The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A Near-Infrared Triggered Nanophotosensitizer Inducing Domino Effect on Mitochondrial Reactive Oxygen Species Burst for Cancer Therapy
Abstract
Photodynamic therapy (PDT) is a well-established modality for cancer therapy, which locally kills cancer cells when light irradiates a photosensitizer. However, conventional PDT is often limited by the extremely short lifespan and severely limited diffusion distance of reactive oxygen species (ROS) generated by photosensitizer, as well as the penetration depth of visible light activation. Here, we develop a near-infrared (NIR) triggered nanophotosensitizer based on mitochondria targeted titanium dioxide-coated upconversion nanoparticles for PDT against cancer. When irradiated by NIR laser, the nanophotosensitizer could produce ROS in mitochondria, which induced the domino effect on ROS burst. The overproduced ROS accumulated in mitochondria, resulting in mitochondrial collapse and irreversible cell apoptosis. Confocal fluorescence imaging indicated that the mitochondrial targeting and real-time imaging of ROS burst could be achieved in living cells. The complete removal of tumor in vivo confirmed the excellent therapeutic effect of the nanophotosensitizer.
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Cites
Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455
Mitochondrial membrane permeabilization in cell death
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Tumor cell metabolism: cancer's Achilles' heel
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Chen, H., Gu, Z., An, H., Chen, C., Chen, J., Cui, R., Chen, S., Chen, W., Chen, X., Chen, X., et al. (2018) · Science China Chemistry · doi:10.1007/s11426-018-9397-5 · Cited by 409
Recent Advances in Subcellular Targeted Cancer Therapy Based on Functional Materials
Chen, W., Luo, G., & Zhang, X. (2019) · Advanced Materials · doi:10.1002/adma.201802725 · Cited by 373
Scintillating Nanoparticles as Energy Mediators for Enhanced Photodynamic Therapy
Kamkaew, A., Chen, F., Zhan, Y., Majewski, R. L., & Cai, W. (2016) · ACS Nano · doi:10.1021/acsnano.6b01401 · Cited by 355
Ma, Y., Li, X., Li, A., Yang, P., Zhang, C., & Tang, B. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201708005 · Cited by 355
Self-citationDefect‐Rich Adhesive Nanozymes as Efficient Antibiotics for Enhanced Bacterial Inhibition
Cao, F., Zhang, L., Wang, H., You, Y., Wang, Y., Gao, N., Ren, J., & Qu, X. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201908289 · Cited by 346
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Self-citationHu, P., Wu, T., Fan, W., Chen, L., Liu, Y., Ni, D., Bu, W., & Shi, J. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.06.035 · Cited by 266
Optical diagnostic imaging and therapy for thyroid cancer
Shao, C., Li, Z., Zhang, C., Zhang, W., He, R., Xu, J., & Cai, Y. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100441 · Cited by 68
Metadata
- Authors
- Yu, Z., Sun, Q., Pan, W., Li, N., & Tang, B.
- Venue
- ACS Nano
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-10-16
- Volume
- 9
- Issue
- 11
- Pages
- 11064-11074
- ISSN
- 1936-0851 (ISSN-L)
- 1936-086X
- OpenAlex
- W1798798079
- Cited by
- 299
- References
- 3
- FWCI
- 17.14
- Type
- journal article
- Language
- en
- Open access
- closed
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