Cancer Cell Membrane-Biomimetic Nanoplatform for Enhanced Sonodynamic Therapy on Breast Cancer via Autophagy Regulation Strategy
Abstract
Autophagy was considered as a double-edged sword that might cooperate, aggravate, or antagonize apoptosis. We found that the sonodynamic therapy (SDT) in low dosage induced autophagy and might function as a survival pathway for breast cancer and exhibit resistance to SDT-mediated apoptosis. In this sense, it was highly desired to enhance SDT via autophagy regulation strategy. Herein, we reported a biomimetic nanoplatform based on hollow mesoporous titanium dioxide nanoparticles (HMTNPs) by autophagy inhibitor (hydroxychloroquine sulphate, HCQ) loading and cancer cell membrane (CCM) coating. Owing to the biomimetic surface functionalization, the CCM-HMTNPs/HCQ could escape from macrophage phagocytosis, actively recognize and home in on the tumor by homologous targeting ability. Afterward, the released HCQ in response to the ultrasound stimulus was capable of blocking the autophagic flux and cutting off the nutrients supply derived from the damaged organelles, which was anticipated to abrogate the cells' resistance to SDT. Meanwhile, the vessel normalization effect of HCQ alleviated the tumor hypoxia, which was bound to enhance the oxygen-dependent HMTNPs-mediated SDT treatment. Based on the above findings, it was undoubtedly logical that CCM-HMTNPs/HCQ would sensitize breast cancer cells to SDT via autophagy regulation strategy, which held a great promise in cancer treatment.
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The therapeutic effect of SDT can be enhanced by suppressing the increase in autophagy induced by SDT.
“The therapeutic effect of SDT can be enhanced by suppressing the increase in autophagy induced by SDT [43].”
From Nanosensitizer-assisted sonodynamic therapy for breast cancer (2025) · cites this paper as [43]
Hydroxychloroquine alleviated tumor hypoxia through its vascular normalization effect.
“Furthermore, HCQ alleviated tumor hypoxia through its vascular normalization effect.”
From Nanosensitizer-assisted sonodynamic therapy for breast cancer (2025) · cites this paper as [43]
Application of hydroxychloroquine, an autophagy inhibitor, significantly enhanced SDT-induced apoptosis in MCF-7 cells.
“For example, the application of hydroxychloroquine (HCQ), an autophagy inhibitor, significantly enhanced SDT-induced apoptosis in MCF-7 cells [43].”
From Nanosensitizer-assisted sonodynamic therapy for breast cancer (2025) · cites this paper as [43]
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- Authors
- Feng, Q., Yang, X., Hao, Y., Wang, N., Feng, X., Hou, L., & Zhang, Z.
- Affiliations
- Zhengzhou University (CN)
- Shandong University (CN)
- Corresponding author
- Hou, Lin
- Zhang, Zhenzhong
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2019-08-15
- Volume
- 11
- Issue
- 36
- Pages
- 32729-32738
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W2969145594
- Cited by
- 155
- References
- 41
- Citations by year
- 2026: 12 · 2025: 18 · 2024: 22 · 2023: 25 · 2022: 30 · 2021: 20 · 2020: 27 · 2019: 1
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Applied Materials & Interfaces (publishedVersion)
- PubMed (publishedVersion)
- Funders
- China Postdoctoral Science Foundation (2019T120643, 2018M640686)
- National Natural Science Foundation of China (U1704172)
- Key Program for Basic Research of Universities in Henan province (19zx005)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- sonodynamic therapy, breast cancer, autophagy regulation, hydroxychloroquine, cancer cell membrane coating, biomimetic nanoplatform, autophagy inhibition, tumor hypoxia, tumor vasculature normalization, apoptosis resistance
- MeSH terms
- Animals, Autophagy, Breast Neoplasms, Cell Membrane, Female, Humans, Hydroxychloroquine, Mice, Inbred BALB C, Mice, Nude, Titanium, Porosity, Biomimetics, NIH 3T3 Cells, Cell Line, Tumor, Mice, Nanoparticles
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