Third Generation Cyclodextrin Graft with Polyurethane Embedded in Hydrogel for a Sustained Drug Release: Complete Shrinkage of Melanoma
Abstract
An injectable hydrogel-based drug delivery carrier has been developed for long-term drug release by assembling various generations of cyclodextrin (CD) followed by hydrophobic layers to control the drug release for effective cancer treatment. Three generations of CD are designed through urethane linkages using small spacers to create a large hydrophilic core, which is covered with hydrophobic layers of polyurethane through grafting to maintain the hydrophilic hydrophobic balance of the whole superstructure. Drug release becomes sustained from the intricate superstructure following the non-Fickian diffusion process, resulting in massive cancer cell killing as compared to the low killing rate from the pure drug/material arising from its burst release. The superstructure is found to be a good biomaterial, and its drug-loaded conjugate as a carrier is applied to albino mice to treat their tumors, generated through a melanoma cell line. A drug-embedded superstructure is inoculated in an injectable hydrogel and is placed subcutaneously, below the tumor site, which completely healed the melanoma. No side effect was observed, as opposed to the conventional/control system, due to a sustained drug release from the superstructure as evident from histopathological studies of sensitive body organs and biochemical parameters. Thus, a new design of the vehicle heals the melanoma tumor by enhancing the bioavailability of drug and specific interaction without having any side effects as opposed to conventional chemotherapeutic treatment.
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Sustained release of paclitaxel from the CD superstructure resulted in extensive cancer cell killing compared to low killing from the fast release of the pure drug.
“Sustained release of paclitaxel from this superstructure was observed, as shown in Fig. 8e, which ultimately resulted in extensive cancer cell killing compared to low killing from the fast release of the pure drug.”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [256]
Injectable gel of the CD superstructure, when placed subcutaneously in melanoma mice, showed complete shrinkage, a greater effect than that of the pure drug, and none of the side effects observed in conventional chemotherapy occurred.
“Injectable gel of this superstructure, when placed subcutaneously in melanoma mice, showed complete shrinkage, which has a greater effect than that of the pure drug, and none of the side effects observed in conventional chemotherapy occurred.”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [256]
The biodistribution study showed that the drug was retained for a longer time from Mod-Gel-d while it was rapidly eliminated in the pure form.
“The biodistribution study of the pure drug and gel showed the efficacy of sustained release, since the drug is retained for a longer time period from Mod-Gel-d while it is rapidly eliminated in the pure form as a drug (Fig. 8h).256”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [256]
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Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
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Self-citation
- Authors
- Shukla, A., Singh, A. P., Dubey, T., Hemalatha, S., & Maiti, P.
- Affiliations
- Indian Institute of Technology BHU (IN)
- Corresponding author
- Maiti, Pralay
- Venue
- ACS Applied Bio Materials
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-03-18
- Volume
- 2
- Issue
- 4
- Pages
- 1762-1771
- ISSN
- 2576-6422 (ISSN-L)
- OpenAlex
- W2922260765
- Cited by
- 27
- References
- 44
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 3
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Applied Bio Materials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University Grants Commission
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- polyurethane, injectable hydrogel, sustained drug release, melanoma, tumor shrinkage, non-Fickian diffusion, burst release, hydrophilic-hydrophobic balance, drug carriers
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