Photophysical Properties of Indocyanine Green in the Shortwave Infrared Region
Open accessAbstract
With the growing development of new contrast agents for optical imaging using near‐infrared and shortwave infrared (SWIR) wavelengths, it is essential to have consistent benchmarks for emitters in these regions. Indocyanine green (ICG), a ubiquitous and FDA‐approved organic dye and optical imaging agent, is commonly employed as a standard for photophysical properties and biological performance for imaging experiments at these wavelengths. Yet, its reported photophysical properties across organic and aqueous solvents vary greatly in the literature, which hinders its ability to be used as a consistent benchmark. Herein, we measure photophysical properties in organic and aqueous solvents using InGaAs detection (∼950–1,700 nm), providing particular relevance for SWIR imaging.
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Indocyanine green (ICG) has measurable long-tail fluorescence emission that stretches to 1500 nm in the SWIR region.
“Recently, the spectroscopic characterization of NIR indocyanine green dye (ICG) revealed measurable long-tail fluorescence emission that stretches to 1500 nm in the SWIR region.28,29”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [28]
The Introduction describes ICG’s emission tail as extending into the SWIR region, and Results and Discussion (SWIR Brightness Comparisons) reports measurable emission through a 1,300 nm longpass filter. Our copy does not establish measurable fluorescence specifically at 1,500 nm; Photophysical Characterization says fluorescence beyond 1,350 nm was minimal. (LLM, conf=0.82)
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- Authors
- Cosco, E. D., Lim, I., & Sletten, E. M.
- Affiliations
- California NanoSystems Institute (US)
- Corresponding author
- Sletten, Ellen M.
- Venue
- ChemPhotoChem
- Publisher
- Wiley
- Published
- 2021-05-19
- Volume
- 5
- Issue
- 8
- Pages
- 727-734
- ISSN
- 2367-0932 (ISSN-L)
- PMC
- PMC8423351
- OpenAlex
- W3157427395
- Cited by
- 79
- References
- 69
- Citations by year
- 2026: 17 · 2025: 17 · 2024: 14 · 2023: 15 · 2022: 14 · 2021: 2
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- ChemPhotoChem (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation (NSF GFRP DGE-1144087)
- National Institutes of Health (1R01EB027172, 1S10OD016387)
- Alfred P. Sloan Foundation (FG-2018-10855)
- University of California, Los Angeles
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Photochemistry and Electron Transfer Studies
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Keywords
- indocyanine green, photophysical properties, shortwave infrared, near-infrared contrast agents, optical imaging
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