The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Ultratough, Self-Healing, and Tissue-Adhesive Hydrogel for Wound Dressing
Abstract
A hydrogel for potential applications in wound dressing should possess several peculiar properties, such as efficient self-healing ability and mechanical toughness, so as to repair muscle and skin damage. Additionally, excellent cell affinity and tissue adhesiveness are also necessary for the hydrogel to integrate with the wound tissue in practical applications. Herein, an ultratough and self-healing hydrogel with superior cell affinity and tissue adhesiveness is prepared. The self-healing ability of the hydrogel is obtained through hydrogen bonds and dynamic Schiff cross-linking between dopamine-grafted oxidized sodium alginate (OSA-DA) and polyacrylamide (PAM) chains. The covalent cross-linking is responsible for its stable mechanical structure. The combination of physical and chemical cross-linking contributes to a novel hydrogel with efficient self-healing ability (80% mechanical recovery in 6 h), high tensile strength (0.109 MPa), and ultrastretchability (2550%), which are highly desirable properties and are superior to previously reported tough and self-healing hydrogels for wound dressing applications. More remarkably, due to plenty of catechol groups on the OSA-DA chains, the hydrogel has unique cell affinity and tissue adhesiveness. Moreover, we demonstrate the practical utility of our fabricated hydrogel via both in vivo and in vitro experiments.
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Cites
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Cited by
Functional Hydrogels as Wound Dressing to Enhance Wound Healing
Liang, Y., He, J., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c04206 · Cited by 3,135
Smart wound dressings for wound healing
Dong, R., & Guo, B. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101290 · Cited by 959
Nam, S., & Mooney, D. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00798 · Cited by 764
Mussel-inspired hydrogels: From design principles to promising applications
Zhang, C., Wu, B., Zhou, Y., Zhou, F., Liu, W., & Wang, Z. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00849g · Cited by 653
He, J., Shi, M., Liang, Y., & Guo, B. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.124888 · Cited by 623
Metadata
- Authors
- Chen, T., Chen, Y., Rehman, H. U., Chen, Z., Yang, Z., Wang, M., Li, H., & Liu, H.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-09-11
- Volume
- 10
- Issue
- 39
- Pages
- 33523-33531
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2890322110
- Cited by
- 537
- References
- 42
- FWCI
- 15.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chen, T., Chen, Y., Rehman, H. U., Chen, Z., Yang, Z., Wang, M., Li, H., & Liu, H. (2018). Ultratough, Self-Healing, and Tissue-Adhesive Hydrogel for Wound Dressing. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.8b10064
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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