Novel NIR-II 3,5-Julolidinyl aza-BODIPY for Photothermal Therapy of Gliomas Stem Cells by Brain Stereotactic Injection
Abstract
Functional dyes with absorption in the second near-infrared window (NIR-II) show great promise in photothermal therapy. Herein, the novel NIR-II 3,5-julolidinyl aza-BODIPY ( JLD ) was prepared and confirmed by X-ray crystallographic analysis for the first time. The molecular packing structure facilitates the J -aggregation packing mode. Self-assembled JLD -nanoparticles ( JLD -NPs) emit fluorescence (λ em = 962 nm, Φ f = 0.1%), and a peak belt covered a NIR-II range of 900–1300 nm. The photothermal conversion efficiency was high and was calculated to be 79%. JLD -NPs with NIR-II 915 nm laser irradiation had the good tumor-inhibition capability with promoting the apoptosis and inhibiting the stemness of glioblastoma cells by brain stereotactic injection and affect the occurrence of malignant events, such as migration and invasion.
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- Authors
- Cao, L., Cui, Z., Zhang, D., Li, Y., Gao, X., Shang, R., Jiang, X.-D., Du, J., & Sun, X.
- Affiliations
- Shenyang University of Chemical Technology (CN)
- Fourth Affiliated Hospital of China Medical University (CN)
- Dalian University of Technology (CN)
- Hiroshima University (JP)
- Corresponding author
- Shang, Rong
- Jiang, Xin-Dong
- Sun, Xiaohong
- Venue
- ACS Materials Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2024-09-20
- Volume
- 6
- Issue
- 10
- Pages
- 4765-4773
- ISSN
- 2639-4979 (ISSN-L)
- OpenAlex
- W4402672542
- Cited by
- 18
- References
- 55
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 1
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Materials Letters (publishedVersion)
- Funders
- Shenyang University of Chemical Technology (2021JH13/10200018, 21-104-0-23)
- China Medical University (2022JH2/20200063, 2023JH2/20200162)
- National Natural Science Foundation of China (22078201, U1908202)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Keywords
- NIR-II fluorescence, BODIPY, photothermal therapy, glioma stem cells, glioblastoma, J-aggregation, nanoparticle self-assembly, photothermal conversion efficiency, apoptosis, tumor cell migration and invasion, molecular packing
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