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Virus-Mimetic Extracellular-Vesicle Vaccine Boosts Systemic and Mucosal Immunity via Immune Recruitment

Li, Jingru, Xing, Haonan, Meng, Fan, Liu, Ting, Hong, Xiaoxuan, Han, Xiaolu, Dong, Yuhan, Li, Meng, Wang, Zengming, Zhang, Shuang, Cui, Chunying, Zheng, Aiping·2024·ACS Nano
DOI 10.1021/acsnano.4c01277
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Abstract

Mucosal vaccines can prevent viruses from infecting the respiratory mucosa, rather than only curtailing infection and protecting against the development of disease symptoms. The SARS-CoV-2 spike receptor-binding domain (RBD) is a compelling vaccine target but is undermined by suboptimal mucosal immunogenicity. Here, we report a SARS-CoV-2-mimetic extracellular-vesicle vaccine developed using genetic engineering and dendritic cell membrane budding. After mucosal immunization, the vaccine recruits antigen-presenting cells rapidly initiating a strong innate immune response. Notably, it obviates the need for adjuvants and can induce germinal center formation through both intramuscular and intratracheal vaccination. It not only elicits high levels of RBD-specific antibodies but also stimulates extensive cellular immunity in the respiratory mucosa. A sequential immunization strategy, starting with an intramuscular injection followed by an intratracheal booster, significantly bolsters mucosal immunity with high levels of IgA and tissue-resident memory T cell responses, thereby establishing a formidable defense against pseudovirus infection.

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Crossref · 10.1021/acsnano.4c01277

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Metadata

Authors
Li, J., Xing, H., Meng, F., Liu, T., Hong, X., Han, X., Dong, Y., Li, M., Wang, Z., Zhang, S., Cui, C., & Zheng, A.
Venue
ACS Nano
Publisher
American Chemical Society (ACS)
Published
2024-07-16
ISSN
  • 1936-0851
  • 1936-086X
DOI
10.1021/acsnano.4c01277
Cited by
2
References
7
Language
en
Licence
Funders
  • National Key Research and Development Program of China (2023YFC2605000)
  • China Postdoctoral Science Foundation (2021M693966)
  • National Natural Science Foundation of China (32101157, 32371440, 81573357)

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