Cited by 386Optical Imaging and Spectroscopy TechniquesTraumatic Brain Injury and Neurovascular DisturbancesMolecular Sensors and Ion Detection

Traumatic Brain Injury Imaging in the Second Near‐Infrared Window with a Molecular Fluorophore

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Zhang, Xiao‐Dong, Wang, Huasen, Antaris, Alexander L., Li, Lulin, Diao, Shuo, Ma, Rui, Nguyen, Andy, Hong, Guosong +8 more·2016·Advanced Materials

Abstract

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. A bright, renal-excreted, and biocompatible near-infrared II fluorophore for in vivo imaging of TBI is designed. A transient hypoperfusion in the injured cerebral region, followed by fluorophore leakage, is observed. NIR-II fluorophores can provide noninvasive assessment of TBI.

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Research works printed but not linked: 2

  1. [11]a) Wang R Li X Zhou L Zhang F Angew Chem Int Ed 2014 126 12282 b) Bardhan NM Ghosh D Belcher AM Nat Commun 2014 5 4918 25230005 PMC4349414
  2. [26]Shlosberg D Benifla M Kaufer D Friedman A Nat Rev Neurol 2010 6 393 20551947 PMC3625732

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Authors
Zhang, X., Wang, H., Antaris, A. L., Li, L., Diao, S., Ma, R., Nguyen, A., Hong, G., Ma, Z., Wang, J., Zhu, S., Castellano, J. M., Wyss‐Coray, T., Liang, Y., Luo, J., & Dai, H.
Affiliations
  • Department of Chemistry Stanford University Stanford CA 94305 USA
  • Southern University of Science and Technology (CN)
  • Stanford University (US)
  • VA Palo Alto Health Care System (US)
  • Stanford Medicine (US)
Corresponding author
  • Liang, Yongye
  • Luo, Jian
  • Dai, Hongjie
Venue
Advanced Materials
Publisher
Wiley
Published
2016-06-02
Volume
28
Issue
32
Pages
6872-6879
ISSN
  • 0935-9648 (ISSN-L)
  • 1521-4095
OpenAlex
W2416606193
Cited by
386
References
61
Citations by year
2026: 13 · 2025: 32 · 2024: 35 · 2023: 37 · 2022: 47 · 2021: 50 · 2020: 52 · 2019: 44 · 2018: 45 · 2017: 28 · 2016: 2
FWCI
34.41
Type
journal article
Language
en
Open access
Locations
  • Advanced Materials (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Natural Science Foundation of China (81471786)
  • National Institutes of Health (NS092868)
  • South University of Science and Technology of China (FRG‐SUSTC1501A‐62)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
Keywords
traumatic brain injury, molecular fluorophores, renal excretion, cerebral hypoperfusion, in vivo imaging, non-invasive diagnosis
MeSH terms
Brain Injuries, Traumatic, Animals, Disease Models, Animal, Fluorescent Dyes, Mice

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