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Microneedle Patch-Mediated Treatment of Bacterial Biofilms
Open accessAbstract
Current treatments of bacterial biofilms are limited by the poor penetration of antibiotics through their physical barrier as well as significant off-target toxicity of antibiotics and the induction of antibiotic resistance. Here we report a microneedle patch-mediated treatment for the effective elimination of biofilms by penetrating the biofilm and specifically delivering antibiotics to regions of active growth. We fabricated patches with self-dissolvable microneedles and needle tips loaded with chloramphenicol (CAM)-bearing and gelatinase-sensitive gelatin nanoparticles (CAM@GNPs). During the microneedle patch-mediated treatment, arrays of 225 microneedles simultaneously penetrate the biofilm matrix. Once inside, the microneedles dissolve and uniformly release CAM@GNPs into the surrounding area. In response to the gelatinase produced by the active bacterial community, the CAM@GNPs disassemble and release CAM into these active regions of the biofilm. Moreover, CAM@GNPs exhibited minimal off-target toxicity compared to direct CAM administration, which in turn favors wound healing. Importantly, we found that our microneedle-mediated treatment is more effective in treating Vibrio vulnificus biofilms than drug in free solution. We believe this new treatment strategy can be used to improve the delivery of a wide range of antimicrobial agents to biofilm-contaminated sites.
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Drug Delivery Systems: Entering the Mainstream
Allen, T. M., & Cullis, P. R. (2004) · Science · doi:10.1126/science.1095833 · Cited by 4,552
Cell-laden microengineered gelatin methacrylate hydrogels
Nichol, J. W., Koshy, S. T., Bae, H., Hwang, C. M., Yamanlar, S., & Khademhosseini, A. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.064 · Cited by 2,377
Cited by
Lyu, S., Dong, Z., Xu, X., Bei, H.-P., Yuen, H.-Y., James Cheung, C.-W., Wong, M.-S., He, Y., & Zhao, X. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.04.003 · Cited by 266
Wang, Z., Li, B., Nie, C., Zhang, R., Qu, S., Shao, Q., Zhang, X., Li, J., Li, W., Li, H., et al. (2025) · Nano Letters · doi:10.1021/acs.nanolett.4c06284 · Cited by 46
Xu, Y., Chen, B., Xu, L., Zhang, G., Cao, L., Liu, N., Wang, W., Qian, H., & Shao, M. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c17888 · Cited by 35
Song, Y. W., Nam, J., Kim, J., Lee, Y., Choi, J., Min, H. S., Yang, H., Cho, Y., Hwang, S., Son, J., et al. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.122976 · Cited by 33
Metadata
- Authors
- Xu, J., Danehy, R., Cai, H., Ao, Z., Pu, M., Nusawardhana, A., Rowe-Magnus, D., & Guo, F.
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-04-01
- Volume
- 11
- Issue
- 16
- Pages
- 14640-14646
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2934730173
- Cited by
- 174
- References
- 2
- FWCI
- 5.82
- Type
- journal article
- Language
- en
- Open access
- green
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