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Cited by 180Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionAdvanced Memory and Neural Computing

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Electrical Compartmentalization in Dendritic Spines

Yuste, Rafael·2013·Annual Review of Neuroscience
DOI 10.1146/annurev-neuro-062111-150455
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Abstract

Most excitatory inputs in the CNS contact dendritic spines, avoiding dendritic shafts, so spines must play a key role for neurons. Recent data suggest that, in addition to enhancing connectivity and isolating synaptic biochemistry, spines can behave as electrical compartments independent from their parent dendrites. It is becoming clear that, although spines experience voltages similar to those of dendrites during action potentials (APs), spines must sustain higher depolarizations than do dendritic shafts during excitatory postsynaptic potentials (EPSPs). Synaptic potentials are likely amplified at the spine head and then reduced as they invade the dendrite through the spine neck. These electrical changes, probably due to a combination of passive and active mechanisms, may prevent the saturation of dendrites by the joint activation of many inputs, influence dendritic integration, and contribute to rapid synaptic plasticity. The electrical properties of spines could enable neural circuits to harness a high connectivity, implementing a "synaptic democracy," where each input can be individually integrated, tallied, and modified in order to generate emergent functional states.

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Metadata

Authors
Yuste, R.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
Yuste, Rafael
ORCID
Yuste, Rafael
Venue
Annual Review of Neuroscience
Publisher
Annual Reviews
Published
2013-07-08
Volume
36
Issue
1
Pages
429-449
ISSN
  • 0147-006X (ISSN-L)
  • 1545-4126
DOI
10.1146/annurev-neuro-062111-150455
OpenAlex
W2149246533
Cited by
180
References
128
Citations by year
2026: 10 · 2025: 5 · 2024: 9 · 2023: 15 · 2022: 13 · 2021: 16 · 2020: 13 · 2019: 22 · 2018: 9 · 2017: 16 · 2016: 13 · 2015: 22 · 2014: 16 · 2013: 1
FWCI
1.76
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (R01MH101218)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Physical Sciences › Engineering › Electrical and Electronic Engineering › Advanced Memory and Neural Computing
Keywords
dendritic spines, dendritic integration, excitatory postsynaptic potentials, action potential, synaptic potentials, synaptic plasticity, dendritic excitability
MeSH terms
Action Potentials, Animals, Central Nervous System, Dendrites, Humans, Models, Neurological, Neurons, Dendritic Spines, Synaptic Potentials

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