Elastomeric Trilayer Substrates with Native-like Mechanical Properties for Heart Valve Leaflet Tissue Engineering
Abstract
Heart valve leaflets have a complex trilayered structure with layer-specific orientations, anisotropic tensile properties, and elastomeric characteristics that are difficult to mimic collectively. Previously, trilayer leaflet substrates intended for heart valve tissue engineering were developed with nonelastomeric biomaterials that cannot deliver native-like mechanical properties. In this study, by electrospinning polycaprolactone (PCL) polymer and poly( l -lactide- co -ε-caprolactone) (PLCL) copolymer, we created elastomeric trilayer PCL/PLCL leaflet substrates with native-like tensile, flexural, and anisotropic properties and compared them with trilayer PCL leaflet substrates (as control) to find their effectiveness in heart valve leaflet tissue engineering. These substrates were seeded with porcine valvular interstitial cells (PVICs) and cultured for 1 month in static conditions to produce cell-cultured constructs. The PCL/PLCL substrates had lower crystallinity and hydrophobicity but higher anisotropy and flexibility than PCL leaflet substrates. These attributes contributed to more significant cell proliferation, infiltration, extracellular matrix production, and superior gene expression in the PCL/PLCL cell-cultured constructs than in the PCL cell-cultured constructs. Further, the PCL/PLCL constructs showed better resistance to calcification than PCL constructs. Trilayer PCL/PLCL leaflet substrates with native-like mechanical and flexural properties could significantly improve heart valve tissue engineering.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Elastic three-layer PCL/PLCL lobular substrate prepared by electrospinning has natural tensile, bending and anisotropic properties, better anisotropy and flexibility, and better meets heart valve needs.
“Snyder et al. prepared an elastic three-layer PCL/PLCL lobular substrate with natural tensile, bending and anisotropic properties through electrospinning technology. This composite material has better anisotropy and flexibility, and can better meet the needs of heart valves [172].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [172]
Cites
Mendez, M. G., Kojima, S.-I., & Goldman, R. D. (2010) · The FASEB Journal · doi:10.1096/fj.09-151639 · Cited by 933 · see citing works
Transforming growth factor beta (TGF‐β) isoforms in wound healing and fibrosis
Lichtman, M. K., Otero-Viñas, M., & Falanga, V. (2015) · Wound Repair and Regeneration · doi:10.1111/wrr.12398 · Cited by 635 · see citing works
Scaffolding Strategies for Tissue Engineering and Regenerative Medicine Applications
Pina, S., Ribeiro, V. P., Marques, C. F., Maia, F. R., Silva, T. H., Reis, R. L., & Oliveira, J. M. (2019) · Materials · doi:10.3390/ma12111824 · Cited by 492 · see citing works
On the biomechanics of heart valve function
Sacks, M. S., Merryman, W. D., & Schmidt, D. E. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.05.015 · Cited by 377 · see citing works
Mechanical testing of electrospun PCL fibers
Croisier, F., Duwez, A., Jérôme, C., et al. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2011.08.015 · Cited by 312 · see citing works
Electrospun Polycaprolactone (PCL) Degradation: An In Vitro and In Vivo Study
Dias, J. R., Sousa, A., Augusto, A., Bártolo, P., & Granja, P. L. (2022) · Polymers · doi:10.3390/polym14163397 · Cited by 299 · see citing works
Spectroscopic studies and thermal properties of PCL/PMMA biopolymer blend
Abdelrazek, E. M., Hezma, A. M., El‐Khodary, A., et al. (2015) · Egyptian Journal of Basic and Applied Sciences · doi:10.1016/j.ejbas.2015.06.001 · Cited by 226 · see citing works
Crystalline Morphology of Electrospun Poly(ε-caprolactone) (PCL) Nanofibers
Wang, X., Zhao, H., Turng, L.-S., & Li, Q. (2013) · Industrial & Engineering Chemistry Research · doi:10.1021/ie302185e · Cited by 203 · see citing works
Recent advances in tissue engineering scaffolds based on polyurethane and modified polyurethane
Naureen, B., Haseeb, A. S. M. A., Basirun, W. J., & Muhamad, F. (2021) · Materials Science and Engineering: C · doi:10.1016/j.msec.2020.111228 · Cited by 200 · see citing works
Emmert, M. Y., Schmitt, B., Loerakker, S., Sanders, B., Spriestersbach, H., Fioretta, E. S., Bruder, L., Brakmann, K., Motta, S. E., Lintas, V., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aan4587 · Cited by 186 · see citing works
Kemala, T., Budianto, E., & Soegiyono, B. (2010) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2010.08.003 · Cited by 178 · see citing works
Anisotropic Fibrous Scaffolds for Articular Cartilage Regeneration
McCullen, S. D., Autefage, H., Callanan, A., Gentleman, E., & Stevens, M. M. (2012) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0606 · Cited by 152 · see citing works
Tri-layered elastomeric scaffolds for engineering heart valve leaflets
Masoumi, N., Annabi, N., Assmann, A., Larson, B. L., Hjortnaes, J., Alemdar, N., Kharaziha, M., Manning, K. B., Mayer, J. E., & Khademhosseini, A. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.04.039 · Cited by 152 · see citing works
Materials and manufacturing perspectives in engineering heart valves: a review
Oveissi, F., Naficy, S., Lee, A., Winlaw, D. S., & Dehghani, F. (2019) · Materials Today Bio · doi:10.1016/j.mtbio.2019.100038 · Cited by 141 · see citing works
Ding, Z., Liu, D., Zhao, K., et al. (2021) · Macromolecules · doi:10.1021/acs.macromol.1c00268 · Cited by 141 · see citing works
Dave, K., & Gomes, V. G. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110078 · Cited by 138 · see citing works
Keogh, M. B., O’Brien, F. J., & Daly, J. S. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.06.001 · Cited by 127 · see citing works
Bioresorbable and degradable behaviors of PGA : Current state and future prospects
Low, Y. J., Andriyana, A., Ang, B. C., & Abidin, N. I. Z. (2020) · Polymer Engineering and Science · doi:10.1002/pen.25508 · Cited by 123 · see citing works
Masoumi, N., Larson, B. L., Annabi, N., Kharaziha, M., Zamanian, B., Shapero, K. S., Cubberley, A., Camci‐Unal, G., Manning, K. B., Mayer, J. E., et al. (2014) · Advanced Healthcare Materials · doi:10.1002/adhm.201300505 · Cited by 119 · see citing works
Quinlan, A. M. T., & Billiar, K. L. (2012) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34162 · Cited by 117 · see citing works
Liu, C. A., & Gotlieb, A. I. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080365 · Cited by 104 · see citing works
Porcine cardiac valvular subendothelial cells in culture: Cell isolation and growth characteristics1
JOHNSON, C., HANSON, M., & Helgeson, S. C. (1987) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(87)80529-1 · Cited by 102 · see citing works
Huang, A., Jiang, Y., Napiwocki, B. N., Mi, H., Peng, X., & Turng, L. (2017) · RSC Advances · doi:10.1039/c7ra06987a · Cited by 100 · see citing works
Duan, B., Yin, Z., Kang, L. H., Magin, R. L., & Butcher, J. T. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.03.007 · Cited by 97 · see citing works
Hasan, A., Pattanayek, S. K., & Pandey, L. M. (2018) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b00795 · Cited by 96 · see citing works
The Role of Bone Morphogenetic Protein 7 (BMP-7) in Inflammation in Heart Diseases
Narasimhulu, C. A., & Singla, D. K. (2020) · Cells · doi:10.3390/cells9020280 · Cited by 95 · see citing works
Flaig, F., Ragot, H., Simon, A., Revet, G., Κιτσαρά, Μ., Kitasato, L., Hébraud, A., Agbulut, O., & Schlatter, G. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.0c00243 · Cited by 87 · see citing works
Biodegradable and biomimetic elastomeric scaffolds for tissue-engineered heart valves
Xue, Y., Sant, V. P., Phillippi, J. A., & Sant, S. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.10.032 · Cited by 85 · see citing works
Fabrication and In Vitro Characterization of a Tissue Engineered PCL-PLLA Heart Valve
Hasan, A., Soliman, S. M., Hajj, F. E., Tseng, Y., Yalcin, H. C., & Marei, H. E. S. (2018) · Scientific Reports · doi:10.1038/s41598-018-26452-y · Cited by 82 · see citing works
Dargaville, B. L., Vaquette, C., Rasoul, F. A., Cooper-White, J. J., Campbell, J. H., & Whittaker, A. K. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.02.009 · Cited by 81 · see citing works
Tissue Non-Specific Alkaline Phosphatase and Vascular Calcification: A Potential Therapeutic Target
Azpiazu, D., Gonzálo, S., & Villa‐Bellosta, R. (2018) · Current Cardiology Reviews · doi:10.2174/1573403x14666181031141226 · Cited by 76 · see citing works
Cell contact guidance via sensing anisotropy of network mechanical resistance
Thrivikraman, G., Jagiełło, A., Lai, V. K., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2024942118 · Cited by 74 · see citing works
Strategies for development of decellularized heart valve scaffolds for tissue engineering
Snyder, Y., & Jana, S. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121675 · Cited by 72 · see citing works
Self-citationWang, Q., Ma, Z., Wang, Y., Zhong, L., & Xie, W. (2020) · Bio-Design and Manufacturing · doi:10.1007/s42242-020-00095-3 · Cited by 71 · see citing works
Ehtesabi, H., & Massah, F. (2021) · Materials Today Sustainability · doi:10.1016/j.mtsust.2021.100075 · Cited by 70 · see citing works
Epidemiology of Valvular Heart Disease
Peters, A. S., Duggan, J. P., Trachiotis, G. D., & Antevil, J. L. (2022) · Surgical Clinics of North America · doi:10.1016/j.suc.2022.01.008 · Cited by 69 · see citing works
Uiterwijk, M., Smits, A. I. P. M., van Geemen, D., et al. (2020) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2020.09.011 · Cited by 68 · see citing works
Islam, A., Younesi, M., Mbimba, T., & Akkuş, O. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600284 · Cited by 65 · see citing works
Role of Anisotropy in Tissue Engineering
Mitchell, G. R., & Tojeira, A. (2013) · Procedia Engineering · doi:10.1016/j.proeng.2013.05.100 · Cited by 61 · see citing works
Robust Generation of Quiescent Porcine Valvular Interstitial Cell Cultures
Porras, A. M., van Engeland, N. C. A., Marchbanks, E., McCormack, A. M., Bouten, C. V. C., Yacoub, M. H., Latif, N., & Masters, K. S. B. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.005041 · Cited by 57 · see citing works
Birhanu, G., Javar, H. A., Seyedjafari, E., Zandi‐Karimi, A., & Telgerd, M. D. (2017) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2017.1367928 · Cited by 55 · see citing works
Park, J. H., Lee, B. R., Park, S., Kim, M. G., Lee, J., Lee, J., Lee, H. Y., Kim, J., & Kim, J. I. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030671 · Cited by 53 · see citing works
Arbade, G. K., Srivastava, J. P., Tripathi, V., Lenka, N., & Patro, T. U. (2020) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2020.1769799 · Cited by 52 · see citing works
Chor, A., Gonçalves, R. P., Costa, A. M., Farina, M., Ponche, A., Sirelli, L., Schrodj, G., Grée, S., de Andrade, L. R., Anselme, K., et al. (2020) · Polymers · doi:10.3390/polym12081853 · Cited by 52 · see citing works
Laurent, C. P., Vaquette, C., Liu, X., Schmitt, J.-F., & Rahouadj, R. (2018) · Journal of Biomaterials Applications · doi:10.1177/0885328218757064 · Cited by 49 · see citing works
Xu, C., Yepez, G., Wei, Z., Liu, F., Bugarin, A., & Hong, Y. (2016) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35765 · Cited by 48 · see citing works
Fioretta, E. S., Lintas, V., Mallone, A., Motta, S. E., von Boehmer, L., Dijkman, P. E., Cesarovic, N., Caliskan, E., Biefer, H. R. C., Lipiski, M., et al. (2019) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2019.09.008 · Cited by 48 · see citing works
Cadherin-11 as a regulator of valve myofibroblast mechanobiology
Bowler, M. A., Bersi, M. R., Ryzhova, L., Jerrell, R. J., Parekh, A., & Merryman, W. D. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00277.2018 · Cited by 46 · see citing works
Mechanical enhancement of nanofibrous scaffolds through polyelectrolyte complexation
Xu, J., Cai, N., Wei-xiu, X., Xue, Y., Wang, Z., Dai, Q., & Yu, F. (2012) · Nanotechnology · doi:10.1088/0957-4484/24/2/025701 · Cited by 43 · see citing works
Al-shammari, A. K., & Al‐Bermany, E. (2022) · Journal of Polymer Research · doi:10.1007/s10965-022-03210-3 · Cited by 43 · see citing works
Gupta, V., Tseng, H., Lawrence, B. D., et al. (2008) · Acta Biomaterialia · doi:10.1016/j.actbio.2008.10.009 · Cited by 42 · see citing works
Cardiovascular tissue engineering: From basic science to clinical application
Fioretta, E. S., von Boehmer, L., Motta, S. E., Lintas, V., Hoerstrup, S. P., & Emmert, M. Y. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.03.022 · Cited by 42 · see citing works
Groth, T., & Altankov, G. (1996) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856295x00337 · Cited by 41 · see citing works
Cell size, cell cycle, and α-smooth muscle actin expression by primary human lung fibroblasts
Uhal, B. D., Ramos, C., Joshi, I., et al. (1998) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1998.275.5.l998 · Cited by 41 · see citing works
Effect of crystallinity and related surface properties on gene expression of primary fibroblasts
Kołbuk, D., Ciechomska, M., Jeznach, O., et al. (2022) · RSC Advances · doi:10.1039/d1ra07237d · Cited by 41 · see citing works
Nooeaid, P., Li, W., Roether, J. A., et al. (2014) · Biointerphases · doi:10.1116/1.4897217 · Cited by 39 · see citing works
Influence of physico-mechanical properties of elastomeric material for different cell growth
Wala, J., Maji, D., & Das, S. K. (2017) · Biomedical Materials · doi:10.1088/1748-605x/aa7e81 · Cited by 35 · see citing works
Haim Zada, M., Kumar, A., Elmalak, O., Markovitz, E., Icekson, R., & Domb, A. J. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118870 · Cited by 33 · see citing works
Wu, S., Li, Y., Zhang, C., et al. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202200053 · Cited by 33 · see citing works
Transforming Growth Factor-β Regulates the Growth of Valve Interstitial Cells in Vitro
Li, C., & Gotlieb, A. I. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.06.007 · Cited by 32 · see citing works
Pluronic F127 blended polycaprolactone scaffolds via e-jetting for esophageal tissue engineering
Wu, B., Takeshita, N., Wu, Y. B., Vijayavenkataraman, S., Ho, K. Y., Lu, W. F., & Fuh, J. Y. H. (2018) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-018-6148-z · Cited by 32 · see citing works
Jana, S., & Lerman, A. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.12.005 · Cited by 31 · see citing works
Self-citationEvaluation of canine 2D cell cultures as models of myxomatous mitral valve degeneration
Tan, K. A. L., Markby, G. R., Muirhead, R. H., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0221126 · Cited by 28 · see citing works
Structure-property relationships in 3D-printed poly(l-lactide-co-ε-caprolactone) degradable polymer
Bachtiar, E. O., Ritter, V. C., & Gall, K. (2021) · Journal of the Mechanical Behavior of Biomedical Materials · doi:10.1016/j.jmbbm.2021.104650 · Cited by 27 · see citing works
Jana, S., Franchi, F., & Lerman, A. (2019) · Biomedical Materials · doi:10.1088/1748-605x/ab52e2 · Cited by 26 · see citing works
Self-citationValve leaflet‐inspired elastomeric scaffolds with tunable and anisotropic mechanical properties
Xue, Y., Ravishankar, P., C., M. A. Z., et al. (2019) · Polymers for Advanced Technologies · doi:10.1002/pat.4750 · Cited by 25 · see citing works
Cao, Y., Jiang, J., Jiang, Y., Li, Z., Hou, J., & Li, Q. (2022) · Polymers for Advanced Technologies · doi:10.1002/pat.5528 · Cited by 25 · see citing works
Liu, Z., Wang, Y., Liu, F., Zhu, D., Chen, Y., Yim, W. Y., Hu, K., Rao, Z., Pan, X., Li, F., et al. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155337 · Cited by 24 · see citing works
Mikes, P., Horakova, J., Saman, A., Vejsadova, L., Topham, P., Punyodom, W., Dumklang, M., & Jencova, V. (2021) · Journal of Industrial Textiles · doi:10.1177/1528083719848155 · Cited by 22 · see citing works
Pedrazzo, A. R., Cecone, C., Morandi, S., et al. (2021) · Polymers · doi:10.3390/polym13060977 · Cited by 21 · see citing works
Balancing Degradability and Physical Properties of Amorphous Poly( d,l ‐lactide) by Making Blends
Kumar, A., Weig, A. R., & Agarwal, S. (2021) · Macromolecular Materials and Engineering · doi:10.1002/mame.202100602 · Cited by 20 · see citing works
Ali, M. S., Deb, N., Wang, X., et al. (2018) · Tissue and Cell · doi:10.1016/j.tice.2018.07.004 · Cited by 19 · see citing works
Snyder, Y., & Jana, S. (2022) · Biomedical Materials · doi:10.1088/1748-605x/ac94ae · Cited by 19 · see citing works
Self-citationHyaluronic acid regulates heart valve interstitial cell contraction in fibrin-based scaffolds
Lei, Y. F., Bortolin, L., Benesch, F., et al. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.09.046 · Cited by 18 · see citing works
Shin, M. D., Hochberg, J. D., Pokorski, J. K., et al. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c13183 · Cited by 17 · see citing works
Fibrous heart valve leaflet substrate with native-mimicked morphology
Jana, S., Franchi, F., & Lerman, A. (2021) · Applied Materials Today · doi:10.1016/j.apmt.2021.101112 · Cited by 16 · see citing works
Self-citationIn vivo Tissue Engineering of a Trilayered Leaflet-Shaped Tissue Construct
Jana, S., & Lerman, A. (2020) · Regenerative Medicine · doi:10.2217/rme-2019-0078 · Cited by 13 · see citing works
Self-citationThe rotational position of the aortic valve: implications for valve-sparing aortic root replacement
Oishi, K., Arai, H., Oi, K., et al. (2022) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezac179 · Cited by 13 · see citing works
Xu, X., Liu, J., Sheng, G., et al. (2018) · Applied Surface Science · doi:10.1016/j.apsusc.2018.04.243 · Cited by 12 · see citing works
Engineered microenvironment for the study of myofibroblast mechanobiology
Xu, Y. D., Koya, R. C., Ask, K., & Zhao, R. (2021) · Wound Repair and Regeneration · doi:10.1111/wrr.12955 · Cited by 12 · see citing works
Maleki, F., Jafari, H., Ghaffari‐Bohlouli, P., Shahrousvand, M., Sadeghi, G. M. M., Alimoradi, H., & Shavandi, A. (2021) · Chemical Papers · doi:10.1007/s11696-021-01774-w · Cited by 12 · see citing works
Jana, S., Morse, D. W., & Lerman, A. (2021) · ACS Applied Bio Materials · doi:10.1021/acsabm.1c00768 · Cited by 11 · see citing works
Self-citationTrilayer scaffold with cardiosphere‐derived cells for heart valve tissue engineering
Chen, Q., Bruyneel, A. A. N., Carr, C. A., et al. (2019) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.34427 · Cited by 10 · see citing works
Gerdisch, M., Sathyamoorthy, M., & Michelena, H. I. (2022) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2022.06.001 · Cited by 10 · see citing works
Heterogeneous adhesion of cells on polymer surfaces with underlying amorphous/crystalline phases
Matsuno, H., Irie, S., Hirata, T., et al. (2018) · Journal of Materials Chemistry B · doi:10.1039/c7tb03250a · Cited by 8 · see citing works
Gjerde, N., Zhu, K., Knudsen, K. D., et al. (2019) · European Polymer Journal · doi:10.1016/j.eurpolymj.2019.01.033 · Cited by 8 · see citing works
Investigation of transcriptional changes underlying calcification of aortic valve
Semenova, D., Zabirnyk, A., Lobov, A. A., et al. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac066.140 · Cited by 4 · see citing works
Advances in cardiovascular research
Steckelings, U. M., Mey, J. G. R. D., Pinto‐Sietsma, S., et al. (2010) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.10.178 · Cited by 3 · see citing works
Ismail, Y. M. B., Reinwald, Y., Wimpenny, I., et al. (2018) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1082/1/012072 · Cited by 2 · see citing works
Tagzirt, M., Sottejeau, Y., Kabdani, S., Mickael, R., Corseaux, D., Juthier, F., Vincentelli, A., BELLE, E. V., Jashari, R., Staels, B., et al. (2019) · Archives of Cardiovascular Diseases Supplements · doi:10.1016/j.acvdsp.2019.02.143 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Application of PLCL as a biodegradable polymer in biomedical engineering
Zhao, Y., & Liu, H. (2026) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-026-07016-3 · Cited by 7 · see citing works
- Authors
- Snyder, Y., & Jana, S.
- Affiliations
- University of Missouri (US)
- Corresponding author
- Jana, Soumen
- ORCID
- Jana, Soumen
- Venue
- ACS Biomaterials Science & Engineering
- Publisher
- American Chemical Society (ACS)
- Published
- 2023-02-20
- Volume
- 9
- Issue
- 3
- Pages
- 1570-1584
- ISSN
- 2373-9878 (ISSN-L)
- OpenAlex
- W4321369055
- Cited by
- 15
- References
- 90
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 5 · 2023: 2
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Biomaterials Science & Engineering (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R00HL134823)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- polycaprolactone, poly(L-lactide-co-ε-caprolactone), electrospinning, mechanical anisotropy, calcification resistance, extracellular matrix synthesis, cell proliferation
- MeSH terms
- Animals, Aortic Valve, Aortic Valve Stenosis, Calcinosis, Cells, Cultured, Polymers, Swine, Tissue Engineering, Tissue Scaffolds
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
