The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Magnetic Particle Imaging: A Novel in Vivo Imaging Platform for Cancer Detection
Open accessAbstract
Cancer remains one of the leading causes of death worldwide. Biomedical imaging plays a crucial role in all phases of cancer management. Physicians often need to choose the ideal diagnostic imaging modality for each clinical presentation based on complex trade-offs among spatial resolution, sensitivity, contrast, access, cost, and safety. Magnetic particle imaging (MPI) is an emerging tracer imaging modality that detects superparamagnetic iron oxide (SPIO) nanoparticle tracer with high image contrast (zero tissue background signal), high sensitivity (200 nM Fe) with linear quantitation, and zero signal depth attenuation. MPI is also safe in that it uses safe, in some cases even clinically approved, tracers and no ionizing radiation. The superb contrast, sensitivity, safety, and ability to image anywhere in the body lends MPI great promise for cancer imaging. In this study, we show for the first time the use of MPI for in vivo cancer imaging with systemic tracer administration. Here, long circulating MPI-tailored SPIOs were created and administered intravenously in tumor bearing rats. The tumor was highlighted with tumor-to-background ratio of up to 50. The nanoparticle dynamics in the tumor was also well-appreciated, with initial wash-in on the tumor rim, peak uptake at 6 h, and eventual clearance beyond 48 h. Lastly, we demonstrate the quantitative nature of MPI through compartmental fitting in vivo.
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Cites
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Solving inverse problems using data-driven models
Arridge, S., Maass, P., Öktem, O., & Schönlieb, C.-B. (2019) · Acta Numerica · doi:10.1017/s0962492919000059 · Cited by 686
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Recent progress of magnetic nanoparticles in biomedical applications: A review
Anik, M. I., Hossain, M. K., Hossain, I., Mahfuz, A. M. U. B., Rahman, M. T., & Ahmed, I. (2021) · Nano Select · doi:10.1002/nano.202000162 · Cited by 300
Engineering applications of ferrofluids: A review
Kole, M., & Khandekar, S. (2021) · Journal of Magnetism and Magnetic Materials · doi:10.1016/j.jmmm.2021.168222 · Cited by 283
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Metadata
- Authors
- Yu, E. Y., Bishop, M., Zheng, B., Ferguson, R. M., Khandhar, A. P., Kemp, S. J., Krishnan, K. M., Goodwill, P. W., & Conolly, S. M.
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-02-21
- Volume
- 17
- Issue
- 3
- Pages
- 1648-1654
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W2588306107
- Cited by
- 366
- References
- 45
- FWCI
- 12.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Yu, E. Y., Bishop, M., Zheng, B., Ferguson, R. M., Khandhar, A. P., Kemp, S. J., Krishnan, K. M., Goodwill, P. W., & Conolly, S. M. (2017). Magnetic Particle Imaging: A Novel in Vivo Imaging Platform for Cancer Detection. Nano Letters. https://doi.org/10.1021/acs.nanolett.6b04865
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