The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Ultratough, Self-Healing, and Tissue-Adhesive Hydrogel for Wound Dressing
Abstract
A hydrogel for potential applications in wound dressing should possess several peculiar properties, such as efficient self-healing ability and mechanical toughness, so as to repair muscle and skin damage. Additionally, excellent cell affinity and tissue adhesiveness are also necessary for the hydrogel to integrate with the wound tissue in practical applications. Herein, an ultratough and self-healing hydrogel with superior cell affinity and tissue adhesiveness is prepared. The self-healing ability of the hydrogel is obtained through hydrogen bonds and dynamic Schiff cross-linking between dopamine-grafted oxidized sodium alginate (OSA-DA) and polyacrylamide (PAM) chains. The covalent cross-linking is responsible for its stable mechanical structure. The combination of physical and chemical cross-linking contributes to a novel hydrogel with efficient self-healing ability (80% mechanical recovery in 6 h), high tensile strength (0.109 MPa), and ultrastretchability (2550%), which are highly desirable properties and are superior to previously reported tough and self-healing hydrogels for wound dressing applications. More remarkably, due to plenty of catechol groups on the OSA-DA chains, the hydrogel has unique cell affinity and tissue adhesiveness. Moreover, we demonstrate the practical utility of our fabricated hydrogel via both in vivo and in vitro experiments.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
WINTER, G. D. (1962) · Nature · doi:10.1038/193293a0 · Cited by 2,253
Single-molecule mechanics of mussel adhesion
Lee, H., Scherer, N. F., & Messersmith, P. B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605552103 · Cited by 2,112
Physical hydrogels composed of polyampholytes demonstrate high toughness and viscoelasticity
Sun, T. L., Kurokawa, T., Kuroda, S., Ihsan, A. B., Akasaki, T., Sato, K., Haque, M. A., Nakajima, T., & Gong, J. P. (2013) · Nature Materials · doi:10.1038/nmat3713 · Cited by 2,089
Designing Cell-Compatible Hydrogels for Biomedical Applications
Seliktar, D. (2012) · Science · doi:10.1126/science.1214804 · Cited by 1,923
Kamoun, E. A., Kenawy, E.-R. S., & Chen, X. (2017) · Journal of Advanced Research · doi:10.1016/j.jare.2017.01.005 · Cited by 1,707
Mussel-Inspired Adhesives and Coatings
Lee, B. P., Messersmith, P. B., Israelachvili, J. N., & Waite, J. H. (2011) · Annual Review of Materials Research · doi:10.1146/annurev-matsci-062910-100429 · Cited by 1,668
Self-healing polymeric materials
Yang, Y., & Urban, M. W. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60109a · Cited by 1,444
Wound Dressings and Comparative Effectiveness Data
Sood, A., Granick, M. S., & Tomaselli, N. L. (2014) · Advances in Wound Care · doi:10.1089/wound.2012.0401 · Cited by 795
Liao, M., Wan, P., Wen, J., Gong, M., Wu, X., Wang, Y., Shi, R., & Zhang, L. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201703852 · Cited by 760
Gao, H., Sun, Y., Zhou, J., Xu, R., & Duan, H. (2013) · ACS Applied Materials & Interfaces · doi:10.1021/am302500v · Cited by 695
Catechol-functionalized chitosan/pluronic hydrogels for tissue adhesives and hemostatic materials
Ryu, J. H., Lee, Y., Kong, W. H., Kim, T. G., Park, T. G., & Lee, H. (2011) · Biomacromolecules · doi:10.1021/bm200464x · Cited by 677
PVA–clay nanocomposite hydrogels for wound dressing
Kokabi, M., Sirousazar, M., & Hassan, Z. M. (2007) · European Polymer Journal · doi:10.1016/j.eurpolymj.2006.11.030 · Cited by 662
Kamoun, E. A., Chen, X., Mohy Eldin, M. S., & Kenawy, E.-R. S. (2015) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2014.07.005 · Cited by 647
Role of l-3,4-Dihydroxyphenylalanine in Mussel Adhesive Proteins
Yu, M., Hwang, J., & Deming, T. J. (1999) · Journal of the American Chemical Society · doi:10.1021/ja990469y · Cited by 633
Tough, self-healable and tissue-adhesive hydrogel with tunable multifunctionality
Han, L., Yan, L., Wang, K., Fang, L., Zhang, H., Tang, Y., Ding, Y., Weng, L.-T., Xu, J., Weng, J., et al. (2017) · NPG Asia Materials · doi:10.1038/am.2017.33 · Cited by 595
Novel Mussel‐Inspired Injectable Self‐Healing Hydrogel with Anti‐Biofouling Property
Li, L., Yan, B., Yang, J., Chen, L., & Zeng, H. (2015) · Advanced Materials · doi:10.1002/adma.201405166 · Cited by 553
Cross-Linking in Adhesive Quinoproteins: Studies with Model Decapeptides
Burzio, L. A., & Waite, J. H. (2000) · Biochemistry · doi:10.1021/bi0002434 · Cited by 485
Surface-initiated self-healing of polymers in aqueous media
Ahn, B. K., Lee, D. W., Israelachvili, J. N., & Waite, J. H. (2014) · Nature Materials · doi:10.1038/nmat4037 · Cited by 482
Self-Healing Mussel-Inspired Multi-pH-Responsive Hydrogels
Krogsgaard, M., Behrens, M. A., Pedersen, J. S., & Birkedal, H. (2013) · Biomacromolecules · doi:10.1021/bm301844u · Cited by 437
Balakrishnan, B., Joshi, N., Jayakrishnan, A., & Banerjee, R. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.04.031 · Cited by 425
Gong, Z., Zhang, G., Zeng, X., Li, J., Li, G., Huang, W., Sun, R., & Wong, C. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b05627 · Cited by 365
Biological performance of mussel-inspired adhesive in extrahepatic islet transplantation
Brubaker, C. E., Kissler, H., Wang, L.-J., Kaufman, D. B., & Messersmith, P. B. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2009.09.062 · Cited by 322
Mussel-Mimetic Protein-Based Adhesive Hydrogel
Kim, B. J., Oh, D. X., Kim, S., Seo, J. H., Hwang, D. S., Masic, A., Han, D. K., & Cha, H. J. (2014) · Biomacromolecules · doi:10.1021/bm4017308 · Cited by 315
Polysaccharide-based aerogel microspheres for oral drug delivery
García-González, C. A., Jin, M., Gerth, J., Alvarez-Lorenzo, C., & Smirnova, I. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.10.045 · Cited by 296
Self-Healable and Cold-Resistant Supercapacitor Based on a Multifunctional Hydrogel Electrolyte
Tao, F., Qin, L., Wang, Z., & Pan, Q. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b03223 · Cited by 236
Mussel-inspired hyperbranched poly(amino ester) polymer as strong wet tissue adhesive
Zhang, H., Bré, L. P., Zhao, T., Zheng, Y., Newland, B., & Wang, W. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.10.017 · Cited by 232
Tian, R., Qiu, X., Yuan, P., Lei, K., Wang, L., Bai, Y., Liu, S., & Chen, X. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b01740 · Cited by 201
Enzymatically crosslinked alginate hydrogels with improved adhesion properties
Hou, J., Li, C., Guan, Y., Zhang, Y., & Zhu, X. X. (2015) · Polymer Chemistry · doi:10.1039/c4py01757a · Cited by 177
A dynamic and self-crosslinked polysaccharide hydrogel with autonomous self-healing ability
Ding, F., Wu, S., Wang, S., Xiong, Y., Li, Y., Li, B., Deng, H., Du, Y., Xiao, L., & Shi, X. (2015) · Soft Matter · doi:10.1039/c5sm00587f · Cited by 174
Supramolecular Hydrogels Fabricated from Supramonomers: A Novel Wound Dressing Material
Xu, W., Song, Q., Xu, J.-F., Serpe, M. J., & Zhang, X. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b02850 · Cited by 166
Shi, L., Zhao, Y., Xie, Q., Fan, C., Hilborn, J., Dai, J., & Ossipov, D. A. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201700973 · Cited by 162
Monahan, J., & Wilker, J. J. (2004) · Langmuir · doi:10.1021/la0362728 · Cited by 112
Cicco, F. D., Russo, P., Reverchon, E., et al. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2016.04.031 · Cited by 112
Hago, E. E., & Li, X. (2013) · Advances in Materials Science and Engineering · doi:10.1155/2013/328763 · Cited by 100
Effect of Oxidation Rate on Cross-Linking of Mussel Adhesive Proteins
Haemers, S., Koper, G. J. M., & Frens, G. (2003) · Biomacromolecules · doi:10.1021/bm025707n · Cited by 94
In situ sequestration of endogenous PDGF-BB with an ECM-mimetic sponge for accelerated wound healing
Li, Q., Niu, Y., Diao, H., Wang, L., Chen, X., Wang, Y., Dong, L., & Wang, C. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.09.028 · Cited by 92
Ding, F., Shi, X., Wu, S. Z., Liu, X., Deng, H., Du, Y., & Li, H. (2017) · Macromolecular Materials and Engineering · doi:10.1002/mame.201700221 · Cited by 81
Self-citationWang, S., Mo, M., Wang, J., Sadia, S., Shi, B., Fu, X., Yu, L., Tredget, E. E., & Wu, Y. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2641-7 · Cited by 79
Dynamic cell behavior on synthetic hydrogels with different charge densities
Chen, Y. M., Ogawa, R., Kakugo, A., Osada, Y., & Gong, J. P. (2009) · Soft Matter · doi:10.1039/b818586g · Cited by 66
Self-citationWang, X., Jiang, Z., Shi, J., Zhang, C., Zhang, W., & Wu, H. (2013) · Industrial & Engineering Chemistry Research · doi:10.1021/ie401239e · Cited by 66
Development of a Calcium-Chelating Hydrogel for Treatment of Superficial Burns and Scalds
Bullock, A. J., Pickavance, P., Db, H., et al. (2009) · Regenerative Medicine · doi:10.2217/rme.09.67 · Cited by 46
Alegre‐Requena, J. V., Häring, M., Herrera, R. P., & Díaz, D. D. (2016) · New Journal of Chemistry · doi:10.1039/c6nj02367c · Cited by 41
Cited by
Functional Hydrogels as Wound Dressing to Enhance Wound Healing
Liang, Y., He, J., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c04206 · Cited by 3,135
Smart wound dressings for wound healing
Dong, R., & Guo, B. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101290 · Cited by 959
Nam, S., & Mooney, D. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00798 · Cited by 764
Mussel-inspired hydrogels: From design principles to promising applications
Zhang, C., Wu, B., Zhou, Y., Zhou, F., Liu, W., & Wang, Z. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00849g · Cited by 653
He, J., Shi, M., Liang, Y., & Guo, B. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.124888 · Cited by 623
Metadata
- Authors
- Chen, T., Chen, Y., Rehman, H. U., Chen, Z., Yang, Z., Wang, M., Li, H., & Liu, H.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2018-09-11
- Volume
- 10
- Issue
- 39
- Pages
- 33523-33531
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2890322110
- Cited by
- 537
- References
- 42
- FWCI
- 15.12
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
