Xie, W., Chen, B.-X., Arancio, O., & Marks, A. R. (2012) · Cell · doi:10.1016/j.cell.2012.06.052 · Cited by 161 · see citing works

Localization of the gene encoding the α2/δ-subunits of the L-type voltage-dependent calcium channel to chromosome 7q and analysis of the segregation of flanking markers in malignant hyperthermia susceptible families

Iles, D., Lehmann‐Horn, F., Scherer, S. W., Tsui, L.-C., Weghuis, D. O., Suijkerbuijk, R. F., Heytens, L., Mikala, G., Schwartz, A., ELLIS, F. R., et al. (1994) · Human Molecular Genetics · doi:10.1093/hmg/3.6.969 · Cited by 160 · see citing works

Beneficial effect of human anti-amyloid-β active immunization on neurite morphology and tau pathology

Serrano-Pozo, A., William, C. M., Ferrer, I., Uro-Coste, E., Delisle, M.-B., Maurage, C.-A., Hock, C., Nitsch, R. M., Masliah, E., Growdon, J. H., et al. (2010) · Brain · doi:10.1093/brain/awq056 · Cited by 159 · see citing works

L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease

Anekonda, T. S., Quinn, J. F., Harris, C., Frahler, K., Wadsworth, T. L., & Woltjer, R. L. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.08.020 · Cited by 155 · see citing works

Major channels involved in neuropsychiatric disorders and therapeutic perspectives

Imbrici, P., Camerino, D. C., & Tricarico, D. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00076 · Cited by 148 · see citing works

Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity

Tolar, M., Keller, J. N., Chan, S., Mattson, M. P., Marques, M. A., & Crutcher, K. A. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-16-07100.1999 · Cited by 148 · see citing works

Tau Passive Immunotherapy in Mutant P301L Mice: Antibody Affinity versus Specificity

d’Abramo, C., Acker, C. M., Jimenez, H. T., & Davies, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062402 · Cited by 144 · see citing works

Neuronal Store-Operated Calcium Entry Pathway as a Novel Therapeutic Target for Huntington's Disease Treatment

Wu, J., Shih, H.-P., Vigont, V. A., Hrdlicka, L., Diggins, L. T., Singh, C. M., Mahoney, M. B., Chesworth, R., Shapiro, G., Zimina, O. A., et al. (2011) · Chemistry & Biology · doi:10.1016/j.chembiol.2011.04.012 · Cited by 143 · see citing works

Neuronal P/Q-type calcium channel dysfunction in inherited disorders of the CNS

Rajakulendran, S., Kaski, D. N., & Hanna, M. G. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.228 · Cited by 143 · see citing works

Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation

Crowe, A., James, M. J., Lee, V. M.-Y., Smith, A. B., Trojanowski, J. Q., Ballatore, C., & Brunden, K. R. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.436006 · Cited by 143 · see citing works

Absence of cognitive impairment or decline in preclinical Alzheimer’s disease

Goldman, W. P., Price, J. L., Storandt, M., Grant, E., McKeel, D. W., Rubin, E. H., & Morris, J. C. (2001) · Neurology · doi:10.1212/wnl.56.3.361 · Cited by 143 · see citing works

Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease

Bruno, A. M., Huang, J. Y., Bennett, D. A., Marr, R. A., Hastings, M. L., & Stutzmann, G. E. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.03.011 · Cited by 141 · see citing works

Distribution of inositol-1,4,5-trisphosphate receptor isotypes and ryanodine receptor isotypes during maturation of the rat hippocampus

Hertle, D. N., & Yeckel, M. F. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.09.058 · Cited by 139 · see citing works

Twenty years of Alzheimer’s disease‐causing mutations

Goate, A., & Hardy, J. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07575.x · Cited by 137 · see citing works

Stabilizing ER Ca2+ Channel Function as an Early Preventative Strategy for Alzheimer’s Disease

Chakroborty, S., Briggs, C. A., Miller, M. B., Goussakov, I. V., Schneider, C., Kim, J. S., Wicks, J. M., Richardson, J. C., Conklin, V., Cameransi, B. G., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052056 · Cited by 136 · see citing works

Involvement of ryanodine receptors in neurotrophin-induced hippocampal synaptic plasticity and spatial memory formation

Adasme, T., Haeger, P. A., Paula-Lima, A. C., Espinoza, I., Casas-Alarcón, M. M., Carrasco, M. A., & Hidalgo, C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013580108 · Cited by 135 · see citing works

Cytotoxicity of Intracellular Aβ 42 Amyloid Oligomers Involves Ca 2+ Release from the Endoplasmic Reticulum by Stimulated Production of Inositol Trisphosphate

Demuro, A., & Parker, I. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4367-12.2013 · Cited by 134 · see citing works

Mechanisms Behind the Neuroprotective Actions of Cholinesterase Inhibitors in Alzheimer Disease

Nordberg, A. K. (2006) · Alzheimer Disease & Associated Disorders · doi:10.1097/01.wad.0000213804.59187.2d · Cited by 134 · see citing works

Current progress in beta-amyloid immunotherapy

Schenk, D., Hagen, M., & Seubert, P. A. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2004.07.012 · Cited by 134 · see citing works

Genetic Calcium Signaling Abnormalities in the Central Nervous System: Seizures, Migraine, and Autism

Gargus, J. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.03572.x · Cited by 132 · see citing works

Disease-modifying treatments for Alzheimer’s disease

Galimberti, D., & Scarpini, E. A. (2011) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285611404470 · Cited by 128 · see citing works

Neurological Channelopathies

Kullmann, D. M. (2010) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153122 · Cited by 128 · see citing works

Biphasic Regulation of Mitochondrial Ca2+ Uptake by Cytosolic Ca2+ Concentration

Moreau, B., Nelson, C., & Parekh, A. B. (2006) · Current Biology · doi:10.1016/j.cub.2006.06.059 · Cited by 126 · see citing works

Mechanisms of Ca2+-dependent transcription

Mellström, B., & Naranjo, J. R. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00213-0 · Cited by 124 · see citing works

Hope in Alzheimer's fight emerges from unexpected places

Gura, T. (2008) · Nature Medicine · doi:10.1038/nm0908-894 · Cited by 123 · see citing works

Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer’s disease mice

Chakroborty, S., Kim, J., Schneider, C., Jacobson, C., Molgo, J., & Stutzmann, G. E. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0936-12.2012 · Cited by 118 · see citing works

Enhanced Ryanodine‐Mediated Calcium Release in Mutant PS1‐Expressing Alzheimer's Mouse Models

Stutzmann, G. E., Smith, I. F., Caccamo, A., Oddo, S., Parker, I., & LaFerla, F. M. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1379.025 · Cited by 118 · see citing works

Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice

Peng, J., Liang, G., Inan, S., Wu, Z. F., Joseph, D. J., Meng, Q., Peng, Y., Eckenhoff, M. F., & Wei, H. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.04.008 · Cited by 116 · see citing works

Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons

Wu, B., Yamaguchi, H., Lai, F. A., & Shen, J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304171110 · Cited by 115 · see citing works

Synaptic Plasticity in Hippocampal CA1 Neurons of Mice Lacking Type 1 Inositol-1,4,5-Trisphosphate ReceptorsPreprint

Fujii, S., Matsumoto, M., Igarashi, K., Kato, H., & Mikoshiba, K. (2000) · Learning & Memory · doi:10.1101/lm.34100 · Cited by 111 · see citing works

MGluR-Mediated Calcium Waves that Invade the Soma Regulate Firing in Layer V Medial Prefrontal Cortical Pyramidal Neurons

Hagenston, A. M., Fitzpatrick, J. S., & Yeckel, M. F. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm075 · Cited by 109 · see citing works

Alzheimer disease pathology in cognitively healthy elderly: A genome-wide study

Kramer, P. L., Xu, H., Woltjer, R. L., Westaway, S. K., Clark, D., Erten-Lyons, D., Kaye, J. A., Welsh-Bohmer, K. A., Troncoso, J. C., Markesbery, W. R., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.01.010 · Cited by 108 · see citing works

Role of endoplasmic reticulum Ca2+ signaling in the pathogenesis of Alzheimer disease

Александровна, П. Е., & Борисович, Б. И. (2013) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2013.00029 · Cited by 107 · see citing works

Pathogenesis and Disease-modifying Therapy in Alzheimer's Disease: The Flat Line of Progress

Castellani, R. J., & Perry, G. L. (2012) · Archives of Medical Research · doi:10.1016/j.arcmed.2012.09.009 · Cited by 102 · see citing works

Amyloid-β-(1-42) Increases Ryanodine Receptor-3 Expression and Function in Neurons of TgCRND8 Mice

Supnet, C. B., Grant, J., Kong, H., Westaway, D. A., & Mayne, M. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606736200 · Cited by 100 · see citing works

Apolipoprotein E4 Stimulates cAMP Response Element-binding Protein Transcriptional Activity through the Extracellular Signal-regulated Kinase Pathway

Ohkubo, N., Mitsuda, N., Tamatani, M., Yamaguchi, A., Lee, Y., Ogihara, T., Vitek, M. P., & Tohyama, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005070200 · Cited by 100 · see citing works

Glutamate receptors in preclinical research on Alzheimer's disease: Update on recent advances

Hu, N., Ondrejčák, T., & Rowan, M. J. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.04.013 · Cited by 99 · see citing works

The role of intracellular calcium stores in synaptic plasticity and memory consolidation

Baker, K., Edwards, T. M., & Rickard, N. S. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.04.011 · Cited by 99 · see citing works

The cytosolic N-terminus of presenilin-1 potentiates mouse ryanodine receptor single channel activity

Rybalchenko, V., Hwang, S., Rybalchenko, N., & Koulen, P. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.06.023 · Cited by 99 · see citing works

A preliminary study of the whole-genome expression profile of sporadic and monogenic early-onset Alzheimer's disease

Antonell, A., Lladó, A., Altirriba, J., Botta‐Orfila, T., Balasa, M., Fernández, M., Ferrer, I., Sánchez‐Valle, R., & Molinuevo, J. L. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.12.026 · Cited by 96 · see citing works

Inositol trisphosphate receptor Ca2+ release channels in neurological diseases

Foskett, J. K. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0826-0 · Cited by 95 · see citing works

Role of Genetic Analyses in Cardiology

Priori, S. G., & Napolitano, C. (2006) · Circulation · doi:10.1161/circulationaha.105.563205 · Cited by 95 · see citing works

Support for calcium channel gene defects in autism spectrum disorders

Lu, A. T.-H., Dai, X., Martínez-Agosto, J. A., & Cantor, R. M. (2012) · Molecular Autism · doi:10.1186/2040-2392-3-18 · Cited by 94 · see citing works

Calcium Homeostasis Following Traumatic Neuronal Injury

Weber, J. T. (2004) · Current Neurovascular Research · doi:10.2174/1567202043480134 · Cited by 93 · see citing works

Lack of Evidence for Presenilins as Endoplasmic Reticulum Ca2+ Leak Channels

Shilling, D. J., Mak, D. D., Kang, D. E., & Foskett, J. K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.300491 · Cited by 91 · see citing works

Role of Inositol 1,4,5-Trishosphate Receptors in Pathogenesis of Huntington’s Disease and Spinocerebellar Ataxias

Борисович, Б. И. (2011) · Neurochemical Research · doi:10.1007/s11064-010-0393-y · Cited by 91 · see citing works

CACNA1C Risk Variant and Amygdala Activity in Bipolar Disorder, Schizophrenia and Healthy Controls

Tesli, M., Skåtun, K. C., Ousdal, O. T., Brown, A. A., Thoresen, C., Agartz, I., Melle, I. S., Djurovic, S., Jensen, J., & Andreassen, O. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056970 · Cited by 89 · see citing works

Methylene Blue Reduced Abnormal Tau Accumulation in P301L Tau Transgenic Mice

Hosokawa, M., Arai, T., Masuda‐Suzukake, M., Nonaka, T., Yamashita, M., Akiyama, H., & Hasegawa, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052389 · Cited by 89 · see citing works

Chapter 16 Molecular pathology of head trauma: altered βAPP metabolism and the aetiology of Alzheimer's disease

Gentleman, S. M., Graham, D. I., & Roberts, G. W. (1993) · Progress in brain research · doi:10.1016/s0079-6123(08)63270-7 · Cited by 87 · see citing works

Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP 3 R) Ca 2+ signaling

Müller, M., Cárdenas, C., Mei, L., Cheung, K., & Foskett, J. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109297108 · Cited by 86 · see citing works

Pathogenesis of Abeta Oligomers in Synaptic Failure

Sivanesan, S., Tan, A., & Rajadas, J. (2013) · Current Alzheimer Research · doi:10.2174/1567205011310030011 · Cited by 84 · see citing works

Apoptosis And Calcium: New Roles For Cytochrome c and Inositol 1,4,5-trisphosphate

Boehning, D. F., Patterson, R. L., & Snyder, S. H. (2004) · Cell Cycle · doi:10.4161/cc.3.3.705 · Cited by 83 · see citing works

The point mutation Arg615–>Cys in the Ca2+ release channel of skeletal sarcoplasmic reticulum is responsible for hypersensitivity to caffeine and halothane in malignant hyperthermia

Otsu, K., Nishida, K., Kimura, Y., et al. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36895-3 · Cited by 82 · see citing works

Alzheimer's Disease and Non-Demented High Pathology Control Nonagenarians: Comparing and Contrasting the Biochemistry of Cognitively Successful Aging

Maarouf, C. L., Daugs, I. D., Kokjohn, T. A., Walker, D. G., Hunter, J. M., Kruchowsky, J., Woltjer, R. L., Kaye, J. A., Castaño, E. M., Sabbagh, M. N., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027291 · Cited by 80 · see citing works

Calcium stores and synaptic plasticity

Fitzjohn, S. M., & Collingridge, G. L. (2002) · Cell Calcium · doi:10.1016/s0143416002001999 · Cited by 77 · see citing works

Presenilin 1 regulates homeostatic synaptic scaling through Akt signaling

Pratt, K. G., Zimmerman, E. C., Cook, D. G., & Sullivan, J. (2011) · Nature Neuroscience · doi:10.1038/nn.2893 · Cited by 77 · see citing works

Effects of a Novel Cognitive Enhancer, Spiro[imidazo-[1,2-a]pyridine-3,2-indan]-2(3 H)-one (ZSET1446), on Learning Impairments Induced by Amyloid-β1–40 in the Rat

Yamaguchi, Y., Miyashita, H., Tsunekawa, H., Mouri, A., Kim, H., Saito, K., Matsuno, T., Kawashima, S., & Nabeshima, T. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.098640 · Cited by 77 · see citing works

Genetics and epilepsy

Steinlein, O. K. (2008) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2008.10.1/oksteinlein · Cited by 76 · see citing works

The Role of Aβ-Induced Calcium Dysregulation in the Pathogenesis of Alzheimer's Disease

Small, D. H., Gasperini, R., Vincent, A. J., Hung, A. C., & Foa, L. C. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0951 · Cited by 75 · see citing works

CHF5074, a Novel γ-Secretase Modulator, Restores Hippocampal Neurogenesis Potential and Reverses Contextual Memory Deficit in a Transgenic Mouse Model of Alzheimer's Disease

Imbimbo, B. P., Giardino, L., Sivilia, S., Giuliani, A., Gusciglio, M., Pietrini, V., Giudice, E. D., D’Arrigo, A., Leon, A., Villetti, G., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1366 · Cited by 75 · see citing works

Carvedilol as a potential novel agent for the treatment of Alzheimer's disease

Wang, J., Ono, K., Dickstein, D. L., Arrieta‐Cruz, I., Zhao, W., Qian, X., Lamparello, A. J., Subnani, R., Ferruzzi, M. G., Pavlides, C., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.05.004 · Cited by 73 · see citing works

Modulation of calcium wave propagation in the dendrites and to the soma of rat hippocampal pyramidal neurons

Watanabe, S., Hong, M. Y., Lasser‐Ross, N., & Ross, W. N. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.114231 · Cited by 72 · see citing works

Inhibition of BACE1 for therapeutic use in Alzheimer's disease.

Luo, X., & Yan, R. (2010) · Europe PMC (PubMed Central) · Cited by 71 · see citing works

Disrupted intracellular calcium regulates BACE1 gene expression via nuclear factor of activated T cells 1 (NFAT 1) signaling

Cho, H. J., Jin, S. M., Youn, H., Huh, K., & Mook‐Jung, I. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00360.x · Cited by 71 · see citing works

Mechanisms of AD neurodegeneration may be independent of Aβ and its derivatives

Robakis, N. K. R. K. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.05.022 · Cited by 71 · see citing works

Early calcium dysregulation in Alzheimer’s disease: setting the stage for synaptic dysfunction

Chakroborty, S., & Stutzmann, G. E. (2011) · Science China Life Sciences · doi:10.1007/s11427-011-4205-7 · Cited by 70 · see citing works

Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aβ42 prompted by exogenous fibrillary or soluble Aβ25–35 in human cortical astrocytes and neurons—Therapeutic relevance to Alzheimer's disease

Armato, U., Chiarini, A., Chakravarthy, B., Chioffi, F., Pacchiana, R., Colarusso, E., Whitfield, J. F., & Dal Prà, I. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.04.020 · Cited by 68 · see citing works

Why Did Tarenflurbil Fail in Alzheimer's Disease?

Imbimbo, B. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1092 · Cited by 66 · see citing works

Mutagenesis Mapping of the Presenilin 1 Calcium Leak Conductance Pore

Nelson, O., Supnet, C. B., Tolia, A., Horré, K., Strooper, B. D., & Борисович, Б. И. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.243063 · Cited by 66 · see citing works

From combinations to multitarget-directed ligands: A continuum in Alzheimer’s disease polypharmacology

Albertini, C., Salerno, A., de Sena Murteira Pinheiro, P., & Bolognesi, M. L. (2021) · Medicinal Research Reviews · doi:10.1002/med.21699 · Cited by 179 · see citing works

New Dual Small Molecules for Alzheimer’s Disease Therapy Combining Histamine H ₃ Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition

Malek, R., Arribas, R. L., Palomino-Antolin, A., Totoson, P., Demougeot, C., Kobrlova, T., Soukup, O., Iriepa, I., Moraleda, I., Diez-Iriepa, D., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00937 · Cited by 45 · see citing works

Susquehanna Chorale Spring Concert "Roots and Wings"

Hawkins, D. (2017)

Genentech taps Affimed’s antibodies

Cross, R. (2018) · C&EN Global Enterprise · doi:10.1021/cen-09635-buscon15

KOMPLIKASI REGIONAL ANESTESI PADA PEDIATRIK

Sari, D. (2023) · Jurnal Komplikasi Anestesi · doi:10.22146/jka.v5i1.7322

Enxerto livre de arteria epigastrica inferior: avaliacao hemodinamica e angiografica pre e pos-operatoria

Dib, A., Puig, L. B., Salvadori, D., et al. (1988) · Arquivos Brasileiros de Cardiologia

Interleucinas na encefalopatia hipóxico-isquêmica

Ceccon, M. E. J. R. (2003) · Jornal de Pediatria · doi:10.1590/s0021-75572003000400002 · Cited by 14 · see citing works