The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
BODIPY Derivatives for Photodynamic Therapy: Influence of Configuration versus Heavy Atom Effect
Abstract
Heavy atom effect and configuration are important for BODIPY derivatives to generate singlet oxygen ( 1 O 2 ) for photodynamic therapy. Herein, a series of BODIPY derivatives with different halogens were synthesized. 1 O 2 quantum yields (QYs) and MTT assay confirm that incorporation of more heavy atoms onto dimeric BODIPY cannot effectively enhance the 1 O 2 QYs. Rather, the dark toxicity increases. This phenomenon can be attributed to the competition of heavy atom effect and configuration of dimeric BODIPY. In addition the BODIPY derivative with two iodine atoms (BDPI) owns the highest 1 O 2 QYs (73%) and the lowest phototoxicity IC 50 (1 μM). Furthermore, an in vivo study demonstrates that BDPI NPs can effectively inhibit tumor growth and can be used as a promising threanostic agent for photodynamic therapy in clinic.
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Cites
Fluorescent indicators based on BODIPY
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BODIPY dyes in photodynamic therapy
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Self-citationDesigning Excited States: Theory‐Guided Access to Efficient Photosensitizers for Photodynamic Action
Cakmak, Y., Kolemen, S., Duman, S., Dede, Y., Dolen, Y., Kilic, B., Kostereli, Z., Yildirim, L. T., Dogan, A. L., Guc, D., et al. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201105736 · Cited by 414
Ultralow-Power Near Infrared Lamp Light Operable Targeted Organic Nanoparticle Photodynamic Therapy
Huang, L., Li, Z., Zhao, Y., Zhang, Y., Wu, S., Zhao, J., & Han, G. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b05390 · Cited by 301
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A pH-activatable and aniline-substituted photosensitizer for near-infrared cancer theranostics
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A genetically targetable near-infrared photosensitizer
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Cited by
Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Pham, T. C., Nguyen, V.-N., Choi, Y., Lee, S., & Yoon, J. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00381 · Cited by 1,813
Photosensitizers for Photodynamic Therapy
Lan, M., Zhao, S., Liu, W., Lee, C., Zhang, W., & Wang, P. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900132 · Cited by 1,081
Xiao, Y.-F., Chen, J.-X., Li, S., Tao, W.-W., Tian, S., Wang, K., Cui, X., Huang, Z., Zhang, X.-H., & Lee, C.-S. (2020) · Chemical Science · doi:10.1039/c9sc05817f · Cited by 84
Metadata
- Authors
- Zou, J., Yin, Z., Ding, K., Tang, Q., Li, J., Si, W., Shao, J., Zhang, Q., Huang, W., & Dong, X.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2017-09-13
- Volume
- 9
- Issue
- 38
- Pages
- 32475-32481
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2751401312
- Cited by
- 267
- References
- 27
- FWCI
- 14.58
- Type
- journal article
- Language
- en
- Open access
- closed
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